scholarly journals Advanced Nanomaterials in Multimodal Imaging: Design, Functionalization, and Biomedical Applications

2010 ◽  
Vol 2010 ◽  
pp. 1-15 ◽  
Author(s):  
Zhe Liu ◽  
Fabian Kiessling ◽  
Jessica Gätjens
Keyword(s):  
Drug Delivery ◽  
Molecular Imaging ◽  
Contrast Agents ◽  
Multimodal Imaging ◽  
Biomedical Applications ◽  
State Of The Art ◽  
The Past ◽  
Recent Advances ◽  
Imaging Probes ◽  
New Generation

The biomedical applications of nanoparticles in molecular imaging, drug delivery, and therapy give rise to the term “nanomedicine” and have led to ever-growing developments in the past decades. New generation of imaging probes (or contrast agents) and state of the art of various strategies for efficient multimodal molecular imaging have drawn much attention and led to successful preclinical uses. In this context, we intend to elucidate the fundamentals and review recent advances as well as to provide an outlook perspective in these fields.

Silicon Quantum Dots: Promising Theranostic Probes for the Future

2019 ◽  
Vol 20 (12) ◽  
pp. 1255-1263 ◽  
Author(s):  
Vishnu Sankar Sivasankarapillai ◽  
Jobin Jose ◽  
Muhammad Salman Shanavas ◽  
Akash Marathakam ◽  
Md. Sahab Uddin ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Quantum Dots ◽  
Optical Properties ◽  
Biomedical Applications ◽  
Medical Diagnostics ◽  
Silicon Quantum Dots ◽  
The Past ◽  
Research Areas ◽  
Semiconductor Crystals ◽  
New Generation

Nanotechnology has emerged as one of the leading research areas involving nanoscale manipulation of atoms and molecules. During the past decade, the growth of nanotechnology has been one of the most important developments that have taken place in the biomedical field. The new generation nanomaterials like Quantum dots are gaining much importance. Also, there is a growing interest in the development of nano-theranostics platforms in medical diagnostics, biomedical imaging, drug delivery, etc. Quantum dots are also known as nanoscale semiconductor crystals, with unique electronic and optical properties. Recently, silicon quantum dots are being studied extensively due to their less-toxic, inert nature and ease of surface modification. The silicon quantum dots (2-10nm) are comparatively stable, having optical properties of silicon nanocrystals. This review focuses on silicon quantum dots and their various biomedical applications like drug delivery regenerative medicine and tissue engineering. Also, the processes involved in their modification for various biomedical applications along with future aspects are discussed.

scholarly journals Recent development of nanoparticles for molecular imaging

2017 ◽  
Vol 375 (2107) ◽  
pp. 20170022 ◽  
Author(s):  
Jonghoon Kim ◽  
Nohyun Lee ◽  
Taeghwan Hyeon
Keyword(s):  
Surface Modification ◽  
Molecular Imaging ◽  
Contrast Agents ◽  
Multimodal Imaging ◽  
High Sensitivity ◽  
Accurate Diagnosis ◽  
Biological Processes ◽  
Future Perspectives ◽  
Cellular Functions ◽  
Diagnosis Of Diseases

Molecular imaging enables us to non-invasively visualize cellular functions and biological processes in living subjects, allowing accurate diagnosis of diseases at early stages. For successful molecular imaging, a suitable contrast agent with high sensitivity is required. To date, various nanoparticles have been developed as contrast agents for medical imaging modalities. In comparison with conventional probes, nanoparticles offer several advantages, including controllable physical properties, facile surface modification and long circulation time. In addition, they can be integrated with various combinations for multimodal imaging and therapy. In this opinion piece, we highlight recent advances and future perspectives of nanomaterials for molecular imaging. This article is part of the themed issue ‘Challenges for chemistry in molecular imaging’.

Gold nanoparticle (AuNP)-based drug delivery and molecular imaging for biomedical applications

2013 ◽  
Vol 37 (1) ◽  
pp. 53-59 ◽  
Author(s):  
Eun Hye Jeong ◽  
Giyoung Jung ◽  
Cheol Am Hong ◽  
Hyukjin Lee
Keyword(s):  
Drug Delivery ◽  
Molecular Imaging ◽  
Gold Nanoparticle ◽  
Biomedical Applications

scholarly journals Stimuli-responsive nanobubbles for biomedical applications

2021 ◽  
Author(s):  
Ranhua Xiong ◽  
Ronald X. Xu ◽  
Chaobo Huang ◽  
Stefaan De Smedt ◽  
Kevin Braeckmans
Keyword(s):  
Drug Delivery ◽  
Biomedical Applications ◽  
Stimuli Responsive ◽  
Recent Advances ◽  
Tumor Tissues ◽  
Bio Imaging

This review presents an overview of the recent advances in the development of stimuli-responsive nanobubbles and their novel biomedical applications including bio-imaging, drug delivery and ablation of tumor tissues.

Recent advances in the design of inorganic and nano-clay particles for the treatment of brain disorders

2021 ◽  
Author(s):  
Francesca Persano ◽  
Svetlana Batasheva ◽  
Gölnur Fakhrullina ◽  
Giuseppe Gigli ◽  
Stefano Leporatti ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Silica Nanoparticles ◽  
Biomedical Applications ◽  
Inorganic Materials ◽  
Brain Disorders ◽  
Clay Particles ◽  
Recent Advances ◽  
Wide Range ◽  
Nano Clay

Inorganic materials, in particular nanoclays and silica nanoparticles, have attracted enormous attention due to their versatile and tuneable properties, making them ideal candidates for a wide range of biomedical applications, such as drug delivery.

scholarly journals Recent Advances in Zwitterionic Hydrogels: Preparation, Property, and Biomedical Application

Gels ◽  
2022 ◽  
Vol 8 (1) ◽  
pp. 46
Author(s):  
Sihang Liu ◽  
Jingyi Tang ◽  
Fangqin Ji ◽  
Weifeng Lin ◽  
Shengfu Chen
Keyword(s):  
Immune System ◽  
Polyethylene Glycol ◽  
Biomedical Applications ◽  
Biomedical Application ◽  
Synthetic Polymers ◽  
Human Environment ◽  
The Past ◽  
Recent Advances ◽  
Nonspecific Protein Adsorption ◽  
Anionic Groups

Nonspecific protein adsorption impedes the sustainability of materials in biologically related applications. Such adsorption activates the immune system by quick identification of allogeneic materials and triggers a rejection, resulting in the rapid failure of implant materials and drugs. Antifouling materials have been rapidly developed in the past 20 years, from natural polysaccharides (such as dextran) to synthetic polymers (such as polyethylene glycol, PEG). However, recent studies have shown that traditional antifouling materials, including PEG, still fail to overcome the challenges of a complex human environment. Zwitterionic materials are a class of materials that contain both cationic and anionic groups, with their overall charge being neutral. Compared with PEG materials, zwitterionic materials have much stronger hydration, which is considered the most important factor for antifouling. Among zwitterionic materials, zwitterionic hydrogels have excellent structural stability and controllable regulation capabilities for various biomedical scenarios. Here, we first describe the mechanism and structure of zwitterionic materials. Following the preparation and property of zwitterionic hydrogels, recent advances in zwitterionic hydrogels in various biomedical applications are reviewed.

scholarly journals Air-Filled Microbubbles Based on Albumin Functionalized with Gold Nanocages and Zinc Phthalocyanine for Multimodal Imaging

Micromachines ◽  
2021 ◽  
Vol 12 (10) ◽  
pp. 1161
Author(s):  
Elizaveta A. Maksimova ◽  
Roman A. Barmin ◽  
Polina G. Rudakovskaya ◽  
Olga A. Sindeeva ◽  
Ekaterina S. Prikhozhdenko ◽  
...  
Keyword(s):  
Contrast Agents ◽  
Physicochemical Parameters ◽  
Multimodal Imaging ◽  
Biomedical Applications ◽  
Zinc Phthalocyanine ◽  
Fluorescence Tomography ◽  
Raster Scanning ◽  
Air Core ◽  
Gold Nanocages ◽  
Potential Use

Microbubbles are intravascular contrast agents clinically used in diagnostic sonography, echocardiography, and radiology imaging applications. However, up to date, the idea of creating microbubbles with multiple functionalities (e.g., multimodal imaging, photodynamic therapy) remained a challenge. One possible solution is the modification of bubble shells by introducing specific compounds responsible for such functions. In the present work, air-core microbubbles with the shell consisting of bovine serum albumin, albumin-coated gold nanocages, and zinc phthalocyanine were prepared using the sonication method. Various physicochemical parameters such as stability over time, size, and concentration were investigated to prove the potential use of these microbubbles as contrast agents. This work shows that hybrid microbubbles have all the necessary properties for multimodal imaging (ultrasound, raster-scanning microscopy, and fluorescence tomography), which demonstrate superior characteristics for potential theranostic and related biomedical applications.

scholarly journals Phenylboronic acid-decorated polymeric nanomaterials for advanced bio-application

2019 ◽  
Vol 8 (1) ◽  
pp. 548-561
Author(s):  
Tianyu Lan ◽  
Qianqian Guo
Keyword(s):  
Drug Delivery ◽  
Sialic Acid ◽  
Drug Delivery Systems ◽  
Phenylboronic Acid ◽  
Delivery Systems ◽  
Therapeutic Applications ◽  
The Past ◽  
Recent Advances

Abstract The paradigm of using phenylboronic acid-decorated polymeric nanomaterials for advanced bio-application has been well established over the past decade. Phenylboronic acid and its derivatives are known to form reversible complexes with polyols, including sugar, diol and diphenol. This unique chemistry of phenylboronic acid has given many chances to be exploited for diagnostic and therapeutic applications. This review highlights the recent advances in fabrication of phenylboronic acid-decorated polymeric nanomaterials, especially focus on the interactions with glucose and sialic acid. Applications of these phenylboronic acid-decorated nanomaterials in drug delivery systems and biosensors are discussed.

scholarly journals Stimuli-Responsive Polypeptides for Biomedical Applications

Polymers ◽  
2018 ◽  
Vol 10 (8) ◽  
pp. 830 ◽  
Author(s):  
DaeYong Lee ◽  
N. Rejinold ◽  
Seong Jeong ◽  
Yeu-Chun Kim
Keyword(s):  
Physical Properties ◽  
Adenosine Triphosphate ◽  
Biomedical Applications ◽  
Stimuli Responsive ◽  
The Past ◽  
Bioactive Properties ◽  
Recent Advances ◽  
Ph Reduction ◽  
Biomedical Fields

Stimuli-responsive polypeptides have gained attention because desirable bioactive properties can be easily imparted to them while keeping their biocompatibility and biodegradability intact. In this review, we summarize the most recent advances in various stimuli-responsive polypeptides (pH, reduction, oxidation, glucose, adenosine triphosphate (ATP), and enzyme) over the past five years. Various synthetic strategies exploited for advanced polypeptide-based materials are introduced, and their applicability in biomedical fields is discussed. The recent polypeptides imparted with new stimuli-responsiveness and their novel chemical and physical properties are explained in this review.

Recent Advances of Gold Nanoparticles in Biomedical Applications: State of the Art

2018 ◽  
Vol 77 (2) ◽  
pp. 123-137 ◽  
Author(s):  
Negar Sedghi Aminabad ◽  
Masoud Farshbaf ◽  
Abolfazl Akbarzadeh
Keyword(s):  
Gold Nanoparticles ◽  
Biomedical Applications ◽  
State Of The Art ◽  
Recent Advances
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