The recent developments and applications of the traceless-Staudinger reaction in chemical biology study

RSC Advances ◽  
2015 ◽  
Vol 5 (130) ◽  
pp. 107192-107199 ◽  
Author(s):  
Zhi-Peng A. Wang ◽  
Chang-Lin Tian ◽  
Ji-Shen Zheng
Keyword(s):  
Chemical Biology ◽  
Life Science ◽  
Staudinger Reaction ◽  
Biological Applications ◽  
Bioorthogonal Reactions ◽  
Recent Developments

Bioorthogonal reactions are one of the most important topics in chemical biology. Traceless-Staudinger reaction/ligation has been investigated and widely applied in life science. Herein, the current developments, mechanism studies, and biological applications are summarized.

Reductive Amination/Alkylation Reactions: The Recent Developments, Progresses, and Applications in Protein Chemical Biology Studies

2018 ◽  
Vol 15 (6) ◽  
pp. 755-761 ◽  
Author(s):  
Zhipeng A. Wang ◽  
Yan-Yu Liang ◽  
Ji-Shen Zheng
Keyword(s):  
Chemical Biology ◽  
Reductive Amination ◽  
High Efficiency ◽  
Protein Complexes ◽  
Protein Chemistry ◽  
Bioorthogonal Reactions ◽  
Chemistry Research ◽  
Amination Reaction ◽  
Recent Developments ◽  
Alkylation Reactions

The chemical modifications of proteins or protein complexes have been a challenging but fruitful task in the post-genomic era. Bioorthogonal reactions play an important role for the purpose of selective functionalization, localization, and labeling of proteins with natural or non-natural structures. Among these reactions, reductive amination stands out as one of the typical bioorthogonal reactions with high efficiency, good biocompatibility, and versatile applications. However, not many specific reviews exist to discuss the mechanism, kinetics, and their applications in a detailed manner. In this manuscript, we aim to summarize some current developments and mechanistic studies of reductive amination reaction and its applications. We hope reductive amination reaction can contribute to a wider scope of protein chemistry research en route in the chemical biology frontier as one of the well-known bioorthogonal reactions.

scholarly journals Visible Light Photochemical Reactions for Nucleic Acid-Based Technologies

Molecules ◽  
2021 ◽  
Vol 26 (3) ◽  
pp. 556
Author(s):  
Bonwoo Koo ◽  
Haneul Yoo ◽  
Ho Jeong Choi ◽  
Min Kim ◽  
Cheoljae Kim ◽  
...  
Keyword(s):  
Nucleic Acid ◽  
Nucleic Acids ◽  
Visible Light ◽  
Chemical Reactions ◽  
Chemical Biology ◽  
Photochemical Reactions ◽  
Reaction Conditions ◽  
Promising Tool ◽  
Recent Developments ◽  
Visible Light Driven

The expanding scope of chemical reactions applied to nucleic acids has diversified the design of nucleic acid-based technologies that are essential to medicinal chemistry and chemical biology. Among chemical reactions, visible light photochemical reaction is considered a promising tool that can be used for the manipulations of nucleic acids owing to its advantages, such as mild reaction conditions and ease of the reaction process. Of late, inspired by the development of visible light-absorbing molecules and photocatalysts, visible light-driven photochemical reactions have been used to conduct various molecular manipulations, such as the cleavage or ligation of nucleic acids and other molecules as well as the synthesis of functional molecules. In this review, we describe the recent developments (from 2010) in visible light photochemical reactions involving nucleic acids and their applications in the design of nucleic acid-based technologies including DNA photocleaving, DNA photoligation, nucleic acid sensors, the release of functional molecules, and DNA-encoded libraries.

scholarly journals Recent developments of ion sources for life-science studies at the Heavy Ion Medical Accelerator in Chiba (invited)

2016 ◽  
Vol 87 (2) ◽  
pp. 02C107 ◽  
Author(s):  
A. Kitagawa ◽  
A. G. Drentje ◽  
T. Fujita ◽  
M. Muramatsu ◽  
K. Fukushima ◽  
...  
Keyword(s):  
Life Science ◽  
Science Studies ◽  
Heavy Ion ◽  
Ion Sources ◽  
Recent Developments

Bottom-Up Synthetic Biology: Engineering in a Tinkerer’s World

Science ◽  
2011 ◽  
Vol 333 (6047) ◽  
pp. 1252-1254 ◽  
Author(s):  
Petra Schwille
Keyword(s):  
Synthetic Biology ◽  
Life Science ◽  
Biological Systems ◽  
Living Systems ◽  
Design Features ◽  
Literal Interpretation ◽  
Bottom Up ◽  
Systematic Construction ◽  
Science Discipline ◽  
Recent Developments

How synthetic can “synthetic biology” be? A literal interpretation of the name of this new life science discipline invokes expectations of the systematic construction of biological systems with cells being built module by module—from the bottom up. But can this possibly be achieved, taking into account the enormous complexity and redundancy of living systems, which distinguish them quite remarkably from design features that characterize human inventions? There are several recent developments in biology, in tight conjunction with quantitative disciplines, that may bring this literal perspective into the realm of the possible. However, such bottom-up engineering requires tools that were originally designed by nature’s greatest tinkerer: evolution.

The Life Science Toolbox Provided by Chemical Biology

2019 ◽  
Vol 59 (1-2) ◽  
pp. 100-105
Author(s):  
Carsten Schultz
Keyword(s):  
Chemical Biology ◽  
Life Science

scholarly journals Adaptive coevolutionary networks: a review

2007 ◽  
Vol 5 (20) ◽  
pp. 259-271 ◽  
Author(s):  
Thilo Gross ◽  
Bernd Blasius
Keyword(s):  
Game Theory ◽  
Complex Dynamics ◽  
Self Organization ◽  
Adaptive Networks ◽  
Biological Applications ◽  
Network Nodes ◽  
Topological Evolution ◽  
Recent Developments

Adaptive networks appear in many biological applications. They combine topological evolution of the network with dynamics in the network nodes. Recently, the dynamics of adaptive networks has been investigated in a number of parallel studies from different fields, ranging from genomics to game theory. Here we review these recent developments and show that they can be viewed from a unique angle. We demonstrate that all these studies are characterized by common themes, most prominently: complex dynamics and robust topological self-organization based on simple local rules.

Recent Developments in the Chemistry and in the Biological Applications of Amidoximes

2008 ◽  
Vol 14 (10) ◽  
pp. 1001-1047 ◽  
Author(s):  
K. Fylaktakidou ◽  
D. Hadjipavlou-Litina ◽  
K. Litinas ◽  
E. Varella ◽  
D. Nicolaides
Keyword(s):  
Biological Applications ◽  
Recent Developments
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