Synthesis and characterization of biodegradable lysine-based waterborne polyurethane for soft tissue engineering applications

2016 ◽  
Vol 4 (11) ◽  
pp. 1682-1690 ◽  
Author(s):  
Hongye Hao ◽  
Jingyu Shao ◽  
Ya Deng ◽  
Shan He ◽  
Feng Luo ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Wound Healing ◽  
Soft Tissue ◽  
Tissue Repair ◽  
Waterborne Polyurethane ◽  
Synthesis And Characterization ◽  
Soft Tissue Repair ◽  
Waterborne Polyurethanes ◽  
Soft Tissue Engineering

Light-crosslinking waterborne polyurethanes (LWPUs) based on lysine possess appropriate elasticity for soft tissue repair, and can induce macrophages into a wound healing phenotype.

Synthesis and characterization of an enzyme-degradable zwitterionic dextran hydrogel

RSC Advances ◽  
2016 ◽  
Vol 6 (37) ◽  
pp. 30862-30866 ◽  
Author(s):  
Haiyan Wu ◽  
Huifeng Wang ◽  
Fang Cheng ◽  
Fujian Xu ◽  
Gang Cheng
Keyword(s):  
Tissue Engineering ◽  
Soft Tissue ◽  
Matrix Metalloproteinase ◽  
Protein Adsorption ◽  
Cell Attachment ◽  
Synthesis And Characterization ◽  
Engineering Applications ◽  
Soft Tissue Engineering ◽  
Nonspecific Protein Adsorption

A matrix metalloproteinase peptide cross-linked dextran hydrogel was synthesized. Dextran was modified with carboxybetaine to resist nonspecific protein adsorption and cell attachment. The degradable hydrogel is a good candidate for soft tissue engineering applications.

Design and characterization of poly(glycerol-sebacate)-co-poly(caprolactone) (PGS-co-PCL) and its nanocomposites as novel biomaterials: The promising candidate for soft tissue engineering

2020 ◽  
Vol 138 ◽  
pp. 109985
Author(s):  
Mostafa Rostamian ◽  
Mohammad Reza Kalaee ◽  
Shiva Raeisi Dehkordi ◽  
Mahyar Panahi-Sarmad ◽  
Mahtab Tirgar ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Soft Tissue ◽  
Promising Candidate ◽  
Soft Tissue Engineering ◽  
Poly Caprolactone

scholarly journals Development of Photocrosslinkable Urethane-Doped Polyester Elastomers for Soft Tissue Engineering

2011 ◽  
Vol 1 (1) ◽  
pp. 18-31 ◽  
Author(s):  
Yi Zhang ◽  
Richard T. Tran ◽  
Dipendra Gyawali ◽  
Jian Yang
Keyword(s):  
Mechanical Properties ◽  
Tissue Engineering ◽  
Soft Tissue ◽  
Hexamethylene Diisocyanate ◽  
Elongation At Break ◽  
Thermally Induced ◽  
Molar Ratios ◽  
3D Network ◽  
Soft Tissue Engineering

Finding an ideal biomaterial with the proper mechanical properties and biocompatibility has been of intense focus in the field of soft tissue engineering. This paper reports on the synthesis and characterization of a novel crosslinked urethane-doped polyester elastomer (CUPOMC), which was synthesized by reacting a previously developed photocrosslinkable poly (octamethylene maleate citrate) (POMC) prepolymers (pre-POMC) with 1,6-hexamethylene diisocyanate (HDI) followed by thermo- or photo-crosslinking polymerization. The mechanical properties of the CUPOMCs can be tuned by controlling the molar ratios of pre-POMC monomers, and the ratio between the prepolymer and HDI. CUPOMCs can be crosslinked into a 3D network through polycondensation or free radical polymerization reactions. The tensile strength and elongation at break of CUPOMC synthesized under the known conditions range from 0.73±0.12MPa to 10.91±0.64MPa and from 72.91±9.09% to 300.41±21.99% respectively. Preliminary biocompatibility tests demonstrated that CUPOMCs support cell adhesion and proliferation. Unlike the pre-polymers of other crosslinked elastomers, CUPOMC pre-polymers possess great processability demonstrated by scaffold fabrication via a thermally induced phase separation method. The dual crosslinking methods for CUPOMC pre-polymers should enhance the versatile processability of the CUPOMC used in various conditions. Development of CUPOMC should expand the choices of available biodegradable elastomers for various biomedical applications such as soft tissue engineering.

Bioactive glasses in wound healing: hope or hype?

2017 ◽  
Vol 5 (31) ◽  
pp. 6167-6174 ◽  
Author(s):  
Shiva Naseri ◽  
William C. Lepry ◽  
Showan N. Nazhat
Keyword(s):  
Wound Healing ◽  
Soft Tissue ◽  
Tissue Regeneration ◽  
Tissue Repair ◽  
Great Promise ◽  
Mineralized Tissue ◽  
Bioactive Glasses ◽  
Soft Tissue Repair ◽  
Potential Applications

Bioactive glasses have long been investigated in mineralized tissue regeneration, but recently their potential applications in soft tissue repair, and in particular wound healing, have demonstrated great promise.

Functional Tissue Engineering for Soft Tissue Repair : Matching In Vivo Biomechanics(International Workshop 3)

2006 ◽  
Vol 2005.18 (0) ◽  
pp. 4-5
Author(s):  
David L. Butler ◽  
Natalia Juncosa-Melvin ◽  
John West ◽  
Jason Shearn ◽  
Marc Galloway ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Soft Tissue ◽  
Tissue Repair ◽  
International Workshop ◽  
Soft Tissue Repair ◽  
Functional Tissue Engineering ◽  
Functional Tissue

scholarly journals Bioactive Materials for Soft Tissue Repair

2021 ◽  
Vol 9 ◽  
Author(s):  
Elisa Mazzoni ◽  
Maria Rosa Iaquinta ◽  
Carmen Lanzillotti ◽  
Chiara Mazziotta ◽  
Martina Maritati ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Soft Tissue ◽  
Regenerative Medicine ◽  
Tissue Repair ◽  
Soft Tissues ◽  
High Efficiency ◽  
Calcium Phosphates ◽  
Tissue Growth ◽  
Tissue Healing ◽  
Soft Tissue Engineering

Over the past decades, age-related pathologies have increased abreast the aging population worldwide. The increased age of the population indicates that new tools, such as biomaterials/scaffolds for damaged tissues, which display high efficiency, effectively and in a limited period of time, for the regeneration of the body's tissue are needed. Indeed, scaffolds can be used as templates for three-dimensional tissue growth in order to promote the tissue healing stimulating the body's own regenerative mechanisms. In tissue engineering, several types of biomaterials are employed, such as bioceramics including calcium phosphates, bioactive glasses, and glass–ceramics. These scaffolds seem to have a high potential as biomaterials in regenerative medicine. In addition, in conjunction with other materials, such as polymers, ceramic scaffolds may be used to manufacture composite scaffolds characterized by high biocompatibility, mechanical efficiency and load-bearing capabilities that render these biomaterials suitable for regenerative medicine applications. Usually, bioceramics have been used to repair hard tissues, such as bone and dental defects. More recently, in the field of soft tissue engineering, this form of scaffold has also shown promising applications. Indeed, soft tissues are continuously exposed to damages, such as burns or mechanical traumas, tumors and degenerative pathology, and, thereby, thousands of people need remedial interventions such as biomaterials-based therapies. It is known that scaffolds can affect the ability to bind, proliferate and differentiate cells similar to those of autologous tissues. Therefore, it is important to investigate the interaction between bioceramics and somatic/stem cells derived from soft tissues in order to promote tissue healing. Biomimetic scaffolds are frequently employed as drug-delivery system using several therapeutic molecules to increase their biological performance, leading to ultimate products with innovative functionalities. This review provides an overview of essential requirements for soft tissue engineering biomaterials. Data on recent progresses of porous bioceramics and composites for tissue repair are also presented.

scholarly journals Biology of soft tissue repair: gingival epithelium in wound healing and attachment to the tooth and abutment surface

2019 ◽  
Vol 38 ◽  
pp. 63-78 ◽  
Author(s):  
S Gibbs ◽  
◽  
S Roffel ◽  
M Meyer ◽  
A Gasser
Keyword(s):  
Wound Healing ◽  
Soft Tissue ◽  
Tissue Repair ◽  
Soft Tissue Repair ◽  
Gingival Epithelium
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