NIR light-activated dual-modality cancer therapy mediated by photochemical internalization of porous nanocarriers with tethered lipid bilayers

Near-infrared (NIR) light induced photothermal cancer therapy using nanomaterials as photothermal agents has attracted considerable research interest over the past few years. As the key factor in the photothermal therapy...

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Photocontrolled apoptosis induction using precursor miR-664a and an RNA carrier-conjugated with photosensitizer

Scientific Reports ◽

10.1038/s41598-021-94249-7 ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Kazunori Watanabe ◽

Tomoko Nawachi ◽

Ruriko Okutani ◽

Takashi Ohtsuki

Keyword(s):

Cancer Therapy ◽

Cell Types ◽

Drug Candidate ◽

Apoptosis Induction ◽

Delivery Method ◽

Apoptotic Pathway ◽

Photochemical Internalization ◽

Therapeutic Uses ◽

Induction Of Apoptosis ◽

Nucleic Acid Drug

AbstractMethods to spatially induce apoptosis are useful for cancer therapy. To control the induction of apoptosis, methods using light, such as photochemical internalization (PCI), have been developed. We hypothesized that photoinduced delivery of microRNAs (miRNAs) that regulate apoptosis could spatially induce apoptosis. In this study, we identified pre-miR-664a as a novel apoptosis-inducing miRNA via mitochondrial apoptotic pathway. Further, we demonstrated the utility of photoinduced cytosolic dispersion of RNA (PCDR), which is an intracellular RNA delivery method based on PCI. Indeed, apoptosis is spatially regulated by pre-miR-664a and PCDR. In addition, we found that apoptosis induced by pre-miR-664a delivered by PCDR was more rapid than that by lipofection. These results suggest that pre-miR-664a is a nucleic acid drug candidate for cancer therapy and PCDR and pre-miR-664a-based strategies have potential therapeutic uses for diseases affecting various cell types.

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Biodegradable Nano-photosensitizer with Photoactivatable Singlet Oxygen Generation for Synergistic Phototherapy

Journal of Materials Chemistry B ◽

10.1039/d1tb00937k ◽

2021 ◽

Author(s):

Jiaxin Shen ◽

Dandan Chen ◽

Ye Liu ◽

Guoyang Gao ◽

Zhihe Liu ◽

...

Keyword(s):

Photodynamic Therapy ◽

Cancer Therapy ◽

Singlet Oxygen ◽

Near Infrared ◽

Promising Method ◽

Normal Cells ◽

Oxygen Generation ◽

Singlet Oxygen Generation ◽

Nir Light

Photodynamic therapy (PDT) is a promising method for cancer therapy and also may initiate unexpected damages to normal cells and tissues. Herein, we developed a near-infrared (NIR) light-activatable nanophotosensitizer, which...

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Engineered NIR light-responsive bacteria as anti-tumor agent for targeted and precise cancer therapy

Chemical Engineering Journal ◽

10.1016/j.cej.2021.130842 ◽

2021 ◽

pp. 130842

Author(s):

Huizhuo Pan ◽

Lianyue Li ◽

Gaoju Pang ◽

Chunli Han ◽

Baona Liu ◽

...

Keyword(s):

Cancer Therapy ◽

Nir Light ◽

Tumor Agent

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Novel concept of the smart NIR-light–controlled drug release of black phosphorus nanostructure for cancer therapy

Proceedings of the National Academy of Sciences ◽

10.1073/pnas.1714421115 ◽

2018 ◽

Vol 115 (3) ◽

pp. 501-506 ◽

Cited By ~ 356

Author(s):

Meng Qiu ◽

Dou Wang ◽

Weiyuan Liang ◽

Liping Liu ◽

Yin Zhang ◽

...

Keyword(s):

Drug Delivery ◽

Cancer Therapy ◽

Drug Release ◽

Drug Delivery System ◽

Delivery System ◽

Near Infrared ◽

Black Phosphorus ◽

Deep Penetration ◽

Nir Light

A biodegradable drug delivery system (DDS) is one the most promising therapeutic strategies for cancer therapy. Here, we propose a unique concept of light activation of black phosphorus (BP) at hydrogel nanostructures for cancer therapy. A photosensitizer converts light into heat that softens and melts drug-loaded hydrogel-based nanostructures. Drug release rates can be accurately controlled by light intensity, exposure duration, BP concentration, and hydrogel composition. Owing to sufficiently deep penetration of near-infrared (NIR) light through tissues, our BP-based system shows high therapeutic efficacy for treatment of s.c. cancers. Importantly, our drug delivery system is completely harmless and degradable in vivo. Together, our work proposes a unique concept for precision cancer therapy by external light excitation to release cancer drugs. If these findings are successfully translated into the clinic, millions of patients with cancer will benefit from our work.

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