Synthesis of pH-responsive hydrogel thin films grafted on PCL substrates for protein delivery

2015 ◽  
Vol 3 (39) ◽  
pp. 7673-7681 ◽  
Author(s):  
Lihua Zhang ◽  
Yuhong Ma ◽  
Changwen Zhao ◽  
Xing Zhu ◽  
Ruichao Chen ◽  
...  
Keyword(s):  
Thin Films ◽  
Drug Delivery ◽  
Visible Light ◽  
Protein Delivery ◽  
Graft Polymerization ◽  
Ph Sensitive ◽  
Ph Responsive ◽  
Polymer Substrates ◽  
Polymerization Method ◽  
Ph Sensitive Hydrogel

A new visible light induced graft polymerization method was utilized to prepare pH-sensitive hydrogel layers covalently attached to polymer substrates for drug delivery.

New insights into an innovative Auricularia auricular polysaccharide pH-sensitive hydrogel for controlled protein drug delivery

RSC Advances ◽  
2016 ◽  
Vol 6 (64) ◽  
pp. 59794-59799 ◽  
Author(s):  
Yibin Yu ◽  
Hao Pan ◽  
Yingying Wang ◽  
Wei Xiong ◽  
Qiantao Zhang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Protein Delivery ◽  
Ph Sensitive ◽  
Protein Drug ◽  
Protein Drug Delivery ◽  
First Time ◽  
Polysaccharide Hydrogel ◽  
Ph Sensitive Hydrogel

An innovative pH-sensitive Auricularia auricular polysaccharide hydrogel was developed for effective controlled protein delivery for the first time.

Preparation and characterization of pH-sensitive hydrogel for drug delivery system

RSC Advances ◽  
2012 ◽  
Vol 2 (20) ◽  
pp. 7772 ◽  
Author(s):  
Ke Wang ◽  
Qiang Fu ◽  
Xi Chen ◽  
Yang Gao ◽  
Kai Dong
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Ph Sensitive ◽  
Ph Sensitive Hydrogel

A novel pH-sensitive hydrogel composed of N,O-carboxymethyl chitosan and alginate cross-linked by genipin for protein drug delivery

2004 ◽  
Vol 96 (2) ◽  
pp. 285-300 ◽  
Author(s):  
Sung-Ching Chen ◽  
Yung-Chih Wu ◽  
Fwu-Long Mi ◽  
Yu-Hsin Lin ◽  
Lin-Chien Yu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Carboxymethyl Chitosan ◽  
Ph Sensitive ◽  
Protein Drug ◽  
Protein Drug Delivery ◽  
Ph Sensitive Hydrogel

pH-sensitive hydrogel based on carboxymethyl chitosan/sodium alginate and its application for drug delivery

2018 ◽  
Vol 136 (1) ◽  
pp. 46911 ◽  
Author(s):  
Cong-Xia Xie ◽  
Ting-Cui Tian ◽  
Shi-Tao Yu ◽  
Lu Li
Keyword(s):  
Drug Delivery ◽  
Sodium Alginate ◽  
Carboxymethyl Chitosan ◽  
Ph Sensitive ◽  
Ph Sensitive Hydrogel

Glutathione functionalized mesoporous organosilica conjugate for drug delivery

RSC Advances ◽  
2016 ◽  
Vol 6 (61) ◽  
pp. 56287-56293 ◽  
Author(s):  
Lin-Lin Hu ◽  
Dan-Dan Zhang ◽  
Yang Zhang ◽  
Yang Shu ◽  
Xu-Wei Chen ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Polyacrylic Acid ◽  
Ph Sensitive ◽  
Ph Responsive ◽  
Mesoporous Organosilica

We developed a novel pH-responsive drug delivery system based on permeation-enhancing glutathione (GSH) and pH sensitive polyacrylic acid (PAA) grafted mesoporous organosilica nanocarriers (MONs).

Chinese quince seed gum and poly ( N,N -diethylacryl amide-co-methacrylic acid) based pH-sensitive hydrogel for use in drug delivery

2018 ◽  
Vol 185 ◽  
pp. 96-104 ◽  
Author(s):  
Ai-Jun Xie ◽  
Hui-Shuang Yin ◽  
Hua-Min Liu ◽  
Chun-Yan Zhu ◽  
Ya-Jie Yang
Keyword(s):  
Drug Delivery ◽  
Methacrylic Acid ◽  
Ph Sensitive ◽  
Chinese Quince ◽  
Seed Gum ◽  
Ph Sensitive Hydrogel

A pH-responsive drug delivery system with an aggregation-induced emission feature for cell imaging and intracellular drug delivery

2015 ◽  
Vol 6 (26) ◽  
pp. 4715-4718 ◽  
Author(s):  
Haibo Wang ◽  
Gongyan Liu ◽  
Haiqi Gao ◽  
Yunbing Wang
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Cell Imaging ◽  
Emission Feature ◽  
Ph Sensitive ◽  
Ph Responsive ◽  
Therapeutic Treatment ◽  
Aggregation Induced Emission ◽  
Intracellular Drug Delivery

A pH-sensitive fluorescent vehicle based on aggregation-induced emission (AIE) has been developed as a drug delivery system for simultaneous cell imaging and therapeutic treatment.

scholarly journals Advances in the Design of pH-Sensitive Cubosome Liquid Crystalline Nanocarriers for Drug Delivery Applications

Nanomaterials ◽  
2020 ◽  
Vol 10 (5) ◽  
pp. 963 ◽  
Author(s):  
Omar Mertins ◽  
Patrick D. Mathews ◽  
Angelina Angelova
Keyword(s):  
Drug Delivery ◽  
Oral Delivery ◽  
Liquid Crystalline ◽  
Delivery Systems ◽  
Ph Sensitive ◽  
Water Soluble ◽  
Cubic Phase ◽  
Ph Responsive ◽  
X Ray ◽  
Lipid Fatty Acid

Nanostructure bicontinuous cubic phase self-assembled materials are receiving expanding applications as biocompatible delivery systems in various therapeutic fields. The functionalization of cubosome, spongosome, hexosome and liposome nanocarriers by pH-sensitive lipids and/or pH-sensitive polymer shells offers new opportunities for oral and topical drug delivery towards a new generation of cancer therapies. The electrochemical behavior of drug compounds may favor pH-triggered drug release as well. Here, we highlight recent investigations, which explore the phase behavior of mixed nonlamellar lipid/fatty acid or phospholipid systems for the design of pH-responsive and mucoadhesive drug delivery systems with sustained-release properties. X-ray diffraction and small-angle X-ray scattering (SAXS) techniques are widely used in the development of innovative delivery assemblies through detailed structural analyses of multiple amphiphilic compositions from the lipid/co-lipid/water phase diagrams. pH-responsive nanoscale materials and nanoparticles are required for challenging therapeutic applications such as oral delivery of therapeutic proteins and peptides as well as of poorly water-soluble substances. Perspective nanomedicine developments with smart cubosome nanocarriers may exploit compositions elaborated to overcome the intestinal obstacles, dual-drug loaded pH-sensitive liquid crystalline architectures aiming at enhanced therapeutic efficacy, as well as composite (lipid/polyelectrolyte) types of mucoadhesive controlled release colloidal cubosomal formulations for the improvement of the drugs’ bioavailability.

scholarly journals Smart Shear-Thinning Hydrogels as Injectable Drug Delivery Systems

Polymers ◽  
2018 ◽  
Vol 10 (12) ◽  
pp. 1317 ◽  
Author(s):  
Sadaf Samimi Gharaie ◽  
Seyed Dabiri ◽  
Mohsen Akbari
Keyword(s):  
Mechanical Properties ◽  
Drug Delivery ◽  
Total Solid ◽  
Shear Thinning ◽  
Ph Sensitive ◽  
Ph Responsive ◽  
Physiological Conditions ◽  
Optimum Formulation ◽  
Localized Drug Delivery ◽  
Sensitive Behavior

In this study, we fabricated and characterized a smart shear-thinning hydrogel composed of gelatin and laponite for localized drug delivery. We added chitosan (Chi) and poly N-isopropylacrylamide-co-Acrylic acid (PNIPAM) particles to the shear-thinning gel to render it pH-responsive. The effects of total solid weight and the percentage of laponite in a solid mass on the rheological behavior and mechanical properties were investigated to obtain the optimum formulation. The nanocomposite gel and particles were characterized using Fourier-transform infrared spectroscopy (FTIR), scanning electron microscope (SEM), zeta potential, and dynamic light scattering techniques. Finally, release related experiment including degradability, swelling and Rhodamine B (Rd) release at various pH were performed. The results suggest that incorporation of silicate nanoplatelets in the gelatin led to the formation of the tunable porous composite, with a microstructure that was affected by introducing particles. Besides, the optimum formulation possessed shear-thinning properties with modified rheological and mechanical properties which preserved its mechanical properties while incubated in physiological conditions. The release related experiments showed that the shear-thinning materials offer pH-sensitive behavior so that the highest swelling ratio, degradation rate, and Rd release were obtained at pH 9.18. Therefore, this nanocomposite gel can be potentially used to develop pH-sensitive systems.

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