Synthesis of metapristone through an efficient N-demethylation of mifepristone

RSC Advances ◽  
2016 ◽  
Vol 6 (9) ◽  
pp. 7195-7197 ◽  
Author(s):  
Jianlei Wu ◽  
Xuemei Yu ◽  
Jian Liu ◽  
Yuqin Lin ◽  
Yu Gao ◽  
...  
Keyword(s):  
Excellent Yield ◽  
Efficient Condition

An improved and efficient condition of N-demethylation of mifepristone in an excellent yield is described.

Synthesis, structural characterization, and bonding analysis of two-coordinate copper(I) and silver(I) complexes of the pyrrole-based bis(phosphinimine): new metal-pyrrole ring π-interactions

2021 ◽  
Author(s):  
Ganesan Mani ◽  
Vikesh Kumar Jha ◽  
Sanghamitra Das ◽  
VASUDEVAN SUBRAMANIYAN ◽  
Tapas Guchhait ◽  
...  
Keyword(s):  
Structural Characterization ◽  
Pyrrole Ring ◽  
Bonding Analysis ◽  
Π Interactions ◽  
Excellent Yield

The reaction between 2,5-bis(diphenylphosphinomethyl)pyrrole and Me3SiN3 gave the new pyrrole-based bis(phosphinimine) L1H in an excellent yield. L1H reacts with [CuCl(COD)]2, AgBF4, or AgOTf to give the corresponding two-coordinate mononuclear ionic...

scholarly journals (1R,4S,5S)-5-((3-Hydroxypropyl)amino)-4-((1-Methyl-1H-tetrazol-5-yl)thio)Cyclopent-2-en-1-ol

Molbank ◽  
10.3390/m1199 ◽  
2021 ◽  
Vol 2021 (2) ◽  
pp. M1199
Author(s):  
Milene A. G. Fortunato ◽  
Filipa Siopa ◽  
Carlos A. M. Afonso
Keyword(s):  
Spectral Data ◽  
13C Nmr ◽  
Ring Opening ◽  
Environmentally Friendly ◽  
Mass Spectral Data ◽  
Mass Spectral ◽  
Excellent Yield ◽  
Ring Opening Reaction ◽  
Nucleophilic Ring Opening

Using environmentally friendly conditions, the nucleophilic ring-opening reaction of 6-azabicyclo[3.1.0]hex-3-en-2-ol with 1-methyl-1H-tetrazole-5-thiol provided a novel thiol-incorporated aminocyclopentitol, (1R,4S,5S)-5-((3-hydroxypropyl)amino)-4-((1-methyl-1H-tetrazol-5-yl)thio)cyclopent-2-en-1-ol, in excellent yield (95%). The newly synthesized compound was analyzed and characterized via 1H, 13C-NMR, HSQC, and mass spectral data.

Synthesis of 1,1-diacetates from Aromatic Aldehydes using Cerium(IV) Sulfate Tetrahydrate as Catalyst under Solvent-free Conditions

2005 ◽  
Vol 2005 (3) ◽  
pp. 171-172 ◽  
Author(s):  
Min Zhang ◽  
Yi-Qun Li
Keyword(s):  
Room Temperature ◽  
Aromatic Aldehydes ◽  
Solvent Free ◽  
Excellent Yield ◽  
Solvent Free Conditions

Aromatic aldehydes can be converted into the corresponding 1,1-diacetates rapidly in the presence of catalytic amounts of Ce(SO4)2·4H2O at room temperature in excellent yield under solvent-free conditions. The catalyst can easily be recovered and reused at least 4 times.

The Training of Aircraft Apprentices

1927 ◽  
Vol 31 (196) ◽  
pp. 345-345
Author(s):  
C. D. Breese
Keyword(s):  
General Education ◽  
Present System ◽  
Efficient Condition ◽  
Highly Skilled

Before asking the Lecturer to reply, I should like to ask him one or two questions.What percentage of the mechanics now in the R.A.F. have been trained at Halton?It would appear to me that two classes of mechanics are wanted. Firstly, those who are competent to do what might be termed running repairs; and secondly, those who are highly skilled and capable of undertaking major repairs generally. The scheme in force at present seems to fill neither of these requirements. General education is of course needed, but far too much attention would seem to be paid to this subject. The aim is surely to train out personnel who will be able to keep the equipment of the R.A.F. in efficient condition and this aim should not be lost sight of. It is presumed that but a small number of those trained will be able to get Commissions, and this being so, the present system would seem liable to engender dissatisfaction.

scholarly journals Mild and efficient cyanuric chloride catalyzed Pictet–Spengler reaction

2013 ◽  
Vol 9 ◽  
pp. 1235-1242 ◽  
Author(s):  
Ashish Sharma ◽  
Mrityunjay Singh ◽  
Nitya Nand Rai ◽  
Devesh Sawant
Keyword(s):  
Catalytic Amount ◽  
Nitrogen Atmosphere ◽  
Cyanuric Chloride ◽  
Distinct Advantage ◽  
First Report ◽  
Excellent Yield

A practical, mild and efficient protocol for the Pictet–Spengler reaction catalyzed by cyanuric chloride (trichloro-1,3,5-triazine, TCT) is described. The 6-endo cyclization of tryptophan/tryptamine and modified Pictet–Spengler substrates with both electron-withdrawing and electron-donating aldehydes was carried out by using a catalytic amount of TCT (10 mol %) in DMSO under a nitrogen atmosphere. TCT catalyzed the Pictet–Spengler reaction involving electron-donating aldehydes in excellent yield. Thus, it has a distinct advantage over the existing methodologies where electron-donating aldehydes failed to undergo 6-endo cyclization. Our methodology provided broad substrate scope and diversity. This is indeed the first report of the use of TCT as a catalyst for the Pictet–Spengler reaction.

Palladium chloride catalyzed photochemical Heck reaction

2013 ◽  
Vol 91 (5) ◽  
pp. 348-351 ◽  
Author(s):  
Suresh B. Waghmode ◽  
Sudhir S. Arbuj ◽  
Bina N. Wani ◽  
C.S. Gopinath
Keyword(s):  
Visible Light ◽  
Heck Reaction ◽  
Palladium Nanoparticles ◽  
Bond Formation ◽  
Aryl Halides ◽  
Palladium Chloride ◽  
Carbon Bond ◽  
Excellent Yield ◽  
Carbon Carbon Bond ◽  
Uv Visible

PdCl2 catalyzed carbon–carbon bond formation (Heck reaction) between substituted aryl halides and olefins was carried out without a ligand, under irradiation with UV–visible light. The results demonstrated that UV–visible light accelerated the rate of the reaction, leading to an excellent yield of corresponding products. The recovered palladium nanoparticles could be thermally recycled several times. PdCl2 gave excellent conversion up to the fifth addition of substrate.

Sulfated polyborate: a new and eco-friendly catalyst for one-pot multi-component synthesis of 3,4-dihydropyrimidin-2(1H)-ones/thiones via Biginelli reaction

2016 ◽  
Vol 40 (12) ◽  
pp. 10412-10417 ◽  
Author(s):  
Chetan K. Khatri ◽  
Deelip S. Rekunge ◽  
Ganesh U. Chaturbhuj
Keyword(s):  
Biginelli Reaction ◽  
Solvent Free ◽  
Synthetic Methodology ◽  
One Pot ◽  
Free Condition ◽  
Sulfated Polyborate ◽  
Highly Efficient ◽  
Excellent Yield ◽  
Solvent Free Condition

A highly efficient and improved synthetic methodology for the preparation of 3,4-dihydropyrimidin-2(1H)-one derivatives in good to excellent yield via Biginelli reaction of β-ketoesters/β-diketone, urea/thiourea and various aldehydes using new, efficient and recyclable sulfated polyborate catalyst under the solvent-free condition is reported.

Synthesis of polyamides using palladium-on-carbon (Pd/C) as a heterogeneous, reusable and ligand-free catalytic system

RSC Advances ◽  
2015 ◽  
Vol 5 (114) ◽  
pp. 93773-93778 ◽  
Author(s):  
Anilkumar Satapathy ◽  
Sandip T. Gadge ◽  
Takehiko Sasaki ◽  
Bhalchandra M. Bhanage
Keyword(s):  
Catalytic System ◽  
Basic Problem ◽  
Catalyst Recovery ◽  
Excellent Yield ◽  
System P ◽  
Ligand Free ◽  
Palladium On Carbon

Polyamide has been synthesized by using Pd/C as a heterogeneous, phosphine-free and reusable catalytic system. The catalyst solves the basic problem of catalyst recovery and furnishes good to excellent yield of polyamides.

Ruthenium and Iron Carbonyl Clusters Catalyzed Reduction of N,N-dimethylbenzamide and N,N-diethyl-(3-methyl)benzamide

2011 ◽  
Vol 396-398 ◽  
pp. 2485-2488
Author(s):  
Bao Hua Zhu ◽  
Guo Hua Xu ◽  
Zhi Wei Xia
Keyword(s):  
Ir Spectroscopy ◽  
Elemental Analysis ◽  
Iron Carbonyl ◽  
Carbonyl Cluster ◽  
Carbonyl Clusters ◽  
Excellent Yield ◽  
Ruthenium Carbonyl ◽  
Vis Spectroscopy

One new Ruthenium and one known Iron bimetallic carbonyl clusters containing triphos (1,1,1-tris(diphenylphosphinomethyl)ethane) ligand have been prepared as catalyst to study the reduction of amide to amine. All clusters were characterized by elemental analysis, 1HNMR, 31PNMR and IR spectroscopy. The reduction of N,N-dimethylbenzamide and N,N-diethyl-(3-methyl) benzamide catalyzed by Ru and Fe carbonyl clusters were investigated at 100 ~ 110 °C for 24 ~ 28h, polymethylhydrogensiloxane (PMHS) as reduction agent. The products were analysized using GC-MS, IR and UV-vis spectroscopy and an excellent yield (97%) of N,N-diethyl- (3-methyl)benzamine was obtained when using 3 mol% of bimetallic ruthenium carbonyl cluster as catalyst. The data of IR and UV-vis show that the frameworks of clusters are not changed remarkably during the reaction.

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