Building better rechargeable Zn–Mn batteries with a highly active Mn3O4/carbon nanowire cathode and neutral Na2SO4/MnSO4 electrolyte

2018 ◽  
Vol 54 (77) ◽  
pp. 10835-10838 ◽  
Author(s):  
Lai Ma ◽  
Linpo Li ◽  
Yani Liu ◽  
Jianhui Zhu ◽  
Ting Meng ◽  
...  
Keyword(s):  
Power Supply ◽  
Great Promise ◽  
Battery System ◽  
Highly Active ◽  
Carbon Nanowire ◽  
Near Future ◽  
Carbon Nanowires

A more reliable/eco-friendly secondary Zn–Mn battery system is built with highly active Mn3O4@carbon nanowires and near-neutral electrolytes. Such configured batteries show high reversibility and superior behavior in terms of both stored capacity and cycling durability, holding great promise in near-future power-supply applications.

Potential Interventions Against BMPR2-Related Pulmonary Hypertension

2012 ◽  
Vol 11 (1) ◽  
pp. 25-32 ◽  
Author(s):  
James West ◽  
James E. Loyd ◽  
Rizwan Hamid
Keyword(s):  
Therapeutic Interventions ◽  
Great Promise ◽  
Patient Registries ◽  
Metabolic Defects ◽  
Pulmonary Arterial ◽  
Alternative Approaches ◽  
Splicing Defects ◽  
Trafficking Defects ◽  
Molecular Bases ◽  
Near Future

For more than 60 years, researchers have sought to understand the molecular basis of idiopathic pulmonary arterial hypertension (PAH). Recognition of the heritable form of the disease led to the creation of patient registries in the 1980s and 1990s, and discovery of BMPR2 as the cause of roughly 80% of heritable PAH in 2000. With discovery of the disease gene came opportunity for intervention, with focus on 2 alternative approaches. First, it may be possible to correct the effects of BMPR2 mutation directly through interventions targeted at correction of trafficking defects, increasing expression of the unmutated allele, and correction of splicing defects. Second, therapeutic interventions are being targeted at the signaling consequences of BMPR2 mutation. In particular, therapies targeting cytoskeletal and metabolic defects caused by BMPR2 mutation are currently in trials, or will be ready for human trials in the near future. Translation of these findings into therapies is the culmination of decades of research, and holds great promise for treatment of the underlying molecular bases of disease.

ADAPTIVE ALGORITHMS OF CONTROLLING THE SMART LI-ION BATTERY CONTROLLER

2018 ◽  
pp. 104-110
Author(s):  
I. A. Borovoy ◽  
O. V. Danishevskiy ◽  
A. V. Parfenov
Keyword(s):  
Power Supply ◽  
Power Supply System ◽  
Electric Energy ◽  
Lithium Ion ◽  
Control Device ◽  
Control Algorithms ◽  
Battery System ◽  
Electronic Control Device ◽  
Li Ion ◽  
Cell Balancing

The article substantiates the necessity of organizing the control system of modern lithium-ion batteries. Passive and active methods of cell balancing are described. The method of increase of efficiency of modes of accumulation of electric energy by means of the special electronic control device (the intellectual controller) and its further use for power supply of the functional equipment is considered. The structure of the intelligent controller as a part of the autonomous power supply system with the description of its main functional units and purpose is presented. Practical results of application in the intellectual controller of original adaptive control algorithms defining modes of operation of lithium-ion drives depending on various environmental conditions are resulted. The results of the analysis obtained by the results of experimental operation of the battery system, reflecting the qualitative and quantitative advantages of the proposed method.

scholarly journals A Siamese neural network model for the prioritization of metabolic disorders by integrating real and simulated data

2020 ◽  
Vol 36 (Supplement_2) ◽  
pp. i787-i794
Author(s):  
Gian Marco Messa ◽  
Francesco Napolitano ◽  
Sarah H. Elsea ◽  
Diego di Bernardo ◽  
Xin Gao
Keyword(s):  
Predictive Accuracy ◽  
Hybrid Approach ◽  
Simulated Data ◽  
Original Data ◽  
Diagnostic Process ◽  
Great Promise ◽  
Metabolic Profiles ◽  
Inborn Errors ◽  
Metabolomic Data ◽  
Near Future

Abstract Motivation Untargeted metabolomic approaches hold a great promise as a diagnostic tool for inborn errors of metabolisms (IEMs) in the near future. However, the complexity of the involved data makes its application difficult and time consuming. Computational approaches, such as metabolic network simulations and machine learning, could significantly help to exploit metabolomic data to aid the diagnostic process. While the former suffers from limited predictive accuracy, the latter is normally able to generalize only to IEMs for which sufficient data are available. Here, we propose a hybrid approach that exploits the best of both worlds by building a mapping between simulated and real metabolic data through a novel method based on Siamese neural networks (SNN). Results The proposed SNN model is able to perform disease prioritization for the metabolic profiles of IEM patients even for diseases that it was not trained to identify. To the best of our knowledge, this has not been attempted before. The developed model is able to significantly outperform a baseline model that relies on metabolic simulations only. The prioritization performances demonstrate the feasibility of the method, suggesting that the integration of metabolic models and data could significantly aid the IEM diagnosis process in the near future. Availability and implementation Metabolic datasets used in this study are publicly available from the cited sources. The original data produced in this study, including the trained models and the simulated metabolic profiles, are also publicly available (Messa et al., 2020).

scholarly journals Prospects for p53-based cancer therapy.

2005 ◽  
Vol 52 (2) ◽  
pp. 321-328 ◽  
Author(s):  
Tomasz Stokłosa ◽  
Jakub Gołab
Keyword(s):  
Human Tumor ◽  
P53 Gene ◽  
Great Promise ◽  
Mutant Form ◽  
Wild Type ◽  
P53 Pathway ◽  
Cycle Arrest ◽  
Stress Signals ◽  
Near Future

The p53 tumor suppressor plays the role of a cellular hub which gathers stress signals such as damage to DNA or hypoxia and translates them into a complex response. p53 exerts its action mainly as a potent transcription factor. The two major outcomes of p53 activity are highlighted: cell cycle arrest and apoptosis. During malignant transformation p53 or p53-pathway related molecules are disabled extremely often. Mutations in p53 gene are present in every second human tumor. A mutant form of p53 may not only negate the wild type p53 function but may play additional role in tumor progression. Therefore p53 represents a relatively unique and specific target for anticancer drug design. Current approaches include several different molecules able to restore p53 wild-type conformation and activity. Such small molecule drugs hold great promise in treating human tumors with dysfunction of p53 pathway in the near future.

scholarly journals New Building Cladding System Using Independent Tilted BIPV Panels with Battery Storage Capability

2019 ◽  
Vol 11 (20) ◽  
pp. 5546 ◽  
Author(s):  
Amy A. Kim ◽  
Dorothy A. Reed ◽  
Youngjun Choe ◽  
Shuoqi Wang ◽  
Carolina Recart
Keyword(s):  
Power Generation ◽  
Renewable Energy ◽  
Building Energy ◽  
Battery System ◽  
Operation And Maintenance ◽  
Building Integrated Photovoltaic ◽  
Cladding Panels ◽  
Improved Design ◽  
Storage Batteries ◽  
Near Future

In order to meet renewable energy goals in the near future, the deployment of photovoltaic (PV) panels on buildings will dramatically increase. The objective of this paper is to introduce an improved design for PV cladding systems that will greatly contribute to meeting these renewable energy goals. Typically, building-integrated photovoltaic (BIPV) panels are vertically oriented as cladding and they are not coupled with individual storage batteries. The proposed cladding couples a tilted BIPV panel with one or more storage batteries at each building placement. Thus, the tilted BIPV plus battery system is independent of other power generation in the building and it is referred to as a “building perma-power link” (BPPL) cladding element. Each cladding panel is designed as a stand-alone system, which will be useful for installation, operation, and maintenance. The hyper-redundancy of multiple BPPL cladding panels for a typical building significantly enhances its overall energy resiliency. In order to foster manufacturing ease, each individual cladding unit has been designed at tilts of 45° and 60°. An example of a mid-rise building in Seattle, Washington is provided. The degree of building energy resiliency provided through multiple BPPLs is examined.

Hybrid System of Proton Exchange Membrane Fuel Cell (PEMFC) with Battery for Portable Power Supply

2018 ◽  
Vol 7 (3.34) ◽  
pp. 542 ◽  
Author(s):  
Prakash Thapa ◽  
Sung Gi Kwon ◽  
Jin Lee ◽  
Gye Choon Park
Keyword(s):  
Fuel Cell ◽  
Hybrid System ◽  
Power Supply ◽  
Power Supply System ◽  
Supply System ◽  
Advanced Technology ◽  
Li Ion Battery ◽  
Battery System ◽  
Li Ion ◽  
Continuous Power

Background/Objectives: The combustion of fossil fuels and increased number of advanced technology leads to the global warming and climate change. So, to reduce the greenhouse gas emission and conserve the energy we need to use green energy like fuel cell and Li-ion battery system. This hybrid system consists of PEM fuel cell stack, Li-ion battery and bidirectional step up converter and can be used stationary as well as mobile equipment like vehicles.Methods/Statistical analysis: For the analysis of hybrid PEMFC/ Li-ion battery power supply system, portable embedded motor is proposed in this paper. The modeling, design, implementation and performance of hybrid system are demonstrate by using experimental results as well as MATLAB/Simulink.Findings: The simulation results shows that hybrid fuel cell-battery system could provide the continuous power to the sudden changing load and protect the devices. The results also shows that, bidirectional controller can successfully control the fuel cell output and maintain the state of charge of battery at a constant level which provides the significant efficiency of the hybrid power supply system and increased the life-cycle of the system more than 35%.Improvements/Applications: To improve the fuel cell system performance we need to provide the favorable conditions of temperature, pressure, humidity and control the flow rate of reactant gausses. Similarly, due to internal resistance, temperature, material used in manufacturing process, charging and discharging strategy reduces the efficiency as well as life of the battery pack. By using proper voltage balancing methodology we can maintain the similar voltage and prevent from irregular charging. 

scholarly journals Self-Healing Thermoplastic Polyurethane Linked via Host-Guest Interactions

Polymers ◽  
2020 ◽  
Vol 12 (6) ◽  
pp. 1393 ◽  
Author(s):  
Changming Jin ◽  
Garry Sinawang ◽  
Motofumi Osaki ◽  
Yongtai Zheng ◽  
Hiroyasu Yamaguchi ◽  
...  
Keyword(s):  
Thermoplastic Polyurethane ◽  
Bulk Polymerization ◽  
Hexamethylene Diisocyanate ◽  
Great Promise ◽  
Tetraethylene Glycol ◽  
Self Healing ◽  
Rupture Stress ◽  
Materials Research ◽  
Step Growth ◽  
Near Future

High toughness with self-healing ability has become the ultimate goal in materials research. Herein, thermoplastic polyurethane (TPU) was linked via host-guest (HG) interactions to increase its mechanical properties and self-healing ability. TPU linked via HG interactions was prepared by the step-growth bulk polymerization of hexamethylene diisocyanate (HDI), tetraethylene glycol (TEG), and HG interactions between permethylated amino βCD (PMeAmβCD) and adamantane amine (AdAm). TPU linked with 10 mol% of HG interactions (HG(10)) showed the highest rupture stress and fracture energy (GF) of 11 MPa and 25 MJ·m−3, which are almost 40-fold and 1500-fold, respectively, higher than those of non-functionalized TEG-based TPU (PU). Additionally, damaged HG(10) shows 87% recovery after heated for 7 min at 80 °C, and completely cut HG(10) shows 80% recovery after 60 min of reattachment at same temperature. The HG interactions in TPU are an important factor in stress dispersion, increasing both its mechanical and self-healing properties. The TPU linked via HG interactions has great promise for use in industrial materials in the near future.

scholarly journals Synthetic Promoter Designs Enabled by a Comprehensive Analysis of Plant Core Promoters

2021 ◽  
Author(s):  
Tobias Jores ◽  
Jackson Tonnies ◽  
Travis Wrightsman ◽  
Edward S. Buckler ◽  
Josh Cuperus ◽  
...  
Keyword(s):  
Computational Models ◽  
Core Promoter ◽  
Gc Content ◽  
Regulatory Elements ◽  
Great Promise ◽  
35S Promoter ◽  
Promoter Strength ◽  
Promoter Elements ◽  
Native Promoter ◽  
Highly Active

Targeted engineering of plant gene expression holds great promise for ensuring food security and for producing biopharmaceuticals in plants. However, this engineering requires thorough knowledge of cis-regulatory elements in order to precisely control either endogenous or introduced genes. To generate this knowledge, we used a massively parallel reporter assay to measure the activity of nearly complete sets of promoters from Arabidopsis, maize and sorghum. We demonstrate that core promoter elements - notably the TATA-box - as well as promoter GC content and promoter-proximal transcription factor binding sites influence promoter strength. By performing the experiments in two assay systems, leaves of the dicot tobacco and protoplasts of the monocot maize, we detected species-specific differences in the contributions of GC content and transcription factors to promoter strength. Using these observations, we built computational models to predict promoter strength in both assay systems, allowing us to design highly active promoters comparable in activity to the viral 35S promoter. Our results establish a promising experimental approach to optimize native promoter elements and generate synthetic ones with desirable features.

scholarly journals SELECTION OF THE LAYOUT OF THE MAIN SYSTEMS OF A HEAVY MULTICOPTER TAKING INTO ACCOUNT THE REQUIREMENTS OF AVIATION REGULATION

2021 ◽  
pp. 54-66
Author(s):  
Aleksey Trofimov ◽  
◽  
Sergej Postnikov ◽  
Keyword(s):  
Control System ◽  
Power Supply ◽  
Power Supply System ◽  
Urban Environments ◽  
Supply System ◽  
Large Cities ◽  
Thrust Generation ◽  
Transport Vehicle ◽  
And Control ◽  
Near Future

This article discusses the possibility of using a multicopter type aircraft as a transport vehicle in urban environments. This type of transport is the most promising in the near future, given the constantly growing number of traffic jams in large cities. The assessment of this aircraft is presented, taking into account the reliability requirements specified in the regulatory documents. The analysis of the aviation regulations requirements in terms of the aircraft systems reliability was carried out. Also the paper presents six options for the multicopter layout with a different number of propellers, taking into account the propeller control system, power supply system and control system. Other onboard systems are not considered, since their failures do not lead to an aircraft crash. An assessment of these options, taking into account the multicopter most critical onboard equipment layout according to reliability criterion by budgeting the requirements for one thrust generation channel, is given. Fault trees and failure situations that lead to a disastrous situation are also presented for each multicopter layout separately, as well as proposals for the number of independent channels for the power supply system and control system. Based on the set quantitative requirements for the occurrence of a catastrophic situation for the main on-board equipment and various layout options, taking into account the number of propellers and proposals for their architecture, power supply systems and control systems the most promising multicopter architecture options are determined. They meet the requirements for failure safety for a catastrophic situation.

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