Mechanical stimuli responsive and highly elastic biopolymer/nanoparticle hybrid microcapsules for controlled release

2016 ◽  
Vol 4 (24) ◽  
pp. 4278-4286 ◽  
Author(s):  
Raja Rajamanickam ◽  
Siyeon Baek ◽  
Kihak Gwon ◽  
Youngmin Hwang ◽  
Kwanwoo Shin ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Mechanical Stimuli ◽  
Stimuli Responsive ◽  
Drug Delivery Vehicles ◽  
Delivery Vehicles ◽  
Freezing Temperatures

Hybrid hollow capsules crosslinked at freezing temperatures that recover elastically after large, repetitive deformations as mechanical stimuli-responsive drug delivery vehicles.

scholarly journals Advances in Molecularly Imprinted Polymers as Drug Delivery Systems

Molecules ◽  
2021 ◽  
Vol 26 (12) ◽  
pp. 3589
Author(s):  
Rui Liu ◽  
Alessandro Poma
Keyword(s):  
Drug Delivery ◽  
Molecularly Imprinted Polymers ◽  
Drug Loading ◽  
Stimuli Responsive ◽  
Molecularly Imprinted ◽  
Imprinted Polymers ◽  
Drug Delivery Vehicles ◽  
The Past ◽  
Drug Molecules ◽  
Delivery Vehicles

Despite the tremendous efforts made in the past decades, severe side/toxic effects and poor bioavailability still represent the main challenges that hinder the clinical translation of drug molecules. This has turned the attention of investigators towards drug delivery vehicles that provide a localized and controlled drug delivery. Molecularly imprinted polymers (MIPs) as novel and versatile drug delivery vehicles have been widely studied in recent years due to the advantages of selective recognition, enhanced drug loading, sustained release, and robustness in harsh conditions. This review highlights the design and development of strategies undertaken for MIPs used as drug delivery vehicles involving different drug delivery mechanisms, such as rate-programmed, stimuli-responsive and active targeting, published during the course of the past five years.

Influence of the structural and textural properties of ordered mesoporous materials and hierarchical zeolitic supports on the controlled release of methylprednisolone hemisuccinate

2014 ◽  
Vol 2 (45) ◽  
pp. 7996-8004 ◽  
Author(s):  
R. A. García-Muñoz ◽  
V. Morales ◽  
M. Linares ◽  
P. E. González ◽  
R. Sanz ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Mesoporous Materials ◽  
Textural Properties ◽  
Effective Drug ◽  
Hierarchical Zeolite ◽  
Ordered Mesoporous Materials ◽  
Drug Delivery Vehicles ◽  
Ordered Mesoporous ◽  
Delivery Vehicles

Influence of structural and textural properties of mesostructured siliceous and hierarchical zeolite materials in designing effective drug delivery vehicles.

scholarly journals Magnetoliposomes: opportunities and challenges

2014 ◽  
Vol 6 (4) ◽  
Author(s):  
Christophe A. Monnier ◽  
David Burnand ◽  
Barbara Rothen-Rutishauser ◽  
Marco Lattuada ◽  
Alke Petri-Fink
Keyword(s):  
Drug Delivery ◽  
Magnetic Nanoparticles ◽  
Stimuli Responsive ◽  
Magnetic Fluid Hyperthermia ◽  
Drug Delivery Vehicles ◽  
Current State ◽  
New Concepts ◽  
Delivery Vehicles ◽  
Embedded Nanoparticles ◽  
Theoretical Considerations

AbstractCombining liposomes with magnetic nanoparticles is an intriguing approach to create multifunctional vesicles for medical applications, which range from controlled drug delivery vehicles to diagnostic imaging enhancers. Over the past decade, significant effort has been invested in developing such hybrids – widely known as magnetoliposomes – and has led to numerous new concepts. This review provides an overview on of the current state of the art in this field. The concept of magnetic fluid hyperthermia and stimuli-responsive nanoparticles for drug delivery is briefly recapitulated. The materials needed for these hybrids are addressed as well. The three typically followed approaches to associate magnetic nanoparticles to the liposomes are described and discussed more in detail. The final chapters are dedicated to the analytical methods used to characterize these hybrids and to theoretical considerations relevant for bilayer-embedded nanoparticles.

scholarly journals Metal-Organic Frameworks for Drug Delivery Applications

2021 ◽  
pp. 139-170
Author(s):  
Doaa Ahmed Ghareeb ◽  
Nessma Magdy Nasr
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Drug Delivery Systems ◽  
Metal Organic Frameworks ◽  
Stimuli Responsive ◽  
Surface Areas ◽  
Wide Range ◽  
Metal Organic ◽  
Delivery Vehicles ◽  
Structural Aspects

Metal-organic frameworks (MOFs) are based on metals and organic linkers; they possess large surface areas, suitable pore size and shape, wide range of chemical composition, and functionalized pore surface, which enable them for possible applications as delivery vehicles for therapeutic agents. The challenges include not only the development of new solids but also continuous improvements in the formulation and processing of the materials, including modifying the morphology and shape of the frameworks to fit the proposed applications of drug delivery. This chapter discussed enormous MOF-based stimuli responsive drug delivery systems, and considerable achievements have been made as a new avenue for drug delivery, their structural aspects, their applications in the controlled release of the drugs, and future view for development of drug controlled release researches using MOFs. Among the properties that must be developed and approved are the materials' toxicology, stability, their reproducibility of manufacture of MOFs in body's liquid, and pharmacokinetics of drug-loaded MOFs.

Physical stimuli-responsive liposomes and polymersomes as drug delivery vehicles based on phase transitions in the membrane

Nanoscale ◽  
2018 ◽  
Vol 10 (15) ◽  
pp. 6781-6800 ◽  
Author(s):  
Yangwei Deng ◽  
Jun Ling ◽  
Min-Hui Li
Keyword(s):  
Drug Delivery ◽  
Phase Transitions ◽  
Drug Release ◽  
Liquid Crystalline ◽  
Stimuli Responsive ◽  
Physical Stimulation ◽  
Drug Delivery Vehicles ◽  
Liquid Crystalline Phases ◽  
Physical Stimuli ◽  
Delivery Vehicles

Crystalline and liquid crystalline phases in the membrane lead to intriguing morphologies of vesicles for drug release upon physical stimulation.

scholarly journals Corrigendum to “Exosomes as drug delivery vehicles for Parkinson's disease therapy” [Journal of Controlled Release 207, (2015) 18–30]

2021 ◽  
Vol 339 ◽  
pp. 232-234
Author(s):  
Matthew J. Haney ◽  
Natalia L. Klyachko ◽  
Yuling Zhao ◽  
Richa Gupta ◽  
Evgeniya G. Plotnikova ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Drug Delivery ◽  
Parkinson's Disease ◽  
Controlled Release ◽  
Drug Delivery Vehicles ◽  
Disease Therapy ◽  
Delivery Vehicles

Nano-Imprint Fabrication of Injectable, Stimuli-Responsive Drug Delivery Vehicles

2005 ◽  
Author(s):  
Luz Cristal S. Glangchai ◽  
Li Shi ◽  
Krishnendu Roy
Keyword(s):  
Drug Delivery ◽  
Physiological Signals ◽  
Stimuli Responsive ◽  
Drug Delivery Vehicles ◽  
Nano Fabrication ◽  
Release Drug ◽  
Delivery Vehicles ◽  
Stimuli Responsive Polymer ◽  
Drug Delivery Devices ◽  
Nano Imprint

Nanofabrication techniques are developed to create well-defined and characterized drug delivery devices that overcome the limitations of current methods. Our approach is to use novel, top-down nano-fabrication technologies, including thermal nano-imprinting and step-and flash imprint lithography (S-FIL), coupled with stimuli-responsive polymer membranes to develop injectable nanocontainers that can release drug only in response to specific physiological signals at specific cellular locations.

Dendrimers: General Aspects, Applications and Structural Exploitations as Prodrug/Drug-delivery Vehicles in Current Medicine

2018 ◽  
Vol 18 (5) ◽  
pp. 439-457 ◽  
Author(s):  
Merina Mariyam ◽  
Kajal Ghosal ◽  
Sabu Thomas ◽  
Nandakumar Kalarikkal ◽  
Mahima S. Latha
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Vehicles ◽  
Delivery Vehicles ◽  
General Aspects

Novel Phospholipid-Based Labrasol Nanomicelles Loaded Flavonoids for Oral Delivery with Enhanced Penetration and Anti-Brain Tumor Efficiency

2020 ◽  
Vol 17 (3) ◽  
pp. 229-245
Author(s):  
Gang Wang ◽  
Junjie Wang ◽  
Rui Guan
Keyword(s):  
Drug Delivery ◽  
Brain Tumor ◽  
Oral Delivery ◽  
Safe Delivery ◽  
Drug Delivery Vehicles ◽  
Therapeutic Benefits ◽  
Delivery Vehicles ◽  
The Brain

Background: Owing to the rich anticancer properties of flavonoids, there is a need for their incorporation into drug delivery vehicles like nanomicelles for safe delivery of the drug into the brain tumor microenvironment. Objective: This study, therefore, aimed to prepare the phospholipid-based Labrasol/Pluronic F68 modified nano micelles loaded with flavonoids (Nano-flavonoids) for the delivery of the drug to the target brain tumor. Methods: Myricetin, quercetin and fisetin were selected as the initial drugs to evaluate the biodistribution and acute toxicity of the drug delivery vehicles in rats with implanted C6 glioma tumors after oral administration, while the uptake, retention, release in human intestinal Caco-2 cells and the effect on the brain endothelial barrier were investigated in Human Brain Microvascular Endothelial Cells (HBMECs). Results: The results demonstrated that nano-flavonoids loaded with myricetin showed more evenly distributed targeting tissues and enhanced anti-tumor efficiency in vivo without significant cytotoxicity to Caco-2 cells and alteration in the Trans Epithelial Electric Resistance (TEER). There was no pathological evidence of renal, hepatic or other organs dysfunction after the administration of nanoflavonoids, which showed no significant influence on cytotoxicity to Caco-2 cells. Conclusion: In conclusion, Labrasol/F68-NMs loaded with MYR and quercetin could enhance antiglioma effect in vitro and in vivo, which may be better tools for medical therapy, while the pharmacokinetics and pharmacodynamics of nano-flavonoids may ensure optimal therapeutic benefits.

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