Preparation of Composite Metal-Organic Frameworks

In recent years, metal-organic frameworks (MOFs)-derived composites have emanated as a significant class of substantial materials with specific functional characteristics such as flexibility, high porosity, and diverse composition. Specific chemical modifications can also endow MOFs with specific functionality by offering the possibility of manufacturing all new generation of sensing devices. As on comparison with pure MOFs, the mix up of MOFs with matrix materials(e.g., metal nanoparticles, quantum dots, molecular species, enzymes, silica, and polymers) or functional species not only exhibits enhanced properties, but also widens its applications to modern field of heterogeneous catalysis, gas separation, potential hydrogen storage material and many others due to its high adsorption nature and excellent reversibility kinetics as in result reveals its various undefined attributes, such as reproducible syntheses, amenability to scale-up and chemical modification due to interactions of the functional matrix or species with the MOFs structures.

Metal-Organic Frameworks for Drug Delivery Applications

Metal-organic frameworks (MOFs) are based on metals and organic linkers; they possess large surface areas, suitable pore size and shape, wide range of chemical composition, and functionalized pore surface, which enable them for possible applications as delivery vehicles for therapeutic agents. The challenges include not only the development of new solids but also continuous improvements in the formulation and processing of the materials, including modifying the morphology and shape of the frameworks to fit the proposed applications of drug delivery. This chapter discussed enormous MOF-based stimuli responsive drug delivery systems, and considerable achievements have been made as a new avenue for drug delivery, their structural aspects, their applications in the controlled release of the drugs, and future view for development of drug controlled release researches using MOFs. Among the properties that must be developed and approved are the materials' toxicology, stability, their reproducibility of manufacture of MOFs in body's liquid, and pharmacokinetics of drug-loaded MOFs.

Application of Metal-Organic Framework Adsorbents for Water Defluoridation

Defluoridation of drinking water is a subject of great concern due to the side effects of exposure to fluorine such as fluorosis, damage to vital organs such as the brain, liver, and kidney, among others. Fluorine finds itself in water resources both by geological and anthropogenic processes. Adsorption still remains the popular method of defluoridation and water treatment in general due to its inherent advantages such as simplicity and low-cost. This chapter discusses at length the up-to-date data on the preparation and adsorption capacities of metal-organic framework (MOF) materials as emerging adsorbents for sequestration of fluoride from water. Their synthesis, efficiency, and suggested adsorption mechanisms are examined. It is demonstrated that MOFs are low-cost, efficient, and environmentally benign alternative adsorbents for the removal of fluoride from aqueous solution.

Applications of Quartz Crystal Microbalances Modified With Metal Organic Frameworks

Metal-organic frameworks (MOFs) are versatile materials that are of interest due to their application and properties. MOFs are highly crystalline and porous materials; they are composed of organic bridging ligands, acting as linkers, and a three-dimensional (3D) network of metal ions that are secondary building units. Since the MOFs have a high surface area, high porosity, tunable topography, and their structures are quite diverse, these materials are used in process of separation/purification, gas/energy storage, drug delivery, catalysis, and chemical sensors. Since the MOFs can be modified to selectively adsorb chemical species, they can be used as sensitive layer for modification of sensors. This process allows the sensor to detect the target analyte. Quartz crystal microbalances (QCMs) are highly sensitive mass sensors. In this chapter, the authors review the literature related to QCMs modified with MOFs. In particular, the relationship between target analyte, class of MOF, and instrument used for measurement of frequency variations.

Metal-Organic Frameworks

In the field of bioinorganic chemistry, porosity has been explored for the development of metal-organic frameworks (MOFs), innovative polymers, or networks composed of metal centers that stabilize organic molecules with high contact surface and well-defined crystalline structures. MOFs have also been investigated for drug therapies due to their high loading capacity, thermal stability, low electrical conductivity, biodegradability, biocompatibility, easy functionalization, and size considered adequate to control drug release in vivo. MOFs can be sensitive to variations in pH, magnetism, temperature, pressure, light, and humidity, making them desirable for vectorizing extended release systems. Among the most investigated pharmacological groups for association with MOFs are anti-inflammatory and antineoplasic drugs. Here the authors explore the recent advances of MOFs-based drug delivery systems, their current limitations, and discuss the evidences towards their potential clinical use.

Luminescent Metal-Organic Frameworks-Based Sensors for Environmentally Toxic Analytes

Different metal ions and anions are crucial for the life of organisms, but their excessive intake or deficiency cause various physiological abnormalities or diseases. Toxic metal ions such as Hg2+, Cr6+, Cd2+, explosive nitroaromatic compounds, and volatile organic compounds are widely used in agriculture, rocket fuels, and industry, but they cause severe effects on human health and environmental change. Hence, sensing and identification of these analytes are important for life, health, and environment protection. Recently, metal-organic frameworks (MOFs) have been extensively explored as luminescent sensors due to their unique crystallinity, structural diversity, tunable porosity, and functional groups. This chapter reviewed the origin of luminescent of MOFs and its applications as luminescent sensors for detecting different environmentally toxic analytes such as metal ions, anions, nitroexplosives, and volatile organic compounds. In addition, the detection mechanism of MOFs and its structural dependent properties are also illustrated.

Advances in Rechargeable Batteries and Supercapacitors Based on Metal-Organic Frameworks

An analysis of the contribution that metal-organic frameworks (MOFs) have made to the development of energy storage devices over the past two decades such as rechargeable batteries and supercapacitors is presented here. This chapter reviews the different versions of electrode manufacturing based on metal-organic frameworks to be used in the design and manufacture of rechargeable batteries and supercapacitors. The MOFs examined in this chapter include those based on MOF-derived materials, MOF-based composites, and conductive MOFs. Despite the significant progress that has been achieved so far, many tasks must be made to reach total security so that performance parameters required for optimal performance of rechargeable batteries and supercapacitors in commercial, industrial, and military applications. Therefore, innovative conceptions of the actions that must be performed are explored in this chapter.

Remediation of Water and Wastewater Using Metal Organic Framework based Membranes

Over the past few years, metal-organic frameworks have gained considerable attention. Metal-organic frameworks are widely regarded as promising materials for separation, catalysis, molecular recognition, and storage applications. The applications and potentials of engineered forms of metal-organic frameworks such as thin films and membranes supported on various substrates in the area of water purification are discussed in this chapter. Metal-organic frameworks applications in separation and purification techniques with metal-organic frameworks-based membrane matrix is underlined at their promising levels. Metal-organic frameworks polymer composite membranes, including polymer-supported metal-organic frameworks membranes, are identified and the recent development are discussed. This chapter will provide a comprehensive assessment of recent studies on the removal of various contaminants from water using metal-organic frameworks-based membranes.

Metal-Organic Frameworks for Heavy Metal Removal From Water

Clean and safe drinking water is one of the most important and essential components on earth for human survival. However, due to the various anthropogenic activities, the surface and groundwater have been contaminated with heavy metals and radionuclides, and it has become a serious problem of concern globally. These non-biodegradable heavy metal ions from water tends to accumulate in the soil and living organisms and causes serious health hazards in humans. Thus, the finding of recyclable, water-stable MOFs, and multi-functional MOFs (hybrid MOFs) with superior adsorption capability have emerged as a novel material for the removal of heavy metal species (such as Cr(III)/Cr(VI), Cu(II), Hg(II), Cd(II), As(III)/As(V), Pb(II), radionuclides U(VI), Se(IV)/(VI), Cs(I) from aqueous solution. This chapter deals with the recent development of MOFs and their application in heavy metal removal from water.