ROS-responsive capsules engineered from green tea polyphenol–metal networks for anticancer drug delivery

The main aim of nonmaterials is optimization on site of action at tumors cells as well least toxicity by its formulation. Only to progress the biodistribution of neoplasia drugs, nanoparticles are designed for optimal size and surface individuality to expand their flow time within the blood circulation. They are also proficient to carry their laden active drugs to cancer cells by using the single functional changes of tumors, as like their improved permeability and preservation result and the tumor microenvironment. In this study report, we have discussed the current status of nanoparticles developed as targeting delivery systems for anticancer drugs. Keywords: Cancer, Drug Delivery, Nanomedicine, Chemotherapy, Liposome

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A new biosafe reactive oxygen species (ROS)-responsive nanoplatform for drug delivery

RSC Advances ◽

10.1039/c5ra25913d ◽

2016 ◽

Vol 6 (45) ◽

pp. 38984-38989 ◽

Cited By ~ 6

Author(s):

Qing Li ◽

Yong Wen ◽

Jie Wen ◽

Yun-Peng Zhang ◽

Xiao-Ding Xu ◽

...

Keyword(s):

Reactive Oxygen Species ◽

Drug Delivery ◽

Cancer Therapy ◽

Oral Cancer ◽

Cancer Cells ◽

Anticancer Drug ◽

Reactive Oxygen ◽

Oxygen Species ◽

Rapid Release ◽

Oral Cancer Cells

.A new ROS-responsive nanoplatform was deleveloped to load anticancer drug for oral cancer therapy. The ROS in cytoplasm can efficiently destroy the nanoplatform, leading to a rapid release of loaded drug and apoptosis of oral cancer cells.

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Green Tea Polyphenol Microparticles Based on the Oxidative Coupling of EGCG Inhibit Amyloid Aggregation/Cytotoxicity and Serve as a Platform for Drug Delivery

ACS Biomaterials Science & Engineering ◽

10.1021/acsbiomaterials.0c00188 ◽

2020 ◽

Vol 6 (8) ◽

pp. 4414-4423

Author(s):

Luiza Fernandes ◽

Beatriz Messias ◽

Antonio Pereira-Neves ◽

Estefania P. Azevedo ◽

Júlia Araújo ◽

...

Keyword(s):

Drug Delivery ◽

Green Tea ◽

Oxidative Coupling ◽

Amyloid Aggregation ◽

Tea Polyphenol ◽

Green Tea Polyphenol

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Stimulus-responsive tea polyphenols as nanocarrier for selective intracellular drug delivery

Journal of Biomaterials Applications ◽

10.1177/0885328220924539 ◽

2020 ◽

Vol 35 (2) ◽

pp. 149-157

Author(s):

Zhiheng Guo ◽

Yi Yang ◽

Yang Shu ◽

Li Qiao ◽

Min Peng ◽

...

Keyword(s):

Drug Delivery ◽

Tumor Cells ◽

Green Tea ◽

Tea Polyphenols ◽

Tea Polyphenol ◽

Nanodrug Delivery ◽

Chemotherapy Drug ◽

Green Tea Polyphenol ◽

Acid Environment

Nanodrug delivery systems have been widely researched to achieve efficient antitumor drug delivery. However, the controlled drug delivery at tumor cells remains the main challenge for antitumor therapy. Herein, a pH and reduction-responsive nanocarrier based on green tea polyphenols was employed as a smart excipient for chemotherapy drug delivery. Paclitaxel, as a chemotherapy drug, was loaded in the nanocarrier, noted as green tea polyphenol/paclitaxel. The green tea polyphenol/paclitaxel kept constant diameter at physiological condition (i.e. pH 7.4), while gradually enlarged at acid environment (pH = 5.5) and the reductive environment. The in vitro paclitaxel release results indicated that the release of paclitaxel from the green tea polyphenol/paclitaxel at pH 7.4 was slow, whereas obviously accelerated at the acid environment (pH = 5.5) and the reductive environment. The in vitro antitumor assay showed more efficient tumor cells inhibition of green tea polyphenol/paclitaxel than free paclitaxel. Meanwhile, due to the proper size (∼100 nm), green tea polyphenol/paclitaxel could effectively accumulate at tumor sites. In the in vivo mice bearing A549 xenograft mouse models, green tea polyphenol/paclitaxel exhibited satisfactory antitumor effect and depressed system toxicity when compared with free paclitaxel, owing to the enhanced paclitaxel accumulation and controlled paclitaxel release in the tumor cells. With simple compositions and satisfactory antitumor effects, this green tea polyphenol-based nanocarrier can be a promising nanodrug delivery system for the therapy of cancers.

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