Understanding how cAMP-dependent protein kinase can catalyze phosphoryl transfer in the presence of Ca2+and Sr2+: a QM/MM study

2017 ◽  
Vol 19 (16) ◽  
pp. 10377-10394 ◽  
Author(s):  
Ayax Pérez-Gallegos ◽  
Mireia Garcia-Viloca ◽  
Àngels González-Lafont ◽  
José M. Lluch

Theoretical results demonstrate for the first time at the molecular level that the overall PKAc-catalyzed phosphoryl-transfer reaction is plausible with Ca2+and Sr2+, alkaline earth metal ions other than Mg2+, which is in good agreement with experiments.

2011 ◽  
Vol 50 (15) ◽  
pp. 6956-6964 ◽  
Author(s):  
Wen-Jian Chen ◽  
Da-Hai Yu ◽  
Xin Xiao ◽  
Yun-Qian Zhang ◽  
Qian-Jiang Zhu ◽  
...  

Author(s):  
Yiran Wang ◽  
Wen Zhang ◽  
Xianjie Zeng ◽  
Tao Deng ◽  
Jianyou Wang

1947 ◽  
Vol 20 (3) ◽  
pp. 769-774
Author(s):  
G. Austerweil

Abstract Before taking up the actual subject of the present work, it is well to point out what is meant by an exchange of ions and to define an ion exchanger. An exchange of ions is a chemical reaction which takes place in a heterogeneous medium; when a solid heteropolar substance is immersed in a liquid, usually aqueous, ions belonging to the solid pass into the liquid in exchange for ions of the same polarity in solution in the liquid, and these dissolved ions thereby become fixed on the solid substance in place of the ions which the latter has just given up. As an example, minerals of the type of zeolite (green sand, harmatome, chabasie, etc.) can exchange their alkaline-earth metal ions, i.e., their cations, for sodium ions in an aqueous solution of sea salt which wets them or penetrates through them, and this phenomenon is reversible. Such a reaction is the basis of the detartarizing purification of industrial waters containing lime. Likewise the heteropolarity of exchangers sometimes renders their anions mobile, i.e., some substances give up their anions to liquids which wet them in exhange for the anions of these liquids, which thereby replace the anions liberated from the solids.


2011 ◽  
Vol 3 (1) ◽  
Author(s):  
Nelly Mateeva ◽  
Shihab Deiab ◽  
Edikan Archibong ◽  
Donka Tasheva ◽  
Bereket Mochona ◽  
...  

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