Design, fabrication, luminescence and biomedical applications of UCNPs@mSiO2–ZnPc–CDs–P(NIPAm-MAA) nanocomposites

2016 ◽  
Vol 4 (35) ◽  
pp. 5883-5894 ◽  
Author(s):  
Jiating Xu ◽  
Dan Yang ◽  
Ruichan Lv ◽  
Bin Liu ◽  
Shili Gai ◽  
...  
Keyword(s):  
Multimodal Imaging ◽  
Biomedical Applications ◽  
Imaging Properties

The NaGdF4:Yb,Ce,Ho@NaGdF4@mSiO2–ZnPc–CDs–P(NIPAm-MAA)–DOX platform exhibits excellent anti-tumor efficacy due to synergistic PDT, PTT and chemotherapy, accompanied by multimodal imaging properties.

scholarly journals Multimodal Imaging Analysis Reveals Frontal-Associated Networks in Relation to Individual Resilience Strength

2021 ◽  
Vol 18 (3) ◽  
pp. 1123
Author(s):  
Shulan Hsieh ◽  
Zai-Fu Yao ◽  
Meng-Heng Yang
Keyword(s):  
Multimodal Imaging ◽  
Protective Factor ◽  
Multiple Regression Model ◽  
System Level ◽  
Psychological Resilience ◽  
Cognition And Emotion ◽  
Individual Resilience ◽  
Predictive Role ◽  
Imaging Properties

Psychological resilience is regarded as a critical protective factor for preventing the development of mental illness from experienced adverse events. Personal strength is one key element of resilience that reflects an individual’s reactions to negative life events and is crucial for successful adaptation. Previous studies have linked unimodal imaging measures with resilience. However, applying multimodal imaging measures could provide comprehensive organization information at the system level to examine whether an individual’s resilience strength is reflected in the brain’s structural and functional network. In this study, MRI was used to acquire multimodal imaging properties and subscales of personal strength in terms of resilience from 109 participants (48 females and 61 males). We employed a method of fusion independent component analysis to link the association between multimodal imaging components and personal strength of psychological resilience. The results reveal that a fusion component involving multimodal frontal networks in connecting with the parietal, occipital, and temporal regions is associated with the resilience score for personal strength. A multiple regression model further explains the predictive role of frontal-associated regions that cover a visual-related network regulating cognition and emotion to discern the perceived adverse experience. Overall, this study suggests that frontal-associated regions are related to individual resilience strength.

scholarly journals Air-Filled Microbubbles Based on Albumin Functionalized with Gold Nanocages and Zinc Phthalocyanine for Multimodal Imaging

Micromachines ◽  
2021 ◽  
Vol 12 (10) ◽  
pp. 1161
Author(s):  
Elizaveta A. Maksimova ◽  
Roman A. Barmin ◽  
Polina G. Rudakovskaya ◽  
Olga A. Sindeeva ◽  
Ekaterina S. Prikhozhdenko ◽  
...  
Keyword(s):  
Contrast Agents ◽  
Physicochemical Parameters ◽  
Multimodal Imaging ◽  
Biomedical Applications ◽  
Zinc Phthalocyanine ◽  
Fluorescence Tomography ◽  
Raster Scanning ◽  
Air Core ◽  
Gold Nanocages ◽  
Potential Use

Microbubbles are intravascular contrast agents clinically used in diagnostic sonography, echocardiography, and radiology imaging applications. However, up to date, the idea of creating microbubbles with multiple functionalities (e.g., multimodal imaging, photodynamic therapy) remained a challenge. One possible solution is the modification of bubble shells by introducing specific compounds responsible for such functions. In the present work, air-core microbubbles with the shell consisting of bovine serum albumin, albumin-coated gold nanocages, and zinc phthalocyanine were prepared using the sonication method. Various physicochemical parameters such as stability over time, size, and concentration were investigated to prove the potential use of these microbubbles as contrast agents. This work shows that hybrid microbubbles have all the necessary properties for multimodal imaging (ultrasound, raster-scanning microscopy, and fluorescence tomography), which demonstrate superior characteristics for potential theranostic and related biomedical applications.

scholarly journals Polysaccharide-Coated Magnetic Nanoparticles for Imaging and Gene Therapy

2015 ◽  
Vol 2015 ◽  
pp. 1-14 ◽  
Author(s):  
Saji Uthaman ◽  
Sang Joon Lee ◽  
Kondareddy Cherukula ◽  
Chong-Su Cho ◽  
In-Kyu Park
Keyword(s):  
Magnetic Nanoparticles ◽  
Biomedical Applications ◽  
Magnetic Particles ◽  
Metal Oxide Nanoparticles ◽  
Vital Role ◽  
Imaging Characteristics ◽  
Magnetic Metal ◽  
Therapeutic Properties ◽  
The Many ◽  
Imaging Properties

Today, nanotechnology plays a vital role in biomedical applications, especially for the diagnosis and treatment of various diseases. Among the many different types of fabricated nanoparticles, magnetic metal oxide nanoparticles stand out as unique and useful tools for biomedical applications, because of their imaging characteristics and therapeutic properties such as drug and gene carriers. Polymer-coated magnetic particles are currently of particular interest to investigators in the fields of nanobiomedicine and fundamental biomaterials. Theranostic magnetic nanoparticles that are encapsulated or coated with polymers not only exhibit imaging properties in response to stimuli, but also can efficiently deliver various drugs and therapeutic genes. Even though a large number of polymer-coated magnetic nanoparticles have been fabricated over the last decade, most of these have only been used for imaging purposes. The focus of this review is on polysaccharide-coated magnetic nanoparticles used for imaging and gene delivery.

Programmable illumination smartphone microscopy (PISM): A multimodal imaging platform for biomedical applications

2022 ◽  
Vol 151 ◽  
pp. 106931
Author(s):  
Diganta Rabha ◽  
Muzamil Ahmad Rather ◽  
Manabendra Mandal ◽  
Pabitra Nath
Keyword(s):  
Multimodal Imaging ◽  
Biomedical Applications

Multimodal imaging: modelling and segmentation with biomedical applications

2012 ◽  
Vol 6 (6) ◽  
pp. 524-539 ◽  
Author(s):  
A.M. Ali ◽  
N. Alajlan ◽  
A.A. Farag ◽  
A.A. Farag
Keyword(s):  
Multimodal Imaging ◽  
Biomedical Applications

scholarly journals Advanced Nanomaterials in Multimodal Imaging: Design, Functionalization, and Biomedical Applications

2010 ◽  
Vol 2010 ◽  
pp. 1-15 ◽  
Author(s):  
Zhe Liu ◽  
Fabian Kiessling ◽  
Jessica Gätjens
Keyword(s):  
Drug Delivery ◽  
Molecular Imaging ◽  
Contrast Agents ◽  
Multimodal Imaging ◽  
Biomedical Applications ◽  
State Of The Art ◽  
The Past ◽  
Recent Advances ◽  
Imaging Probes ◽  
New Generation

The biomedical applications of nanoparticles in molecular imaging, drug delivery, and therapy give rise to the term “nanomedicine” and have led to ever-growing developments in the past decades. New generation of imaging probes (or contrast agents) and state of the art of various strategies for efficient multimodal molecular imaging have drawn much attention and led to successful preclinical uses. In this context, we intend to elucidate the fundamentals and review recent advances as well as to provide an outlook perspective in these fields.

scholarly journals Magnetite-Arginine Nanoparticles as a Multifunctional Biomedical Tool

Nanomaterials ◽  
2020 ◽  
Vol 10 (10) ◽  
pp. 2014
Author(s):  
Victoria E. Reichel ◽  
Jasmin Matuszak ◽  
Klaas Bente ◽  
Tobias Heil ◽  
Alexander Kraupner ◽  
...  
Keyword(s):  
Biomedical Applications ◽  
Magnetic Particle ◽  
Hybrid Nanoparticles ◽  
Resonance Imaging ◽  
Magnetic Particle Imaging ◽  
Low Cytotoxicity ◽  
Diagnostic Applications ◽  
Theranostic Applications ◽  
Particle Imaging ◽  
Imaging Properties

Iron oxide nanoparticles are a promising platform for biomedical applications, both in terms of diagnostics and therapeutics. In addition, arginine-rich polypeptides are known to penetrate across cell membranes. Here, we thus introduce a system based on magnetite nanoparticles and the polypeptide poly-l-arginine (polyR-Fe3O4). We show that the hybrid nanoparticles exhibit a low cytotoxicity that is comparable to Resovist®, a commercially available drug. PolyR-Fe3O4 particles perform very well in diagnostic applications, such as magnetic particle imaging (1.7 and 1.35 higher signal respectively for the 3rd and 11th harmonic when compared to Resovist®), or as contrast agents for magnetic resonance imaging (R2/R1 ratio of 17 as compared to 11 at 0.94 T for Resovist®). Moreover, these novel particles can also be used for therapeutic purposes such as hyperthermia, achieving a specific heating power ratio of 208 W/g as compared to 83 W/g for Feridex®, another commercially available product. Therefore, we envision such materials to play a role in the future theranostic applications, where the arginine ability to deliver cargo into the cell can be coupled to the magnetite imaging properties and cancer fighting activity.

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