Preparation, characterization and in vitro photodynamic therapy of a pyropheophorbide-a-conjugated Fe3O4 multifunctional magnetofluorescence photosensitizer

RSC Advances ◽  
2016 ◽  
Vol 6 (44) ◽  
pp. 37610-37620 ◽  
Author(s):  
Jianjun Cheng ◽  
Guanghui Tan ◽  
Wenting Li ◽  
Jinghua Li ◽  
Zhiqiang Wang ◽  
...  

Core–shell structure magneto-fluorescence chlorin pyropheorbide-a photosensitizer (MFNPs) with good water-dispersity and strong superparamagnetic for photodynamic therapy.

Materials ◽  
2021 ◽  
Vol 14 (13) ◽  
pp. 3660
Author(s):  
Zhen Zhang ◽  
Xiao-Lian Zhang ◽  
Bin Li

Photodynamic therapy (PDT) has been reported as a possible pathway for the treatment of tumors. The exploration for promising PDT systems thus attracts continuous research efforts. This work focused on an ordered core–shell structure encapsulated by mesoporous SiO2 with the upconverting emission property following a surfactant-assisted sol–gel technique. The mesoporous silica shell possessed a high surface area-to-volume ratio and uniform distribution in pore size, favoring photosensitizer (rose bengal) loading. Simultaneously, upconverting nanocrystals were synthesized and used as the core. After modification via hydrophobic silica, the hydrophobic upconverting nanocrystals became hydrophilic ones. Under near-infrared (NIR) light irradiation, the nanomaterials exhibited strong green upconverting luminescence so that rose bengal could be excited to produce singlet oxygen. The photodynamic therapy (PDT) feature was evaluated using a 1O2 fluorescent indicator. It was found that this core–shell structure generates 1O2 efficiently. The novelty of this core–shell structure was the combination of upconverting nanocrystals with a mesoporous SiO2 shell so that photosensitizer rose bengal could be effectively adsorbed in the SiO2 shell and then excited by the upconverting core.


2015 ◽  
Vol 53 (4) ◽  
pp. 287-293
Author(s):  
Byung-Hyun Choi ◽  
Young Jin Kang ◽  
Sung-Hun Jung ◽  
Yong-Tae An ◽  
Mi-Jung Ji

2015 ◽  
Vol 30 (6) ◽  
pp. 610 ◽  
Author(s):  
ZHENG Guo-Qiang ◽  
ZHANG Wen-Chao ◽  
XU Xing ◽  
SHEN Rui-Qi ◽  
DENG Ji-Ping ◽  
...  

2010 ◽  
Vol 107 (10) ◽  
pp. 104106 ◽  
Author(s):  
L. P. Curecheriu ◽  
M. T. Buscaglia ◽  
V. Buscaglia ◽  
L. Mitoseriu ◽  
P. Postolache ◽  
...  

Author(s):  
Linli Zhu ◽  
Chen Hao ◽  
Saisai Zhou ◽  
Xiaohong Wang ◽  
Tiantian Zhou ◽  
...  

2021 ◽  
Vol 31 (1) ◽  
pp. 24-26
Author(s):  
Galina M. Kuz’micheva ◽  
Olesya I. Timaeva ◽  
Irina P. Chikhacheva ◽  
Roman V. Svetogorov ◽  
Ratibor G. Chumakov ◽  
...  

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