In vivo evaluation of an anticancer drug delivery system based on heparinized mesoporous silica nanoparticles

RSC Advances ◽  
2015 ◽  
Vol 5 (50) ◽  
pp. 40103-40110 ◽  
Author(s):  
Qiang Wu ◽  
Ruifang Li ◽  
Chao Zhao ◽  
Jiejie Ren ◽  
Keyuan Du ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Drug Delivery System ◽  
Anticancer Drug ◽  
Delivery System ◽  
Mesoporous Silica Nanoparticles ◽  
In Vivo Evaluation ◽  
Anticancer Drug Delivery

MSNs-HP loaded with only a low amount of a drug (DOX0.3) achieve a similar antitumor efficacy to that of large doses of the drug (DOX2.0, 7-fold higher in dosage than DOX0.3).

In vitro and in vivo evaluation of sandwich-like mesoporous silica nanoflakes as promising anticancer drug delivery system

2016 ◽  
Vol 506 (1-2) ◽  
pp. 458-468 ◽  
Author(s):  
M. Peruzynska ◽  
S. Szelag ◽  
K. Trzeciak ◽  
M. Kurzawski ◽  
K. Cendrowski ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Drug Delivery System ◽  
Anticancer Drug ◽  
Delivery System ◽  
In Vivo Evaluation ◽  
Anticancer Drug Delivery

Enzyme responsive drug delivery system based on mesoporous silica nanoparticles for tumor therapy in vivo

2015 ◽  
Vol 26 (14) ◽  
pp. 145102 ◽  
Author(s):  
Yun Liu ◽  
Xingwei Ding ◽  
Jinghua Li ◽  
Zhong Luo ◽  
Yan Hu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Drug Delivery System ◽  
Delivery System ◽  
Mesoporous Silica Nanoparticles ◽  
Tumor Therapy

Wetting transition in nanochannels for biomimetic free-blocking on-demand drug transport

2018 ◽  
Vol 6 (39) ◽  
pp. 6269-6277 ◽  
Author(s):  
Yaya Cheng ◽  
Xiangyu Jiao ◽  
Liang Zhao ◽  
Yang Liu ◽  
Fang Wang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Drug Delivery System ◽  
Delivery System ◽  
Drug Transport ◽  
Mesoporous Silica Nanoparticles ◽  
Wetting Transition ◽  
On Demand ◽  
Inner Surface

Inspired by aquaporins in nature, herein, a biomimetic free-blocking on-demand drug delivery system is proposed, which is constructed by controlling the wettability of the inner surface of nanochannels on mesoporous silica nanoparticles (MSNs).

scholarly journals ADAM9-Responsive Mesoporous Silica Nanoparticles for Targeted Drug Delivery in Pancreatic Cancer

Cancers ◽  
2021 ◽  
Vol 13 (13) ◽  
pp. 3321
Author(s):  
Etienne J. Slapak ◽  
Lily Kong ◽  
Mouad el Mandili ◽  
Rienk Nieuwland ◽  
Alexander Kros ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Conditioned Medium ◽  
Drug Delivery System ◽  
Delivery System ◽  
Targeted Drug Delivery ◽  
Mesoporous Silica Nanoparticles ◽  
Pdac Cell ◽  
Targeted Drug

Pancreatic ductal adenocarcinoma (PDAC) has the worst survival rate of all cancers. This poor prognosis results from the lack of efficient systemic treatment regimens, demanding high-dose chemotherapy that causes severe side effects. To overcome dose-dependent toxicities, we explored the efficacy of targeted drug delivery using a protease-dependent drug-release system. To this end, we developed a PDAC-specific drug delivery system based on mesoporous silica nanoparticles (MSN) functionalized with an avidin–biotin gatekeeper system containing a protease linker that is specifically cleaved by tumor cells. Bioinformatic analysis identified ADAM9 as a PDAC-enriched protease, and PDAC cell-derived conditioned medium efficiently cleaved protease linkers containing ADAM9 substrates. Cleavage was PDAC specific as conditioned medium from leukocytes was unable to cleave the ADAM9 substrate. Protease linker-functionalized MSNs were efficiently capped with avidin, and cap removal was confirmed to occur in the presence of PDAC cell-derived ADAM9. Subsequent treatment of PDAC cells in vitro with paclitaxel-loaded MSNs indeed showed high cytotoxicity, whereas no cell death was observed in white blood cell-derived cell lines, confirming efficacy of the nanoparticle-mediated drug delivery system. Taken together, this research introduces a novel ADAM9-responsive, protease-dependent, drug delivery system for PDAC as a promising tool to reduce the cytotoxicity of systemic chemotherapy.

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