“Click” functionalization of dual stimuli-responsive polymer nanocapsules for drug delivery systems

2017 ◽  
Vol 8 (20) ◽  
pp. 3056-3065 ◽  
Author(s):  
Wen Jing Yang ◽  
Tingting Zhao ◽  
Peng Zhou ◽  
Simou Chen ◽  
Yu Gao ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Click Chemistry ◽  
Surface Functionalization ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Stimuli Responsive ◽  
Responsive Polymer ◽  
Stimuli Responsive Polymer

“Clickable” and dual stimuli-responsive nanocapsules were developed for facile surface functionalizationviathiol–yne click chemistry and employed as drug nano-carriers.

Advanced Hydrogels Based Drug Delivery Systems for Ophthalmic Delivery

2020 ◽  
Vol 13 (4) ◽  
pp. 291-300 ◽  
Author(s):  
Srividya Gorantla ◽  
Tejashree Waghule ◽  
Vamshi Krishna Rapalli ◽  
Prem Prakash Singh ◽  
Sunil Kumar Dubey ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Age Related Macular Degeneration ◽  
Stimuli Responsive ◽  
Duration Of Action ◽  
Age Related ◽  
Aqueous Gels ◽  
Ophthalmic Delivery ◽  
3D Printed

Hydrogels are aqueous gels composed of cross-linked networks of hydrophilic polymers. Stimuli-responsive based hydrogels have gained focus over the past 20 years for treating ophthalmic diseases. Different stimuli-responsive mechanisms are involved in forming polymer hydrogel networks, including change in temperature, pH, ions, and others including light, thrombin, pressure, antigen, and glucose-responsive. Incorporation of nanocarriers with these smart stimuli-responsive drug delivery systems that can extend the duration of action by increasing ocular bioavailability and reducing the dosing frequency. This review will focus on the hydrogel drug delivery systems highlighting the gelling mechanisms and emerging stimuli-responsive hydrogels from preformed gels, nanogels, and the role of advanced 3D printed hydrogels in vision-threatening diseases like age-related macular degeneration and retinitis pigmentosa. It also provides insight into the limitations of hydrogels along with the safety and biocompatibility of the hydrogel drug delivery systems.

scholarly journals Polymer-Based Smart Drug Delivery Systems for Skin Application and Demonstration of Stimuli-Responsiveness

Polymers ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 1285
Author(s):  
Louise Van Gheluwe ◽  
Igor Chourpa ◽  
Coline Gaigne ◽  
Emilie Munnier
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Ex Vivo ◽  
Delivery Systems ◽  
Stimuli Responsive ◽  
Stimuli Responsive Polymers ◽  
Smart Drug ◽  
Smart Drug Delivery

Progress in recent years in the field of stimuli-responsive polymers, whose properties change depending on the intensity of a signal, permitted an increase in smart drug delivery systems (SDDS). SDDS have attracted the attention of the scientific community because they can help meet two current challenges of the pharmaceutical industry: targeted drug delivery and personalized medicine. Controlled release of the active ingredient can be achieved through various stimuli, among which are temperature, pH, redox potential or even enzymes. SDDS, hitherto explored mainly in oncology, are now developed in the fields of dermatology and cosmetics. They are mostly hydrogels or nanosystems, and the most-used stimuli are pH and temperature. This review offers an overview of polymer-based SDDS developed to trigger the release of active ingredients intended to treat skin conditions or pathologies. The methods used to attest to stimuli-responsiveness in vitro, ex vivo and in vivo are discussed.

Facile, Template-Free Synthesis of Stimuli-Responsive Polymer Nanocapsules for Targeted Drug Delivery

2010 ◽  
Vol 122 (26) ◽  
pp. 4507-4510 ◽  
Author(s):  
Eunju Kim ◽  
Dongwoo Kim ◽  
Hyuntae Jung ◽  
Jiyeong Lee ◽  
Somak Paul ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Targeted Drug Delivery ◽  
Stimuli Responsive ◽  
Responsive Polymer ◽  
Template Free ◽  
Targeted Drug ◽  
Stimuli Responsive Polymer

Innentitelbild: Facile, Template-Free Synthesis of Stimuli-Responsive Polymer Nanocapsules for Targeted Drug Delivery (Angew. Chem. 26/2010)

2010 ◽  
Vol 122 (26) ◽  
pp. 4412-4412
Author(s):  
Eunju Kim ◽  
Dongwoo Kim ◽  
Hyuntae Jung ◽  
Jiyeong Lee ◽  
Somak Paul ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Targeted Drug Delivery ◽  
Stimuli Responsive ◽  
Responsive Polymer ◽  
Template Free ◽  
Targeted Drug ◽  
Stimuli Responsive Polymer

Collagen Nanoparticles in Drug Delivery Systems and Tissue Engineering

2021 ◽  
Vol 11 (23) ◽  
pp. 11369
Author(s):  
Ashni Arun ◽  
Pratyusha Malrautu ◽  
Anindita Laha ◽  
Hongrong Luo ◽  
Seeram Ramakrishna
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Drug Solubility ◽  
Stimuli Responsive ◽  
Preparation Methods ◽  
Nanoparticle Preparation ◽  
Responsive Behavior ◽  
Reduced Toxicity

The versatile natural polymer, collagen, has gained vast attention in biomedicine. Due to its biocompatibility, biodegradability, weak antigenicity, biomimetics and well-known safety profile, it is widely used as a drug, protein and gene carrier, and as a scaffold matrix in tissue engineering. Nanoparticles develop favorable chemical and physical properties such as increased drug half-life, improved hydrophobic drug solubility and controlled and targeted drug release. Their reduced toxicity, controllable characteristics of scaffolds and stimuli-responsive behavior make them suitable in regenerative medicine and tissue engineering. Collagen associates and absorbs nanoparticles leading to significant impacts on their biological functioning in any biofluid. This review will discuss collagen nanoparticle preparation methods and their applications and developments in drug delivery systems and tissue engineering.

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