scholarly journals A cancer cell-specific two-photon fluorescent probe for imaging hydrogen sulfide in living cells

RSC Advances ◽  
2017 ◽  
Vol 7 (26) ◽  
pp. 15817-15822 ◽  
Author(s):  
Xuezhen Song ◽  
Baoli Dong ◽  
Xiuqi Kong ◽  
Chao Wang ◽  
Nan Zhang ◽  
...  
Keyword(s):  
Hydrogen Sulfide ◽  
Tumor Growth ◽  
Cancer Cells ◽  
Fluorescent Probe ◽  
Cancer Cell ◽  
Close Relation ◽  
Living Cells ◽  
Dependent Manner ◽  
Concentration Dependent Manner ◽  
Two Photon

Hydrogen sulfide (H2S) could induce the proliferation of cancer cells in a concentration-dependent manner, and has close relation with the tumor growth.

A smart mitochondria-targeting TP-NIR fluorescent probe for selective and sensitive sensing H2S in living cells and mice

2021 ◽  
Author(s):  
Qiaomei Yang ◽  
Liyi Zhou ◽  
Longpeng Peng ◽  
Gangqiang Yuan ◽  
Haiyuan Ding ◽  
...  
Keyword(s):  
Hydrogen Sulfide ◽  
Fluorescent Probe ◽  
Near Infrared ◽  
Living Cells ◽  
Signal Molecules ◽  
Two Photon ◽  
Mitochondria Targeting

Hydrogen sulfide (H2S) is one of the important gaseous signal molecules and plays key roles in various biologically crucial processes. In this work, we report a novel two-photon near-infrared (TP-NIR)...

A two-photon fluorescent probe for imaging hydrogen sulfide in living cells

2013 ◽  
Vol 99 (3) ◽  
pp. 537-542 ◽  
Author(s):  
Tianyu Liu ◽  
Xinfu Zhang ◽  
Qinglong Qiao ◽  
Chunyan Zou ◽  
Lei Feng ◽  
...  
Keyword(s):  
Hydrogen Sulfide ◽  
Fluorescent Probe ◽  
Living Cells ◽  
Two Photon

A tumor-targeting and lysosome-specific two-photon fluorescent probe for imaging pH changes in living cells

2017 ◽  
Vol 5 (5) ◽  
pp. 988-995 ◽  
Author(s):  
Baoli Dong ◽  
Xuezhen Song ◽  
Xiuqi Kong ◽  
Chao Wang ◽  
Nan Zhang ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Fluorescent Probe ◽  
Tumor Targeting ◽  
Living Cells ◽  
Lysosomal Ph ◽  
Ph Changes ◽  
Two Photon

Lysosomal pH is closely related to the metastasis and apoptosis of cancer cells.

scholarly journals Taxifolin Resensitizes Multidrug Resistance Cancer Cells via Uncompetitive Inhibition of P-Glycoprotein Function

Molecules ◽  
2018 ◽  
Vol 23 (12) ◽  
pp. 3055 ◽  
Author(s):  
Hsiu-Ju Chen ◽  
Yun-Lung Chung ◽  
Chia-Ying Li ◽  
Ying-Tzu Chang ◽  
Charles Wang ◽  
...  
Keyword(s):  
Multidrug Resistance ◽  
Cancer Cells ◽  
Cell Line ◽  
Cancer Cell ◽  
Cancer Cell Line ◽  
Chemotherapeutic Agents ◽  
Dependent Manner ◽  
Concentration Dependent Manner ◽  
Uncompetitive Inhibition ◽  
P Glycoprotein

P-glycoprotein (P-gp) effluxes lots of chemotherapeutic agents and leads to multidrug resistance (MDR) in cancer treatments. The development of P-gp inhibitors from natural products provide a potential strategy for the beneficial clinical outcomes. This study aimed to evaluate the effects of the natural flavonoid taxifolin, luteolin, (−)-gallocatechin, and (−)-catechin on human P-gp activity. The kinetic interactions and underlying mechanisms of taxifolin-mediated transporter inhibition were further investigated. The transporter inhibition ability was evaluated in human P-gp stable expression cells (ABCB1/Flp-InTM-293) by calcein-AM uptake assays. The kinetics study for P-gp inhibition was evaluated by doxorubicin and rhodamine123 efflux assays. The MDR reversal ability of taxifolin were performed by SRB assays to detect the cell viability in sensitive cancer cell line (HeLaS3), and resistant cancer cell line (KB-vin). Cell cycle analysis and ABCB1 real-time RT-PCR were used for mechanical exploration. The results demonstrated that taxifolin decreased ABCB1 expression in a concentration-dependent manner. The function of P-gp was inhibited by taxifolin through uncompetitive inhibition of rhodamine 123 and doxorubicin efflux. The combination of taxifolin significantly resensitized MDR cancer cells to chemotherapeutic agents. These results suggested that taxifolin may be considered as a potential P-gp modulator for synergistic treatment of MDR cancers.

A new strategy to improve the water solubility of an organic fluorescent probe using silicon nanodots and fabricate two-photon SiND-ANPA-N3 for visualizing hydrogen sulfide in living cells and onion tissues

2020 ◽  
Vol 8 (7) ◽  
pp. 1422-1431 ◽  
Author(s):  
Yu-Jia Fu ◽  
San-San Shen ◽  
Xiao-Feng Guo ◽  
Hong Wang
Keyword(s):  
Hydrogen Sulfide ◽  
Fluorescent Probe ◽  
Water Solubility ◽  
Aqueous Media ◽  
Living Cells ◽  
Water Soluble ◽  
Two Photon ◽  
New Strategy

A water-soluble fluorescent probe based on SiNDs for H2S detection can be used in both fully aqueous media and living cells.

A mitochondrial-targeted two-photon fluorescent probe for imaging hydrogen sulfide in the living cells and mouse liver tissues

2017 ◽  
Vol 248 ◽  
pp. 50-56 ◽  
Author(s):  
Beibei Deng ◽  
Mingguang Ren ◽  
Jian-Yong Wang ◽  
Kai Zhou ◽  
Weiying Lin
Keyword(s):  
Hydrogen Sulfide ◽  
Fluorescent Probe ◽  
Mouse Liver ◽  
Living Cells ◽  
Two Photon ◽  
Liver Tissues

A dual-site two-photon fluorescent probe for visualizing lysosomes and tracking lysosomal hydrogen sulfide with two different sets of fluorescence signals in the living cells and mouse liver tissues

2016 ◽  
Vol 52 (43) ◽  
pp. 7016-7019 ◽  
Author(s):  
Yong Liu ◽  
Fangfang Meng ◽  
Longwei He ◽  
Keyin Liu ◽  
Weiying Lin
Keyword(s):  
Hydrogen Sulfide ◽  
Fluorescent Probe ◽  
Mouse Liver ◽  
Living Cells ◽  
Two Photon ◽  
Dual Site ◽  
Liver Tissues

We have firstly developed a fluorescent probe TP-PMVC, which can monitor lysosomes and lysosomal H2S with dual signal.

Sign in / Sign up

Export Citation Format

Share Document