EDC/NHS activation mechanism of polymethacrylic acid: anhydride versus NHS-ester

RSC Advances ◽  
2015 ◽  
Vol 5 (86) ◽  
pp. 69939-69947 ◽  
Author(s):  
Qin Yan ◽  
Hong-Ning Zheng ◽  
Chuan Jiang ◽  
Kun Li ◽  
Shou-Jun Xiao
Keyword(s):  
Polymer Blends ◽  
Acid Anhydride ◽  
Activation Mechanism ◽  
Polymethacrylic Acid ◽  
Fragmentation Degree

Both stable intermediates of anhydride and NHS-ester were observed after EDC/NHS activation of PMAA, where NHS-ester waxes, while anhydride wanes complementarily with increasing fragmentation degree of PMAA blocks in PMAA-associated polymer blends.

Integration of Core-Edge Spectroscopy Methods for the Study of Polymers

1996 ◽  
Vol 54 ◽  
pp. 154-155
Author(s):  
E. G. Rightor
Keyword(s):  
Excited State ◽  
Polymer Blends ◽  
Gas Phase ◽  
Spatial Resolution ◽  
High Spatial Resolution ◽  
Electronic States ◽  
Core Electron ◽  
Bulk Solids ◽  
Development Application

Core edge spectroscopy methods are versatile tools for investigating a wide variety of materials. They can be used to probe the electronic states of materials in bulk solids, on surfaces, or in the gas phase. This family of methods involves promoting an inner shell (core) electron to an excited state and recording either the primary excitation or secondary decay of the excited state. The techniques are complimentary and have different strengths and limitations for studying challenging aspects of materials. The need to identify components in polymers or polymer blends at high spatial resolution has driven development, application, and integration of results from several of these methods.

A quantitative image analysis method for the determination of cocontinuity in polymer blends

1993 ◽  
Vol 51 ◽  
pp. 894-895
Author(s):  
William A. Heeschen
Keyword(s):  
Image Analysis ◽  
Polymer Blends ◽  
Quantitative Measurement ◽  
Morphological Evolution ◽  
Phase Ratio ◽  
Irregular Shapes ◽  
Quantitative Image ◽  
Discrete Domains ◽  
A Domains

Two new morphological measurements based on digital image analysis, CoContinuity and CoContinuity Balance, have been developed and implemented for quantitative measurement of morphology in polymer blends. The morphology of polymer blends varies with phase ratio, composition and processing. A typical morphological evolution for increasing phase ratio of polymer A to polymer B starts with discrete domains of A in a matrix of B (A/B < 1), moves through a cocontinuous distribution of A and B (A/B ≈ 1) and finishes with discrete domains of B in a matrix of A (A/B > 1). For low phase ratios, A is often seen as solid convex particles embedded in the continuous B phase. As the ratio increases, A domains begin to evolve into irregular shapes, though still recognizable as separate domains. Further increase in the phase ratio leads to A domains which extend into and surround the B phase while the B phase simultaneously extends into and surrounds the A phase.

Short Communication: Synthesis of Polymer-Embedded Metal Clusters by Thermolysis of Mercaptides—Polymer Blends

Polymer News ◽  
2005 ◽  
Vol 30 (9) ◽  
pp. 296-300
Author(s):  
F. Esposito ◽  
V. Casuscelli ◽  
M. V. Volpe ◽  
G. Carotenuto ◽  
L. Nicolais
Keyword(s):  
Polymer Blends ◽  
Short Communication ◽  
Metal Clusters ◽  
Communication Synthesis

Equilibrium emulsification of polymer blends by diblock copolymers

1990 ◽  
Vol 51 (2) ◽  
pp. 185-200 ◽  
Author(s):  
Zhen-Gang Wang ◽  
S.A. Safran
Keyword(s):  
Polymer Blends ◽  
Diblock Copolymers

Screening of interactions in polymer blends

1989 ◽  
Vol 50 (3) ◽  
pp. 245-253 ◽  
Author(s):  
M.G. Brereton ◽  
T.A. Vilgis
Keyword(s):  
Polymer Blends

Inhibition of NGLY1 inactivates the transcription factor Nrf1 and potentiates proteasome inhibitor cytotoxicity

2017 ◽  
Author(s):  
Carolyn Bertozzi ◽  
Fred Tomlin ◽  
Ulla Gerling-Driessen ◽  
Yi-Chang Liu ◽  
Ryan Flynn ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Small Molecule ◽  
Proteasome Inhibitor ◽  
Activation Mechanism ◽  
Cancer Drugs ◽  
Small Molecule Library ◽  
Library Screen ◽  
In Cells

We discovered that the proteostasis modulating transcription factor Nrf1 requires cytosolic de-N-glycosylation by the N-glycanase NGly1 as part of its activation mechanism. Through a covalent small molecule library screen, we discovered an inhibitor of NGly1 that blocks Nrf1 activation in cells and potentiates the activity of proteasome inhibitor cancer drugs. The requirement of NGly1 for Nrf1 activity likely underlies several pathologies associated with a rare hereditary deficiency in NGly1.

Electret-thermal Analysis of Polymer Blends

2003 ◽  
Vol 18 (2) ◽  
pp. 151-155 ◽  
Author(s):  
L. S. Pinchuk ◽  
V. A. Goldade ◽  
A. G. Kravtsov ◽  
S. V. Zotov ◽  
B. Jurkowski ◽  
...  
Keyword(s):  
Thermal Analysis ◽  
Polymer Blends
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