scholarly journals Biodegradable multi-walled carbon nanotubes trigger anti-tumoral effects

Nanoscale ◽  
2018 ◽  
Vol 10 (23) ◽  
pp. 11013-11020 ◽  
Author(s):  
E. González-Lavado ◽  
N. Iturrioz-Rodríguez ◽  
E. Padín-González ◽  
J. González ◽  
L. García-Hevia ◽  
...  
Keyword(s):  
Carbon Nanotubes ◽  
Malignant Melanoma ◽  
Solid Tumors ◽  
Mild Oxidation ◽  
Multi Walled Carbon Nanotubes ◽  
Walled Carbon Nanotubes

Mild oxidation treatments improve the in vitro and in vivo macrophage biodegradation of carbon nanotubes that trigger remarkable anti-tumoral effects in malignant melanoma solid tumors produced in mice.

scholarly journals PDLLA honeycomb-like scaffolds with a high loading of superhydrophilic graphene/multi-walled carbon nanotubes promote osteoblast in vitro functions and guided in vivo bone regeneration

2017 ◽  
Vol 73 ◽  
pp. 31-39 ◽  
Author(s):  
Edmundo Silva ◽  
Luana Marotta Reis de Vasconcellos ◽  
Bruno V.M. Rodrigues ◽  
Danilo Martins dos Santos ◽  
Sergio P. Campana-Filho ◽  
...  
Keyword(s):  
Carbon Nanotubes ◽  
Bone Regeneration ◽  
High Loading ◽  
Multi Walled Carbon Nanotubes ◽  
Walled Carbon Nanotubes

scholarly journals Production, characterization and immobilization of Aspergillus versicolor L-asparaginase onto multi-walled carbon nanotubes

2020 ◽  
Vol 10 (4) ◽  
pp. 5733-5740
Keyword(s):  
Carbon Nanotubes ◽  
Production Condition ◽  
Physical Adsorption ◽  
Maximum Yield ◽  
Normal Fibroblast ◽  
Aspergillus Versicolor ◽  
Multi Walled Carbon Nanotubes ◽  
Walled Carbon Nanotubes

The goal of this work is to study the optimum production of L-ASNase and the influence of oxidized multi-walled carbon nanotubes (ox-MWCNTs) on the biological activity of the isolated L-ASNase. Isolation and production of L-ASNase from different screened fungi in the presence of L-asparagine substrate were carried out. The isolated enzyme was identified by molecular18S rRNA analysis. The partial purified L-ASNase having 6.77 purification fold was immobilized onto ox-MWCNTs using physical adsorption technique with maximum yield about 54.4%. In vitro cytotoxicity of L-ASNase against normal fibroblast cell line (BHK-21) was examined relative to the immobilized one using SRB assay. Also, in vivo biological examination using liver and kidney dysfunction biomarkers in the treated mice (AST, ALT, LDH, lipase and α-amylase) was also investigated. Among the ten screened fungi, Aspergillus versicolor was the most potent one with maximum activity about 45.5 U/mL. The results showed that the most appropriate production condition was at asparagine concentration of about 0.04 M and pH 8. The immobilized L-ASNase retained a complete activity (100%) after 30 min at 45ᴼC of incubation relative to that in case of the free one. The toxicity of L-ASNase was significantly decreased up to 50 μg/mL after immobilization onto MWCNTs. Besides, the immobilized L-ASNase exhibited good storage ability and stability at high temperature relative to that in case of the free one.

The Effects of the Coating of Anodized Titanium with Multi-Walled Carbon Nanotubes on Bone Formation

2012 ◽  
Vol 529-530 ◽  
pp. 621-624
Author(s):  
Saori Inoue ◽  
Motohiro Uo ◽  
Masatoshi Sakairi ◽  
Eri Hirata ◽  
Min Ho Lee ◽  
...  
Keyword(s):  
Carbon Nanotubes ◽  
Bone Formation ◽  
Bone Tissue ◽  
Biological Properties ◽  
Adhesion Protein ◽  
Multi Walled Carbon Nanotubes ◽  
Anodized Titanium ◽  
Walled Carbon Nanotubes

Carbon nanotubes (CNTs) have excellent chemical, physical, and biological properties such as strong cell adhesion, protein adsorption and cell proliferationin vitro. Excellent osteocompatibility for the CNT monolith was also reported in vivo. The purpose of this study was to evaluate the effects of anodized titanium coated with multiwalled CNTs (MWCNTs) on human osteosarcoma Saos2 cells and bone tissue. Saos2 cells on CNT-Ti showed excellent proliferation with extension of cell morphology in all directions. CNT-Ti wire was implanted in the bone marrow of femurs of rats. At 2 weeks after surgery, histological investigations revealed that bone tissue attached to the surface of the CNT-Ti directly. Thus the surface modification of anodized Ti by MWCNTs can be effective for bone formation.

scholarly journals Organ Specific Toxicity of Single and Multi-Walled Carbon Nanotubes: A Review

2020 ◽  
Vol V (I) ◽  
pp. 48-57
Author(s):  
Maria Hassan Kiani ◽  
Ayesha Batool ◽  
Maheen Khurshid ◽  
Memoona Kanwal ◽  
Naveed Ahmed
Keyword(s):  
Carbon Nanotubes ◽  
Mechanisms Of Toxicity ◽  
Toxicological Effects ◽  
Carbon Structures ◽  
Organ Specific ◽  
Physicochemical Features ◽  
Multi Walled Carbon Nanotubes ◽  
Walled Carbon Nanotubes

Carbon nanotubes are one of the most widely investigated carbon structures because of variety of physicochemical features offered by them. Their dimensions, surface chemistry and functionalization opportunities make them exceptional carrier for targeted drug delivery gene therapy, diagnosis and cell imaging. Both single and multi-walled CNTs have been functionalized for therapeutic applications. However, these structures have been associated with potential in vitro and in vivo cytotoxic effects. Such toxicities have been described to involve both cellular and subcellular mechanisms. Major organs that have shown significant CNTs related toxic effects include lungs, brain, heart, kidney, liver and skin. This review focuses on the potential toxicological effects of single and multi-walled carbon nanotubes and functionalization on these organs and associated mechanisms of toxicity

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