Emerging applications of peptide–oligonucleotide conjugates: bioactive scaffolds, self-assembling systems, and hybrid nanomaterials

2019 ◽  
Vol 17 (7) ◽  
pp. 1668-1682 ◽  
Author(s):  
Tara MacCulloch ◽  
Alex Buchberger ◽  
Nicholas Stephanopoulos
Keyword(s):  
Synthetic Peptide ◽  
Hybrid Nanomaterials ◽  
Bioactive Scaffolds ◽  
Self Assembling ◽  
Oligonucleotide Conjugates

Peptide–oligonucleotide conjugates (POCs) are covalent constructs that link a molecule like DNA to a synthetic peptide sequences.

scholarly journals Structural analysis of cross α-helical nanotubes provides insight into the designability of filamentous peptide nanomaterials

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Fengbin Wang ◽  
Ordy Gnewou ◽  
Charles Modlin ◽  
Leticia C. Beltran ◽  
Chunfu Xu ◽  
...  
Keyword(s):  
Structural Analysis ◽  
Synthetic Peptide ◽  
Quaternary Structure ◽  
De Novo ◽  
Rational Approach ◽  
Lateral Interactions ◽  
Protein Assemblies ◽  
Self Assembling ◽  
Arginine Residues ◽  
Insight Into

AbstractThe exquisite structure-function correlations observed in filamentous protein assemblies provide a paradigm for the design of synthetic peptide-based nanomaterials. However, the plasticity of quaternary structure in sequence-space and the lability of helical symmetry present significant challenges to the de novo design and structural analysis of such filaments. Here, we describe a rational approach to design self-assembling peptide nanotubes based on controlling lateral interactions between protofilaments having an unusual cross-α supramolecular architecture. Near-atomic resolution cryo-EM structural analysis of seven designed nanotubes provides insight into the designability of interfaces within these synthetic peptide assemblies and identifies a non-native structural interaction based on a pair of arginine residues. This arginine clasp motif can robustly mediate cohesive interactions between protofilaments within the cross-α nanotubes. The structure of the resultant assemblies can be controlled through the sequence and length of the peptide subunits, which generates synthetic peptide filaments of similar dimensions to flagella and pili.

Hexacyano octahedral metallic clusters as versatile building blocks in the design of extended polymeric framework and clustomesogens

2014 ◽  
Vol 2 (46) ◽  
pp. 9813-9823 ◽  
Author(s):  
Maria Amela-Cortes ◽  
Stéphane Cordier ◽  
Nikolay G. Naumov ◽  
Cristelle Mériadec ◽  
Franck Artzner ◽  
...  
Keyword(s):  
Liquid Crystal ◽  
Building Blocks ◽  
Metallic Cluster ◽  
Intrinsic Properties ◽  
Hybrid Nanomaterials ◽  
Metallic Clusters ◽  
Self Assembling ◽  
Crystal Phases ◽  
Polymeric Framework ◽  
Liquid Crystal Phases

Self-assembling abilities of Katn[M6Qi8(CN)a6] hybrid nanomaterials are tailored by the metallic cluster polyanionic charge while the latter keeps its intrinsic properties within the liquid crystal phases.

Tailoring the self-assembling abilities of functional hybrid nanomaterials: from rod-like to disk-like clustomesogens based on a luminescent {Mo6Br8}4+ inorganic cluster core

2018 ◽  
Vol 6 (10) ◽  
pp. 2556-2564 ◽  
Author(s):  
Aurore Gandubert ◽  
Maria Amela-Cortes ◽  
Susanta Kumar Nayak ◽  
Cristian Vicent ◽  
Cristelle Mériadec ◽  
...  
Keyword(s):  
Hybrid Materials ◽  
The Self ◽  
Cluster Core ◽  
Metallic Cluster ◽  
Hybrid Nanomaterials ◽  
Ligand Density ◽  
Self Assembling

Self-assembling abilities of hybrid materials are controlled by modifying the ligand density around an emissive bulky metallic cluster core.

Biomaterials for Brain Tissue Engineering

2010 ◽  
Vol 63 (8) ◽  
pp. 1143 ◽  
Author(s):  
Jerani T. S. Pettikiriarachchi ◽  
Clare L. Parish ◽  
Molly S. Shoichet ◽  
John S. Forsythe ◽  
David R. Nisbet
Keyword(s):  
Brain Tissue ◽  
Brain Injuries ◽  
Treatment Strategies ◽  
Neuronal Loss ◽  
Current Treatment ◽  
Brain Parenchyma ◽  
Bioactive Scaffolds ◽  
Self Assembling ◽  
Electrospun Nanofibres

Neurological disorders such as traumatic brain injuries or stroke result in neuronal loss and disruption of the brain parenchyma. Current treatment strategies are limited in that they can only mitigate the degeneration process or alleviate the symptoms but do not reverse the condition. In contrast, regenerative cell-based therapies offer long-term hope for many patients. Bioactive scaffolds are likely to reinforce the success of cell replacement therapies by providing a microenvironment that facilitates the survival, proliferation, differentiation, and connectivity of transplanted and/or endogenous cells. This Review outlines various biomaterials (including hydrogels, self-assembling peptides, and electrospun nanofibres) that have been investigated for the repair of brain tissue, and discusses strategies for the immobilization of biomolecules. An overview of the potential clinical applications of such scaffolds in neurodegenerative diseases is also provided.

scholarly journals Self-assembling, self-adjuvanting and fully synthetic peptide nanovaccine for cancer immunotherapy

2021 ◽  
Author(s):  
Huijuan Song ◽  
Qi Su ◽  
Pingsheng Huang ◽  
Chuangnian Zhang ◽  
Weiwei Wang
Keyword(s):  
Cancer Immunotherapy ◽  
Synthetic Peptide ◽  
Self Assembling

Torus Circumference and Thickness Parameters From a Linear DNA Size Series Suggest How Toruses Self-Assemble

1985 ◽  
Vol 43 ◽  
pp. 522-523
Author(s):  
George C. Ruben ◽  
Kenneth A. Marx
Keyword(s):  
Tertiary Structure ◽  
Dna Complexes ◽  
Tertiary Structures ◽  
Self Assembling ◽  
Double Stranded Dna ◽  
Calf Thymus ◽  
Dna Organization ◽  
Condensed Dna ◽  
Dna Size

Certain double stranded DNA bacteriophage and viruses are thought to have their DNA organized into large torus shaped structures. Morphologically, these poorly understood biological DNA tertiary structures resemble spermidine-condensed DNA complexes formed in vitro in the total absence of other macromolecules normally synthesized by the pathogens for the purpose of their own DNA packaging. Therefore, we have studied the tertiary structure of these self-assembling torus shaped spermidine- DNA complexes in a series of reports. Using freeze-etch, low Pt-C metal (10-15Å) replicas, we have visualized the microscopic DNA organization of both calf Thymus( CT) and linear 0X-174 RFII DNA toruses. In these structures DNA is circumferentially wound, continuously, around the torus into a semi-crystalline, hexagonal packed array of parallel DNA helix sections.

Structure–property studies of self-assembling [n.n]paracyclophanes

2020 ◽  
Author(s):  
Will R Henderson ◽  
Danielle E. Fagnani ◽  
Yu Zhu ◽  
Guancen Liu ◽  
Ronald K. Castellano
Keyword(s):  
Structure Property ◽  
Self Assembling
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