Chitosan-decorated calcium hydroxide microcapsules with pH-triggered release for endodontic applications

2015 ◽  
Vol 3 (45) ◽  
pp. 8884-8891 ◽  
Author(s):  
Xiaoman Li ◽  
Bing Han ◽  
Xiaoyan Wang ◽  
Xuejun Gao ◽  
Fuxin Liang ◽  
...  
Keyword(s):  
Calcium Hydroxide ◽  
Root Canal ◽  
Drug Toxicity ◽  
Apical Periodontitis ◽  
Canal System ◽  
Triggered Release ◽  
Root Canal Therapy ◽  
Root Canal System ◽  
Immune Factors

The treatment of apical periodontitis (AP) remains challenging because traditional root canal therapy (RCT) outcomes are limited by the complexity of the root canal system, drug toxicity, and host immune factors.

scholarly journals Microbial infection and its control in cases of symptomatic apical periodontitis: A review

Medicina ◽  
2008 ◽  
Vol 45 (5) ◽  
pp. 343 ◽  
Author(s):  
Neringa Skučaitė ◽  
Vytautė Pečiulienė ◽  
Vita Mačiulskienė
Keyword(s):  
Host Resistance ◽  
Root Canal ◽  
Susceptibility Testing ◽  
Apical Periodontitis ◽  
Microbial Infection ◽  
Canal System ◽  
Root Canal Therapy ◽  
Dental Origin ◽  
Root Canal System ◽  
Selection Of

Apical periodontitis is an inflammation of dental periapical tissues developed as a response to colonization of microorganisms in root canal system. Etiology of periapical pathology is associated with different species of microorganisms that are not fully defined yet. The changes in the composition of root canal microbiota as well as other factors, such as host resistance to various infections and concomitant viral infection, etc., can influence development of the symptomatic apical periodontitis. Etiology of disease is reviewed in this article. The purpose of treatment of symptomatic apical periodontitis is to eliminate the infection in root canal system and to obtain relief of symptoms. It can be done by conventional root canal therapy, which can be combined with anti-inflammatory medication. Indications for antibiotic therapy in such cases are limited to particular occasions, which are considered in article. Nevertheless, findings show that usually dentists prescribe antibiotics improperly in clinical practice. It can render drugs ineffective against diseases of dental origin as well as against potentially fatal infectious diseases. Selection of antibiotics for the treatment of root canal infections is reviewed in this article. Importance of antimicrobial susceptibility testing is emphasized. There is a need for more research on microbial causes and interactions in different forms of apical periodontitis to improve diagnosis and treatment.

scholarly journals Influence Of Genetic Polymorphisms In Genes Of Bone Remodeling And Angiogenesis Process In The Apical Periodontitis

2018 ◽  
Vol 29 (2) ◽  
pp. 179-183 ◽  
Author(s):  
Jardel Francisco Mazzi-Chaves ◽  
Igor Bassi Ferreira Petean ◽  
Isadora Mello Vilarinho Soares ◽  
Alessandro Guimarães Salles ◽  
Lívia Azeredo Alves Antunes ◽  
...  
Keyword(s):  
Genetic Polymorphisms ◽  
Root Canal ◽  
Apical Periodontitis ◽  
Genotype Distribution ◽  
Canal System ◽  
Root Canal Therapy ◽  
Angiogenesis Process ◽  
Root Canal System ◽  
Genotype And Allele Frequencies

Abstract Persistent apical periodontitis (AP) is a situation involving an inflammatory and immune response caused mainly by anaerobic polymicrobial infection of the root canal system and the outcome and follow-up of the root canal treatment has been reported as intimately related to host response. The apical periodontitis repair might be associated with genetic polymorphisms. This study aimed to evaluate the association between HIF1A genetic polymorphisms (rs2301113 and rs2057482) with PAP in Brazilian patients. Subjects with at least 1 year of follow-up after root canal therapy (RCT) were recalled. Sixty-four subjects with signs/symptoms of PAP and 84 subjects with root canal-treated teeth exhibiting healthy perirradicular tissues (healed) were included. Genomic DNA was extracted from saliva and used for HIF1A genotyping by real-time PCR. Genotype and allele frequencies were compared by c2 or Fisher’s exact tests and odds ratio was implemented, using Epi Info 3.5.2. All tests were performed with an established alpha of 0.05. There was no association between allele and genotype distribution for HIF1As polymorphisms and PAP (p>0.05). The genetic polymorphisms in HIF1A were not associated with persistent apical periodontitis.

scholarly journals Evaluation of Interference of Calcium Hydroxide-based Intracanal Medication in Filling Root Canal Systems

2011 ◽  
Vol 12 (5) ◽  
pp. 368-371 ◽  
Author(s):  
Matheus Melo Pithon ◽  
Deyla Duarte Vilela ◽  
Manoel Matos Neto ◽  
Alexandre Mascarenhas Villela
Keyword(s):  
Calcium Hydroxide ◽  
Clinical Significance ◽  
Root Canal ◽  
Canal System ◽  
Root Canals ◽  
Anterior Teeth ◽  
Knowing That ◽  
Group I ◽  
Canal Systems ◽  
Root Canal System

ABSTRACT Aim To evaluate the interference of the intracanal medication Calen® (SSWhite, São Paulo, Brazil) on the filling of simulated lateral canals. Materials and methods Twenty human anterior teeth were used. Before the endodontic filling procedures the access of cavity was made, and after this root canals were made in all the teeth to simulate the presence of lateral canals. After preparation, the teeth were randomly divided into two groups (n=10). In group I, the root canal system was filled directly after chemicalmechanical preparation; in group II, endodontic treatment was performed in multiple sessions, and after preparation the calcium hydroxide-based intracanal medication Calen® was inserted. After the period of 7 days, the root canals were vigorously irrigated and then they were filled. Next, the teeth were radiographed to verify the quality of the filling. Results The results demonstrated that the teeth treated in a single session, without calcium hydroxide medication, presented 47 canals out of 60 with radiographic evidence of filling, whereas the teeth in which intracanal medication was used, only 07 presented a radiographic image compatible with filling (p < 0.05). Conclusion The use of the calcium hydroxide-based medication Calen made it difficult to obtain a hermetic filling of the root canal system. Clinical significance The clinical significance of this work basing on the fact that once the dentist knowing that property obliteration of calcium hydroxide can be taken care when they are used in the presence of lateral canals. How to cite this article Vilela DD, Neto MM, Villela AM, Pithon MM. Evaluation of Interference of Calcium Hydroxide-based Intracanal Medication in Filling Root Canal Systems . J Contemp Dent Pract 2011;12(5):368-371.

scholarly journals Water uptake and solubility of Acroseal sealer in comparison with Apexit and AH Plus sealers in Hank’s solution

2011 ◽  
Vol 139 (9-10) ◽  
pp. 579-582 ◽  
Author(s):  
Djurica Grga ◽  
Bojan Dzeletovic ◽  
Vesna Miletic ◽  
Marija Damjanov
Keyword(s):  
Calcium Hydroxide ◽  
Root Canal ◽  
Physical Property ◽  
Weight Changes ◽  
Canal System ◽  
Ah Plus ◽  
Root Canal System ◽  
Hank’S Solution ◽  
Low Solubility ◽  
One Way Anova

Introduction. The function of root canal fillings is to seal the root canal system. The important physical property necessary for sealers to achieve this is low solubility. However, any therapeutic effect of calcium hydroxide-based sealers is dependent on the calcium hydroxide being in ionized form, which implies that the material must be at least partly soluble. Objective. The objective of our study was to compare weight changes of Acroseal and Apexit, conventional calcium hydroxide-based sealer and AH Plus, epoxy-amine resin sealer in Hank?s solution at different exposure times. Methods. The standardized samples of each material were weighed and immersed in the Hank?s solution for 1 h, 24 h, 96 h, 14 days and 28 days. After these exposure times, they were removed, dried, and weighed again. Mean weight changes were determined and the differences between sealers were analysed statistically using a one-way ANOVA. Results. The highest differences in mass were observed in Apexit, 1.52%, and were significantly different from Acroseal, 0.93% (p<0.05) and AH Plus, 0.45% (p<0.05). There were no significant differences between Acroseal and AH Plus, except for 96 h period. Conclusion. Under the conditions of our study, it may be concluded that the Acroseal sealer presented the behaviour more like epoxy-based material, AH Plus, than calcium hydroxide sealer, Apexit.

The Apical Root Canal System of Teeth with Posttreatment Apical Periodontitis: Correlating Microbiologic, Tomographic, and Histopathologic Findings

2020 ◽  
Vol 46 (9) ◽  
pp. 1195-1203 ◽  
Author(s):  
José F. Siqueira ◽  
Henrique S. Antunes ◽  
Alejandro R. Pérez ◽  
Flávio R.F. Alves ◽  
Ibrahimu Mdala ◽  
...  
Keyword(s):  
Root Canal ◽  
Apical Periodontitis ◽  
Canal System ◽  
Root Canal System ◽  
Histopathologic Findings ◽  
Posttreatment Apical Periodontitis

scholarly journals Endodontic Disinfection for Orthograde Root Canal Treatment in Veterinary Dentistry

2020 ◽  
Vol 37 (1) ◽  
pp. 35-40
Author(s):  
Laura Sasser
Keyword(s):  
Sodium Hypochlorite ◽  
Root Canal ◽  
Ethylenediaminetetraacetic Acid ◽  
Endodontic Treatment ◽  
Smear Layer ◽  
Canal System ◽  
Root Canal Therapy ◽  
Complex Anatomy ◽  
Root Canal System ◽  
Necrotic Debris

Pulp debridement and disinfection in the pulp cavity is a critical step in achieving a successful root canal therapy. Microorganisms remaining in the root canal system after endodontic treatment are a main cause of root canal failure. The challenges faced in endodontic disinfection include the complex anatomy of the root canal system, the existence of a biofilm within the root canal, and the creation of a problematic smear layer during instrumentation of the canal. Historically, sodium hypochlorite and ethylenediaminetetraacetic acid have been utilized as irrigants and still remain as the most effective disinfectants due to their synergistic abilities to eradicate microorganisms, dissolve necrotic debris, and remove the smear layer and biofilm. This article addresses challenges in endodontic disinfection, objectives of endodontic irrigants, properties of an ideal irrigant, currently used irrigants, and irrigant delivery systems utilized in veterinary dentistry.

scholarly journals Microbiota in the apical root canal system of tooth with apical periodontitis

BMC Genomics ◽  
2019 ◽  
Vol 20 (S2) ◽  
Author(s):  
Wenhao Qian ◽  
Ting Ma ◽  
Mao Ye ◽  
Zhiyao Li ◽  
Yuanhua Liu ◽  
...  
Keyword(s):  
Root Canal ◽  
Apical Periodontitis ◽  
Canal System ◽  
Root Canal System

scholarly journals Non Surgical Management of Large Periapical Lesions of Endodontic Origin: A Case Series

2014 ◽  
Vol 8 (3) ◽  
pp. 172-175 ◽  
Author(s):  
A Gupta ◽  
V Goyal ◽  
S Bala ◽  
J Duhan ◽  
S Hans
Keyword(s):  
Calcium Hydroxide ◽  
Root Canal ◽  
Tissue Repair ◽  
Antibacterial Properties ◽  
Case Series ◽  
Tissue Formation ◽  
Canal System ◽  
Periapical Lesions ◽  
Root Canal System ◽  
Total Elimination

ABSTRACT The success of root canal treatment is based on total elimination of root canal content, thorough cleaning, shaping and obturation of root canal system. Calcium hydroxide is recommended as intra-canal medicament because of its antibacterial properties, tissue dissolving ability, inhibition of tooth resorption and indication of tissue repair by hard tissue formation. The present case series highlights the use of calcium hydroxide as an inter appointment endodontic dressing for management of large periapical radiolucency and periodically reviewed. Thus the non surgical healing of large periapical lesions provided favourable clinical and radiographic response.

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