Characterization of stress degradation products of mirabegron using UPLC-QTOF-MS/MS and in silico toxicity predictions of its degradation products

Pradipbhai D. Kalariya; Mahesh Sharma; Prabha Garg; Jagadeshwar Reddy Thota; Srinivas Ragampeta; M. V. N. Kumar Talluri

doi:10.1039/c5ra01711d

Characterization of stress degradation products of mirabegron using UPLC-QTOF-MS/MS and in silico toxicity predictions of its degradation products

RSC Advances ◽

10.1039/c5ra01711d ◽

2015 ◽

Vol 5 (39) ◽

pp. 31024-31038 ◽

Cited By ~ 13

Author(s):

Pradipbhai D. Kalariya ◽

Mahesh Sharma ◽

Prabha Garg ◽

Jagadeshwar Reddy Thota ◽

Srinivas Ragampeta ◽

...

Keyword(s):

Overactive Bladder ◽

In Silico ◽

Adrenergic Receptor ◽

Receptor Agonist ◽

Degradation Products ◽

Stress Degradation ◽

In Silico Toxicity ◽

Adrenergic Receptor Agonist ◽

Bladder Disorder

Mirabegron is a novel beta-3 adrenergic receptor agonist in the treatment of overactive bladder disorder.

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Efficacy of the novel β3 adrenergic receptor agonist vibegron for the treatment of nocturia in patients with overactive bladder: A post hoc analysis of phase 3 study

European Urology Supplements ◽

10.1016/s1569-9056(19)31437-x ◽

2019 ◽

Vol 18 (1) ◽

pp. e1984-e1985

Author(s):

M. Yoshida ◽

M. Takeda ◽

M. Goto ◽

O. Yokoyama ◽

H. Kakizaki ◽

...

Keyword(s):

Overactive Bladder ◽

Adrenergic Receptor ◽

Receptor Agonist ◽

The Novel ◽

Phase 3 ◽

Post Hoc Analysis ◽

Post Hoc ◽

Adrenergic Receptor Agonist

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Study of degradation behavior of besifloxacin, characterization of its degradation products by LC–ESI–QTOF–MS and their in silico toxicity prediction

Biomedical Chromatography ◽

10.1002/bmc.4489 ◽

2019 ◽

Vol 33 (6) ◽

pp. e4489 ◽

Cited By ~ 1

Author(s):

Nishant Salunke ◽

Prashant S. Kharkar ◽

Nancy Pandita

Keyword(s):

In Silico ◽

Degradation Products ◽

Degradation Behavior ◽

Toxicity Prediction ◽

In Silico Toxicity

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Characterization of forced degradation products of canagliflozine by liquid chromatography/quadrupole time-of-flight tandem mass spectrometry and in silico toxicity predictions

Rapid Communications in Mass Spectrometry ◽

10.1002/rcm.8032 ◽

2018 ◽

Vol 32 (3) ◽

pp. 212-220 ◽

Cited By ~ 4

Author(s):

Shandilya Mahamuni Baira ◽

Pradipbhai D. Kalariya ◽

Rakesh Nimbalkar ◽

Prabha Garg ◽

R. Srinivas ◽

...

Keyword(s):

Mass Spectrometry ◽

Liquid Chromatography ◽

Tandem Mass Spectrometry ◽

In Silico ◽

Degradation Products ◽

Time Of Flight ◽

Forced Degradation ◽

Tandem Mass ◽

In Silico Toxicity

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Characterization of C6-10A glioma cells highly responsive to ?-adrenergic receptor agonist-induced NGF synthesis/secretion

Glia ◽

10.1002/glia.440120209 ◽

1994 ◽

Vol 12 (2) ◽

pp. 151-160 ◽

Cited By ~ 14

Author(s):

Hiroaki Fukumoto ◽

Mitsuru Kakihana ◽

Masahiro Suno

Keyword(s):

Adrenergic Receptor ◽

Receptor Agonist ◽

Glioma Cells ◽

Adrenergic Receptor Agonist

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Beta-3 adrenergic receptor agonist for adult with overactive bladder

Cochrane Database of Systematic Reviews ◽

10.1002/14651858.cd011593 ◽

2015 ◽

Author(s):

Michael Erlano Chua ◽

Marie Carmela M Lapitan ◽

Jan Michael A Silangcruz ◽

Saturnino Luna Jr. ◽

Marcelino Lopeztan Morales Jr.

Keyword(s):

Overactive Bladder ◽

Adrenergic Receptor ◽

Receptor Agonist ◽

Adrenergic Receptor Agonist

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FDG Uptake in Brown Adipose Tissue Activated by a β3-Adrenergic Receptor Agonist Prescribed for Overactive Bladder

Clinical Nuclear Medicine ◽

10.1097/rlu.0000000000003078 ◽

2020 ◽

Vol 45 (8) ◽

pp. 628-631

Author(s):

Chio Okuyama ◽

Ryutaro Kikuchi ◽

Takashi Ikeuchi

Keyword(s):

Adipose Tissue ◽

Overactive Bladder ◽

Brown Adipose Tissue ◽

Adrenergic Receptor ◽

Receptor Agonist ◽

Fdg Uptake ◽

Brown Adipose ◽

Adrenergic Receptor Agonist

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Characterization of forced degradation products and in silico toxicity prediction of Sofosbuvir: A novel HCV NS5B polymerase inhibitor

Journal of Pharmaceutical and Biomedical Analysis ◽

10.1016/j.jpba.2015.12.045 ◽

2016 ◽

Vol 120 ◽

pp. 352-363 ◽

Cited By ~ 22

Author(s):

Debasish Swain ◽

Gananadhamu Samanthula ◽

Shweta Bhagat ◽

P.V. Bharatam ◽

Venkatakrishna Akula ◽

...

Keyword(s):

In Silico ◽

Degradation Products ◽

Forced Degradation ◽

Toxicity Prediction ◽

Ns5b Polymerase Inhibitor ◽

In Silico Toxicity ◽

Polymerase Inhibitor ◽

Hcv Ns5b ◽

Ns5b Polymerase

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Mirabegron: β3-Adrenergic Receptor Agonist for the Treatment of Overactive Bladder

Annals of Pharmacotherapy ◽

10.1345/aph.1s054 ◽

2013 ◽

Vol 47 (7-8) ◽

pp. 1029-1038 ◽

Cited By ~ 8

Author(s):

Mary Barna Bridgeman ◽

Nicholas J Friia ◽

Christina Taft ◽

Milisha Shah

Keyword(s):

Overactive Bladder ◽

Adrenergic Receptor ◽

Receptor Agonist ◽

Adrenergic Receptor Agonist

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Characterization of Dark Liver Pigment Observed in Rats after Subchronic Dosing of the β3-Adrenergic Receptor Agonist LY368842

Chemical Research in Toxicology ◽

10.1021/tx0201016 ◽

2003 ◽

Vol 16 (7) ◽

pp. 912-919 ◽

Cited By ~ 1

Author(s):

Minxia M. He ◽

Robert J. Barbuch ◽

Trent L. Abraham ◽

Thomas J. Lindsay ◽

David A. Jackson ◽

...

Keyword(s):

Adrenergic Receptor ◽

Receptor Agonist ◽

Adrenergic Receptor Agonist

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Structure Characterization of Degradation Products of Drug Candidate HM30571 by UPLC‐QTOF‐MS and In Silico Toxicity Prediction

Bulletin of the Korean Chemical Society ◽

10.1002/bkcs.11913 ◽

2019 ◽

Vol 41 (1) ◽

pp. 92-95

Author(s):

Hyojeong Bang ◽

Wankyunn Whang ◽

Keukchan Bang ◽

Eunyoung Lee ◽

Eunyoung Kim ◽

...

Keyword(s):

In Silico ◽

Degradation Products ◽

Structure Characterization ◽

Drug Candidate ◽

Toxicity Prediction ◽

In Silico Toxicity

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