A liposomal curcumol nanocomposite for magnetic resonance imaging and endoplasmic reticulum stress-mediated chemotherapy of human primary ovarian cancer

2019 ◽  
Vol 7 (18) ◽  
pp. 2938-2947 ◽  
Author(s):  
Jing Wang ◽  
Yonghong Song ◽  
Mingxun Zhang ◽  
Zhensheng Wu ◽  
Yun-Jun Xu ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Ovarian Cancer ◽  
Endoplasmic Reticulum ◽  
Magnetic Resonance ◽  
Endoplasmic Reticulum Stress ◽  
Tumor Tissue ◽  
Ovarian Cancer Cells ◽  
Resonance Imaging ◽  
Primary Ovarian Cancer ◽  
Solid Tumor Tissue

A liposomal curcumol nanocomposite has been successfully synthesized for the theranostics of human primary ovarian cancer cells from solid tumor tissue in patients.

Aptamer modified nanoprobe for multimodal fluorescence/magnetic resonance imaging of human ovarian cancer cells

2021 ◽  
Vol 127 (1) ◽  
Author(s):  
Mahdi Asgari ◽  
Hossein Khanahmad ◽  
Hasan Motaghi ◽  
Amin Farzadniya ◽  
Masoud A. Mehrgardi ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Ovarian Cancer ◽  
Magnetic Resonance ◽  
Cancer Cells ◽  
Ovarian Cancer Cells ◽  
Human Ovarian Cancer ◽  
Resonance Imaging

scholarly journals Magnetic resonance imaging for the non-invasive diagnosis in patients with ovarian cancer

Medicine ◽  
2020 ◽  
Vol 99 (50) ◽  
pp. e23551
Author(s):  
Yongxue Su ◽  
Lingli Deng ◽  
Lijun Yang ◽  
Xianhong Yuan ◽  
Wei Xia ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Ovarian Cancer ◽  
Magnetic Resonance ◽  
Resonance Imaging ◽  
Non Invasive

scholarly journals Fucosterol Suppresses the Progression of Human Ovarian Cancer by Inducing Mitochondrial Dysfunction and Endoplasmic Reticulum Stress

Marine Drugs ◽  
2020 ◽  
Vol 18 (5) ◽  
pp. 261 ◽  
Author(s):  
Hyocheol Bae ◽  
Jin-Young Lee ◽  
Gwonhwa Song ◽  
Whasun Lim
Keyword(s):  
Ovarian Cancer ◽  
Endoplasmic Reticulum ◽  
Endoplasmic Reticulum Stress ◽  
Cancer Cells ◽  
Cell Cycle Progression ◽  
Xenograft Model ◽  
Tumor Formation ◽  
Ovarian Cancer Cells ◽  
Human Ovarian Cancer ◽  
Anticancer Properties

Ovarian cancer is difficult to diagnose early and has high rates of relapse and mortality. Therefore, the treatment of ovarian cancer needs to be improved. Recently, several studies have been conducted in an attempt to develop anticancer drugs from naturally derived ingredients. Compared to traditional chemotherapy, natural compounds can overcome drug resistance with lower side effects. Fucosterol, a phytosterol present in brown algae, reportedly possesses many bioactive effects, including anticancer properties. However, the anticancer effects of fucosterol in ovarian cancer remain unexplored. Therefore, we investigated the effects of fucosterol on progression in human ovarian cancer cells. Fucosterol inhibited cell proliferation and cell-cycle progression in ovarian cancer cells. Additionally, fucosterol regulated the proliferation-related signaling pathways, the production of reactive oxygen species, mitochondrial function, endoplasmic reticulum stress, angiogenesis, and calcium homeostasis. Moreover, it decreased tumor formation in a zebrafish xenograft model. These results indicate that fucosterol could be used as a potential therapeutic agent in ovarian cancer.

Gadolinium-DTPA Enhancement of Experimental Soft Tissue Carcinoma and Hemorrhage in Magnetic Resonance Imaging

1987 ◽  
Vol 28 (1) ◽  
pp. 75-78 ◽  
Author(s):  
H. Pettersson ◽  
N. Ackerman ◽  
J. Kaude ◽  
R. E. Googe ◽  
A. A. Mancuso ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Body Weight ◽  
Magnetic Resonance ◽  
Tumor Tissue ◽  
Soft Tissues ◽  
Relaxation Times ◽  
Resonance Imaging ◽  
Benign Lesions ◽  
Gadolinium Dtpa ◽  
T1 Relaxation

An experimental series in the rabbit was performed to test gadolinium-DTPA (Gd-DTPA) enhancement of VX-2 carcinoma and hemorrhages induced in the soft tissues. The recognition of both malignant and benign lesions was greatly facilitated on T1 weighted images after intravenous administration of 0.3 mmol Gd-DTPA/kg body weight because of reduced T1 relaxation times. Gd-DTPA enhancement reached its maximum after 10–15 minutes and was most apparent in tumor tissue, connective tissue surrounding the tumor and in the area of fresh hemorrhage.

Sign in / Sign up

Export Citation Format

Share Document