Long non-coding RNA SNHG17 is an unfavourable prognostic factor and promotes cell proliferation by epigenetically silencing P57 in colorectal cancer

2017 ◽  
Vol 13 (11) ◽  
pp. 2350-2361 ◽  
Author(s):  
Zhonghua Ma ◽  
Shengying Gu ◽  
Min Song ◽  
Changsheng Yan ◽  
Bingqing Hui ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cell Proliferation ◽  
Prognostic Factor ◽  
First Report ◽  
Non Coding Rna ◽  
Long Non Coding Rna ◽  
Unfavourable Prognostic Factor

The first report of potential mechanisms of IncRNA SNHG17 in CRC, prompting the development of IncRNA-directed diagnosis and treatments.

scholarly journals Correction: Long non-coding RNA SNHG17 is an unfavourable prognostic factor and promotes cell proliferation by epigenetically silencing P57 in colorectal cancer

2020 ◽  
Vol 16 (2) ◽  
pp. 174-175
Author(s):  
Zhonghua Ma ◽  
Shengying Gu ◽  
Min Song ◽  
Changsheng Yan ◽  
Bingqing Hui ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cell Proliferation ◽  
Prognostic Factor ◽  
Non Coding Rna ◽  
Long Non Coding Rna ◽  
Unfavourable Prognostic Factor

Correction for ‘Long non-coding RNA SNHG17 is an unfavourable prognostic factor and promotes cell proliferation by epigenetically silencing P57 in colorectal cancer’ by Zhonghua Ma et al., Mol. BioSyst., 2017, 13, 2350–2361.

scholarly journals Long non-coding RNA FOXP4-AS1 is an unfavourable prognostic factor and regulates proliferation and apoptosis in colorectal cancer

2016 ◽  
Vol 50 (1) ◽  
pp. e12312 ◽  
Author(s):  
Juan Li ◽  
Yifan Lian ◽  
Changsheng Yan ◽  
Zeling Cai ◽  
Jie Ding ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Prognostic Factor ◽  
Non Coding Rna ◽  
Proliferation And Apoptosis ◽  
Long Non Coding Rna ◽  
Unfavourable Prognostic Factor

Long non-coding RNA RUNX1-IT1 plays a tumour-suppressive role in colorectal cancer by inhibiting cell proliferation and migration

2018 ◽  
Vol 37 (1) ◽  
pp. 11-20 ◽  
Author(s):  
Jinxin Shi ◽  
Xi Zhong ◽  
Yongxi Song ◽  
Zhonghua Wu ◽  
Peng Gao ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cell Proliferation ◽  
Cell Proliferation And Migration ◽  
Non Coding Rna ◽  
And Migration ◽  
Long Non Coding Rna ◽  
Proliferation And Migration

scholarly journals Long Non-Coding RNA Reprogramming (ROR) Promotes Cell Proliferation in Colorectal Cancer via Affecting P53

2017 ◽  
Vol 23 ◽  
pp. 919-928 ◽  
Author(s):  
Hong Li ◽  
Xiumei Jiang ◽  
Xuemei Niu
Keyword(s):  
Colorectal Cancer ◽  
Cell Proliferation ◽  
Non Coding Rna ◽  
Long Non Coding Rna

Long non-coding RNA Linc00675 suppresses cell proliferation and metastasis in colorectal cancer via acting on miR-942 and Wnt/β-catenin signaling

2018 ◽  
Vol 101 ◽  
pp. 769-776 ◽  
Author(s):  
Zhiming Shan ◽  
Na An ◽  
Jielin Qin ◽  
Junmei Yang ◽  
Hongqi Sun ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cell Proliferation ◽  
Non Coding Rna ◽  
Proliferation And Metastasis ◽  
Long Non Coding Rna ◽  
Cell Proliferation And Metastasis

scholarly journals HOTAIR long non-coding RNA is a negative prognostic factor not only in primary tumors, but also in the blood of colorectal cancer patients

2014 ◽  
Vol 35 (7) ◽  
pp. 1510-1515 ◽  
Author(s):  
M. Svoboda ◽  
J. Slyskova ◽  
M. Schneiderova ◽  
P. Makovicky ◽  
L. Bielik ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Prognostic Factor ◽  
Cancer Patients ◽  
Primary Tumors ◽  
Non Coding Rna ◽  
Negative Prognostic Factor ◽  
Colorectal Cancer Patients ◽  
Long Non Coding Rna

scholarly journals The Long Non-Coding RNA CRNDE Promotes Colorectal Carcinoma Progression by Competitively Binding miR-217 with TCF7L2 and Enhancing the Wnt/β-Catenin Signaling Pathway

2017 ◽  
Vol 41 (6) ◽  
pp. 2489-2502 ◽  
Author(s):  
Bo Yu ◽  
Xuan Ye ◽  
Qiong Du ◽  
Bin Zhu ◽  
Qing Zhai
Keyword(s):  
Colorectal Cancer ◽  
Cell Proliferation ◽  
Signaling Pathway ◽  
Western Blotting ◽  
Migration And Invasion ◽  
Down Regulation ◽  
Over Expression ◽  
Non Coding Rna ◽  
Colorectal Cancer Cells ◽  
Long Non Coding Rna

Background/Aims: The long non-coding RNA colorectal neoplasia differentially expressed (CRNDE) contributes to the proliferation and migration of tumors. However, its molecular mechanism underlying gastric cancer remains unknown. In the present study, we investigated whether CRNDE was involved in the development of colorectal cancer via the binding of microRNA (miR)-217 with transcription factor 7-like 2 (TCF7L2) to enhance the Wnt signaling pathway. Methods: Quantitative polymerase chain reaction was used to detect CRNDE, miR-217 and TCF7L2 in colorectal cancer tissues and cells. The CCK-8 assay, wound healing assay, and Transwell assay were used to detect cell proliferation, migration and invasion, respectively. Western blotting and luciferase activity assays were used to identify CRNDE and TCF7L2 as one of the direct targets of miR-217. The activity of the Wnt/β-catenin signaling pathway was analyzed by the TOPflash assay, and the subcellular localization of β-catenin and TCF7L2 was analyzed by western blotting and confocal microscopy. Results: In this study, we found that high expression of CRNDE is negatively correlated with low expression of miR-217 in colorectal cancer tissue and colorectal cancer cells. The dual luciferase reporter analysis showed that miR-217 is bound to CRNDE and TCF7L2 and negatively regulate their expression. CRNDE down-regulation inhibited the cell proliferation, migration and invasion in vitro and in vivo and the inhibitions were both completely blocked after miR-217 inhibition or TCF7L2 overexpression. Finally, TOPflash analysis showed that the activity of Wnt/β-catenin signaling is inhibited by CRNDE down-regulation and rescued by TCF7L2 over-expression. Consistently immunostaining and western blotting analysis showed that the expression of b-catenin and TCF7L2 in the nucleus was significantly decreased by CRNDE down-regulation and was rescued by TCF7L2 over-expression. Conclusions: The present study suggest that CRNDE involves in the cell proliferation, migration and invasion of colorectal cancer cells via increasing the expression of TCF7L2 and activity of Wnt/β-catenin signaling through binding miR-217 competitively.

scholarly journals Overexpression of the long non-coding RNA BLACAT1 promotes cell proliferation and invasion in colorectal cancer

2019 ◽  
Vol 8 (1) ◽  
pp. 35-43
Author(s):  
Chiwen Bu ◽  
Biao Wang ◽  
Dong Zhang ◽  
Zeqing Mao ◽  
Chibin Pu
Keyword(s):  
Colorectal Cancer ◽  
Cell Proliferation ◽  
Non Coding Rna ◽  
Long Non Coding Rna ◽  
Proliferation And Invasion
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