Development of dichloroacetamide pyrimidines as pyruvate dehydrogenase kinase inhibitors to reduce cancer cell growth: synthesis and biological evaluation

RSC Advances ◽  
2016 ◽  
Vol 6 (82) ◽  
pp. 78762-78767 ◽  
Author(s):  
Shao-Lin Zhang ◽  
Wen Zhang ◽  
Qingpin Xiao ◽  
Zheng Yang ◽  
Xiaohui Hu ◽  
...  
Keyword(s):  
Cell Growth ◽  
Cancer Cell ◽  
Pyruvate Dehydrogenase ◽  
Kinase Inhibitors ◽  
Biological Evaluation ◽  
Pyruvate Dehydrogenase Kinase ◽  
Cancer Cell Growth ◽  
Biological Assays ◽  
Synthesis And Biological Evaluation

The synthesis and biological assays were described herein to firstly identify a novel PDK1 inhibitor.

Biological evaluation of twenty-eight ferrocenyl tetrasubstituted olefins: Cancer cell growth inhibition, ROS production and hemolytic activity

2011 ◽  
Vol 46 (9) ◽  
pp. 3778-3787 ◽  
Author(s):  
Alane Cabral de Oliveira ◽  
Elizabeth A. Hillard ◽  
Pascal Pigeon ◽  
Danilo Damasceno Rocha ◽  
Felipe A.R. Rodrigues ◽  
...  
Keyword(s):  
Cell Growth ◽  
Growth Inhibition ◽  
Cancer Cell ◽  
Hemolytic Activity ◽  
Biological Evaluation ◽  
Ros Production ◽  
Cell Growth Inhibition ◽  
Cancer Cell Growth ◽  
Tetrasubstituted Olefins

scholarly journals Biphasic Regulation of Breast Cancer Cell Growth by Progesterone: Role of the Cyclin-Dependent Kinase Inhibitors, p21 and p27Kip1

1997 ◽  
Vol 11 (11) ◽  
pp. 1593-1607 ◽  
Author(s):  
Steve D. Groshong ◽  
Gareth I. Owen ◽  
Bryn Grimison ◽  
Irene E. Schauer ◽  
Maria C. Todd ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Growth ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Kinase Inhibitors ◽  
Cyclin Dependent Kinase ◽  
Cancer Cell Growth ◽  
Breast Cancer Cell Growth
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