Au nanoshell-coated superparamagnetic Fe3O4–silica composite nanoparticles with surface-modification of an activatable cell-penetrating peptide for tumor-targeted multimode bioimaging and photothermal therapy

RSC Advances ◽  
2016 ◽  
Vol 6 (88) ◽  
pp. 85587-85594
Author(s):  
Yunfang Jiang ◽  
Qianyu Zhang ◽  
Xinghua Liu ◽  
Yifu Chen ◽  
Li Wang ◽  
...  
Keyword(s):  
Surface Modification ◽  
Photothermal Therapy ◽  
Composite Nanoparticles ◽  
Cell Penetrating Peptide ◽  
Tumor Site ◽  
Site Specific ◽  
Silica Composite ◽  
Cell Penetrating ◽  
Surface Modified

The superparamagnetic Fe3O4–silica composite nanoparticles coated with Au nanoshells were prepared and subsequently surface-modified with PEG conjugated ACPP for realizing the tumor site-specific multimode bioimaging and photothermal therapy.

scholarly journals Control of protein palmitoylation by regulating substrate recruitment to a zDHHC-protein acyltransferase

2020 ◽  
Vol 3 (1) ◽  
Author(s):  
Fiona Plain ◽  
Jacqueline Howie ◽  
Jennifer Kennedy ◽  
Elaine Brown ◽  
Michael J. Shattock ◽  
...  
Keyword(s):  
Cell Penetrating Peptide ◽  
Amphipathic Helix ◽  
Post Translational Modification ◽  
Site Specific ◽  
Cellular Processes ◽  
Na Pump ◽  
Protein Palmitoylation ◽  
Therapeutic Gain ◽  
Cell Penetrating ◽  
A Cell

AbstractAlthough palmitoylation regulates numerous cellular processes, as yet efforts to manipulate this post-translational modification for therapeutic gain have proved unsuccessful. The Na-pump accessory sub-unit phospholemman (PLM) is palmitoylated by zDHHC5. Here, we show that PLM palmitoylation is facilitated by recruitment of the Na-pump α sub-unit to a specific site on zDHHC5 that contains a juxtamembrane amphipathic helix. Site-specific palmitoylation and GlcNAcylation of this helix increased binding between the Na-pump and zDHHC5, promoting PLM palmitoylation. In contrast, disruption of the zDHHC5-Na-pump interaction with a cell penetrating peptide reduced PLM palmitoylation. Our results suggest that by manipulating the recruitment of specific substrates to particular zDHHC-palmitoyl acyl transferases, the palmitoylation status of individual proteins can be selectively altered, thus opening the door to the development of molecular modulators of protein palmitoylation for the treatment of disease.

Cell-penetrating peptide modified AIE polymeric nanoparticles by miniemulsion polymerization and application for cell fluorescence imaging

2019 ◽  
Vol 10 (30) ◽  
pp. 4220-4228 ◽  
Author(s):  
Yaxin Hu ◽  
Xiaoqin Liang ◽  
Zeyan Zhuang ◽  
Zhihai Cao ◽  
Qi Qi ◽  
...  
Keyword(s):  
Fluorescence Imaging ◽  
Click Reaction ◽  
Polymeric Nanoparticles ◽  
Miniemulsion Polymerization ◽  
Cell Penetrating Peptide ◽  
Tat Peptides ◽  
Hiv Tat ◽  
Cell Penetrating ◽  
Surface Modified

AIE polymeric nanoparticles surface-modified with HIV Tat peptides for cell fluorescence imaging are efficiently prepared through miniemulsion polymerization, carbodiimide reaction, and thiol-maleimide click reaction in sequence.

Activatable Cell Penetrating Peptide-Conjugated Nanoparticles with Enhanced Permeability for Site-Specific Targeting Delivery of Anticancer Drug

2013 ◽  
Vol 24 (3) ◽  
pp. 419-430 ◽  
Author(s):  
Huimin Xia ◽  
Guangzhi Gu ◽  
Quanyin Hu ◽  
Zhongyang Liu ◽  
Mengyin Jiang ◽  
...  
Keyword(s):  
Anticancer Drug ◽  
Cell Penetrating Peptide ◽  
Site Specific ◽  
Specific Targeting ◽  
Cell Penetrating ◽  
Targeting Delivery

Induction of Spontaneous Liposome Adsorption by Exogenous Surface Modification with Cell-Penetrating Peptide-Conjugated Lipids

Langmuir ◽  
2021 ◽  
Author(s):  
Yuya Sato ◽  
Kenta Asawa ◽  
Tianwei Huang ◽  
Makoto Noiri ◽  
Naoko Nakamura ◽  
...  
Keyword(s):  
Surface Modification ◽  
Cell Penetrating Peptide ◽  
Cell Penetrating
Sign in / Sign up

Export Citation Format

Share Document