Reductive Amination/Alkylation Reactions: The Recent Developments, Progresses, and Applications in Protein Chemical Biology Studies

2018 ◽  
Vol 15 (6) ◽  
pp. 755-761 ◽  
Author(s):  
Zhipeng A. Wang ◽  
Yan-Yu Liang ◽  
Ji-Shen Zheng
Keyword(s):  
Chemical Biology ◽  
Reductive Amination ◽  
High Efficiency ◽  
Protein Complexes ◽  
Protein Chemistry ◽  
Bioorthogonal Reactions ◽  
Chemistry Research ◽  
Amination Reaction ◽  
Recent Developments ◽  
Alkylation Reactions

The chemical modifications of proteins or protein complexes have been a challenging but fruitful task in the post-genomic era. Bioorthogonal reactions play an important role for the purpose of selective functionalization, localization, and labeling of proteins with natural or non-natural structures. Among these reactions, reductive amination stands out as one of the typical bioorthogonal reactions with high efficiency, good biocompatibility, and versatile applications. However, not many specific reviews exist to discuss the mechanism, kinetics, and their applications in a detailed manner. In this manuscript, we aim to summarize some current developments and mechanistic studies of reductive amination reaction and its applications. We hope reductive amination reaction can contribute to a wider scope of protein chemistry research en route in the chemical biology frontier as one of the well-known bioorthogonal reactions.

The recent developments and applications of the traceless-Staudinger reaction in chemical biology study

RSC Advances ◽  
2015 ◽  
Vol 5 (130) ◽  
pp. 107192-107199 ◽  
Author(s):  
Zhi-Peng A. Wang ◽  
Chang-Lin Tian ◽  
Ji-Shen Zheng
Keyword(s):  
Chemical Biology ◽  
Life Science ◽  
Staudinger Reaction ◽  
Biological Applications ◽  
Bioorthogonal Reactions ◽  
Recent Developments

Bioorthogonal reactions are one of the most important topics in chemical biology. Traceless-Staudinger reaction/ligation has been investigated and widely applied in life science. Herein, the current developments, mechanism studies, and biological applications are summarized.

Selective Functionalization at N2-Position of Guanine in Oligonucleotides via Reductive Amination

2020 ◽  
Author(s):  
Bapurao Bhoge ◽  
Ishu Saraogi
Keyword(s):  
Organic Chemistry ◽  
Chemical Biology ◽  
Reductive Amination ◽  
The Other ◽  
Dna Oligomers ◽  
Site Specific ◽  
Wide Applicability ◽  
Dna Oligonucleotides ◽  
Selective Functionalization

Chemo- and site-specific modifications in oligonucleotides have wide applicability as mechanistic probes in chemical biology. Here we have employed a classical reaction in organic chemistry, reductive amination, to selectively functionalize the N<sup>2</sup>-amine of guanine/2’-deoxyguanine monophosphate. This method specifically modifies guanine in several tested DNA oligonucleotides, while leaving the other bases unaffected. Using this approach, we have successfully incorporated desired handles chemoselectively into DNA oligomers.

Mass Spectrometry for Proteomics and Recent Developments in ESI, MALDI and other Ionization Methodologies

2019 ◽  
Vol 16 (4) ◽  
pp. 267-276
Author(s):  
Qurat ul Ain Farooq ◽  
Noor ul Haq ◽  
Abdul Aziz ◽  
Sara Aimen ◽  
Muhammad Inam ul Haq
Keyword(s):  
Mass Spectrometry ◽  
Electrospray Ionization ◽  
New Technologies ◽  
Protein Complexes ◽  
Imaging Techniques ◽  
Desorption Electrospray Ionization ◽  
High Throughput Analysis ◽  
Enhanced Sensitivity ◽  
Recent Developments ◽  
The Way

Background: Mass spectrometry is a tool used in analytical chemistry to identify components in a chemical compound and it is of tremendous importance in the field of biology for high throughput analysis of biomolecules, among which protein is of great interest. Objective: Advancement in proteomics based on mass spectrometry has led the way to quantify multiple protein complexes, and proteins interactions with DNA/RNA or other chemical compounds which is a breakthrough in the field of bioinformatics. Methods: Many new technologies have been introduced in electrospray ionization (ESI) and Matrixassisted Laser Desorption/Ionization (MALDI) techniques which have enhanced sensitivity, resolution and many other key features for the characterization of proteins. Results: The advent of ambient mass spectrometry and its different versions like Desorption Electrospray Ionization (DESI), DART and ELDI has brought a huge revolution in proteomics research. Different imaging techniques are also introduced in MS to map proteins and other significant biomolecules. These drastic developments have paved the way to analyze large proteins of >200kDa easily. Conclusion: Here, we discuss the recent advancement in mass spectrometry, which is of great importance and it could lead us to further deep analysis of the molecules from different perspectives and further advancement in these techniques will enable us to find better ways for prediction of molecules and their behavioral properties.

Recent Developments in Azole Compounds as Antitubercular Agent

2019 ◽  
Vol 16 (3) ◽  
pp. 290-306
Author(s):  
Rina Das ◽  
Gyati S. Asthana ◽  
Krishan A. Suri ◽  
Dinesh Mehta ◽  
Abhay Asthana
Keyword(s):  
Therapeutic Agent ◽  
Current Problem ◽  
Noncovalent Interactions ◽  
Drug Resistant ◽  
Antitubercular Drugs ◽  
Chemistry Research ◽  
Improper Use ◽  
Recent Developments ◽  
Important Direction ◽  
Tuberculosis Therapy

Tuberculosis (TB) is a global health disaster and is a wide-reaching hitch. The improper use of antibiotics in chemotherapy of TB patients led to the current problem of tuberculosis therapy which gives rise to Multi-Drug Resistant (MDR) strains. Nitrogen heterocycles including azole compounds are an important class of therapeutic agent with electron-rich property. Azole-based derivatives easily bind with the enzymes and receptors in organisms through noncovalent interactions, thereby possessing various applications in medicinal chemistry. Research on azoles derivatives have been expansively carried out and have become one of the extremely active area in recent years and the progress is quite rapid. A genuine attempt to review chemistry of azoles and to describe various azole-based compounds synthesized in the last two decades having promising antitubercular potential is described in the present article. It is hopeful that azole compounds may continue to serve as an important direction for the exploitation of azole-based antitubercular drugs with better curative effect, lower toxicity, less side effects, especially fewer resistances and so on.

scholarly journals Recent Developments on Five-Component Reactions

Molecules ◽  
2021 ◽  
Vol 26 (7) ◽  
pp. 1986
Author(s):  
Xiaoming Ma ◽  
Sanjun Zhi ◽  
Wei Zhang
Keyword(s):  
Multicomponent Reactions ◽  
High Efficiency ◽  
Review Article ◽  
Reaction Centers ◽  
Synthetic Approach ◽  
Recent Developments

Multicomponent reactions (MCRs) have inherent advantages in pot, atom, and step economy (PASE). This important green synthetic approach has gained increasing attention due to high efficiency, minimal waste, saving resources, and straightforward procedures. Presented in this review article are the recent development on 5-compoment reactions (5CRs) of the following six types: (I) five different molecules A + B + C + D + E; pseudo-5CRs including (II) 2A + B + C + D, (III) 2A + 2B + C, (IV) 3A + B + C, (V) 3A + 2B, and (VI) 4A + B. 5CRs with more than five-reaction centers are also included.

scholarly journals Visible Light Photochemical Reactions for Nucleic Acid-Based Technologies

Molecules ◽  
2021 ◽  
Vol 26 (3) ◽  
pp. 556
Author(s):  
Bonwoo Koo ◽  
Haneul Yoo ◽  
Ho Jeong Choi ◽  
Min Kim ◽  
Cheoljae Kim ◽  
...  
Keyword(s):  
Nucleic Acid ◽  
Nucleic Acids ◽  
Visible Light ◽  
Chemical Reactions ◽  
Chemical Biology ◽  
Photochemical Reactions ◽  
Reaction Conditions ◽  
Promising Tool ◽  
Recent Developments ◽  
Visible Light Driven

The expanding scope of chemical reactions applied to nucleic acids has diversified the design of nucleic acid-based technologies that are essential to medicinal chemistry and chemical biology. Among chemical reactions, visible light photochemical reaction is considered a promising tool that can be used for the manipulations of nucleic acids owing to its advantages, such as mild reaction conditions and ease of the reaction process. Of late, inspired by the development of visible light-absorbing molecules and photocatalysts, visible light-driven photochemical reactions have been used to conduct various molecular manipulations, such as the cleavage or ligation of nucleic acids and other molecules as well as the synthesis of functional molecules. In this review, we describe the recent developments (from 2010) in visible light photochemical reactions involving nucleic acids and their applications in the design of nucleic acid-based technologies including DNA photocleaving, DNA photoligation, nucleic acid sensors, the release of functional molecules, and DNA-encoded libraries.

Collaborative Research Funding

2014 ◽  
Vol 36 (4) ◽  
Author(s):  
Markus Behnke ◽  
Laura McConnell ◽  
Chris Ober
Keyword(s):  
International Collaboration ◽  
Research Funding ◽  
International Committee ◽  
Research Projects ◽  
Scientific Success ◽  
Funding Sources ◽  
Chemistry Research ◽  
National Organizations ◽  
Recent Developments ◽  
History Of

Within a changing research world, international collaboration has become even more important in achieving scientific success. Given the increased need and desire for multinational research, the actors are forced to identify appropriate funding sources. Whereas, science knows no international boundaries, support for scientific research, including in chemical sciences, is mostly provided by the national funding organizations. This is particularly true for the chemical sciences, where most research projects are relatively small in size and with respect to the number of involved PIs. Traditionally, national organizations are reluctant to provide funds to non-domestic researchers, and in practice, funding truly international research projects can be a real challenge for a variety of technical and bureaucratic reasons. In an effort to change this, an international Committee on Chemistry Research Funding (CCRF)—backed by several leading funding organizations—was established by IUPAC in December 2007 to promote increased international collaboration and networking in the global chemistry community. The following report gives a short overview on the history of IUPAC’s involvement in service for chemistry research funding and on the most recent developments.

scholarly journals Computational investigation of the control of the thermodynamics and microkinetics of the reductive amination reaction by solvent coordination and a co-catalyst

RSC Advances ◽  
2018 ◽  
Vol 8 (64) ◽  
pp. 36662-36674 ◽  
Author(s):  
Esra Boz ◽  
Nurcan Ş. Tüzün ◽  
Matthias Stein
Keyword(s):  
Tertiary Amine ◽  
Reductive Amination ◽  
Computational Investigation ◽  
Reaction Parameters ◽  
Co Catalyst ◽  
Amination Reaction ◽  
Green Production

Green production of tertiary amine from sustainable sources can be controlled by appropriate choice of reaction parameters identified by computational means.

scholarly journals Modelling of sensored speed control of BLDC motor using MATLAB/SIMULINK

2019 ◽  
Vol 9 (5) ◽  
pp. 3333
Author(s):  
Basim Alsayid ◽  
Wael A. Salah ◽  
Yazeed Alawneh
Keyword(s):  
High Efficiency ◽  
Speed Control ◽  
Control Algorithms ◽  
Bldc Motor ◽  
Motor Speed ◽  
Operating Life ◽  
Matlab Simulink ◽  
Sensor Control ◽  
Recent Developments ◽  
High Dynamic

<span style="font-size: 9pt; font-family: 'Times New Roman','serif'; mso-bidi-font-style: italic; mso-fareast-font-family: 'Times New Roman'; mso-ansi-language: EN-US; mso-fareast-language: EN-US; mso-bidi-language: AR-SA;">Recent developments in the field of magnetic materials and power electronics, along with the availability of cheap powerful processors, have increased the adoption of brushless direct current (BLDC) motors for various applications, such as in home appliances as well as in automotive, aerospace, and medical industries. The wide adoption of this motor is due to its many advantages over other types of motors, such as high efficiency, high dynamic response, long operating life, relatively quiet operation, and higher speed ranges. This paper presents a simulation of digital sensor control of permanent magnet BLDC motor speed using the MATLAB/SIMULINK environment. A closed loop speed control was developed, and different tests were conducted to evaluate the validity of the control algorithms. Results confirm the satisfactory operation of the proposed control algorithms.</span>

Sign in / Sign up

Export Citation Format

Share Document