Enhanced mechanical and biological characteristics of PLLA composites through surface grafting of oligolactide on magnesium hydroxide nanoparticles

2020 ◽  
Vol 8 (7) ◽  
pp. 2018-2030 ◽  
Author(s):  
Eun Young Kang ◽  
Sung-Bin Park ◽  
Bogyu Choi ◽  
Seung-Woon Baek ◽  
Kyoung-Won Ko ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Lactic Acid ◽  
Magnesium Hydroxide ◽  
Biological Properties ◽  
Biological Characteristics ◽  
Surface Grafting ◽  
Surface Modified ◽  
Magnesium Hydroxide Nanoparticles

Surface-modified magnesium hydroxide (MH) was incorporated to not only improve physico-mechanical properties but also enhance biological properties of Poly(l-lactic acid) (PLLA) more effectively.

scholarly journals Poly(L-Lactic Acid) Composite with Surface-Modified Magnesium Hydroxide Nanoparticles by Biodegradable Oligomer for Augmented Mechanical and Biological Properties

Materials ◽  
2021 ◽  
Vol 14 (19) ◽  
pp. 5869
Author(s):  
Seung-Woon Baek ◽  
Duck Hyun Song ◽  
Ho In Lee ◽  
Da-Seul Kim ◽  
Yun Heo ◽  
...  
Keyword(s):  
Lactic Acid ◽  
Magnesium Hydroxide ◽  
Inflammatory Responses ◽  
Biological Properties ◽  
Control Group ◽  
Biomedical Materials ◽  
Vascular Scaffolds ◽  
Surface Modified ◽  
Ph Neutralization

Poly(L-lactic acid) (PLLA) has attracted a great deal of attention for its use in biomedical materials such as biodegradable vascular scaffolds due to its high biocompatibility. However, its inherent brittleness and inflammatory responses by acidic by-products of PLLA limit its application in biomedical materials. Magnesium hydroxide (MH) has drawn attention as a potential additive since it has a neutralizing effect. Despite the advantages of MH, the MH can be easily agglomerated, resulting in poor dispersion in the polymer matrix. To overcome this problem, oligo-L-lactide-ε-caprolactone (OLCL) as a flexible character was grafted onto the surface of MH nanoparticles due to its acid-neutralizing effect and was added to the PLLA to obtain PLLA/MH composites. The pH neutralization effect of MH was maintained after surface modification. In an in vitro cell experiment, the PLLA/MH composites including OLCL-grafted MH exhibited lower platelet adhesion, cytotoxicity, and inflammatory responses better than those of the control group. Taken together, these results prove that PLLA/MH composites including OLCL-grafted MH show excellent augmented mechanical and biological properties. This technology can be applied to biomedical materials for vascular devices such as biodegradable vascular scaffolds.

The crystallization behaviors and mechanical properties of poly(l-lactic acid)/magnesium oxide nanoparticle composites

RSC Advances ◽  
2016 ◽  
Vol 6 (50) ◽  
pp. 43855-43863 ◽  
Author(s):  
Junping Jia ◽  
Jinjun Yang ◽  
Yun Zhao ◽  
Hui Liang ◽  
Minfang Chen
Keyword(s):  
Mechanical Properties ◽  
Lactic Acid ◽  
Magnesium Oxide ◽  
Solution Casting ◽  
Casting Method ◽  
Oxide Composite ◽  
Solution Casting Method ◽  
Oxide Nanoparticle ◽  
Surface Modified ◽  
Nanoparticle Composites

Nanocomposites of biodegradable PLLA and magnesium oxide composite (PLLA/MgO-NPs) and surface modified magnesium oxide composite (PLLA/m-MgO-NPs) were prepared using a solution casting method.

Effect of magnesium hydroxide nanoparticles with rod and plate shape on mechanical and biological properties of poly(L-lactide) composites

2014 ◽  
Vol 22 (9) ◽  
pp. 1032-1041 ◽  
Author(s):  
Chang Hun Kum ◽  
Seong Ho Seo ◽  
Sung Nam Kang ◽  
Bang Ju Park ◽  
Dong June Ahn ◽  
...  
Keyword(s):  
Magnesium Hydroxide ◽  
Biological Properties ◽  
Plate Shape ◽  
Magnesium Hydroxide Nanoparticles

Morphology and Mechanical Properties of Poly (Lactic Acid) and Acrylonitrile-Butadiene Rubber Blends with Organoclay

2016 ◽  
Vol 835 ◽  
pp. 284-288 ◽  
Author(s):  
Sirirat Wacharawichanant ◽  
Chawisa Wisuttrakarn ◽  
Kasana Chomphunoi
Keyword(s):  
Mechanical Properties ◽  
Lactic Acid ◽  
Poly Lactic Acid ◽  
Butadiene Rubber ◽  
Melt Mixing ◽  
Rubber Blends ◽  
Acrylonitrile Butadiene Rubber ◽  
Electron Microscopy Analysis ◽  
Surface Modified ◽  
Morphology And Mechanical Properties

The effects of the montmorillonite clay surface modified with 25-30 wt% of methyl dihydroxyethyl hydrogenated tallow ammonium (Clay-MHA) on morphology and mechanical properties of poly(lactic acid) (PLA)/acrylonitrile-butadiene rubber copolymer (NBR)/Clay-MHA composites were investigated. The composites of blends of PLA/NBR with Clay-MHA were prepared by melt mixing in an internal mixer and molded by compression molding. The ratio of PLA and NBR was 80/20 by weight and the Clay-MHA content was 1, 3, 5 and 7 phr. The results showed Young’s modulus and stress at break of the composites increased with increasing Clay-MHA content. While the tensile strength and strain at break of the composites decreased with increasing Clay-MHA content. Scanning electron microscopy analysis showed that the addition of Clay-MHA could improve the miscibility of PLA and NBR to be homogeneous blends and the pore in polymer blends was disappeared.

scholarly journals Controlling the Antimicrobial Action of Surface Modified Magnesium Hydroxide Nanoparticles

Biomimetics ◽  
2019 ◽  
Vol 4 (2) ◽  
pp. 41 ◽  
Author(s):  
Ahmed F. Halbus ◽  
Tommy S. Horozov ◽  
Vesselin N. Paunov
Keyword(s):  
Electron Microscopy ◽  
Antimicrobial Activity ◽  
Magnesium Hydroxide ◽  
Inorganic Nanoparticles ◽  
X Ray Diffraction ◽  
X Ray ◽  
E Coli ◽  
Transmission Electron ◽  
Surface Modified ◽  
Magnesium Hydroxide Nanoparticles

Magnesium hydroxide nanoparticles (Mg(OH)2NPs) have recently attracted significant attention due to their wide applications as environmentally friendly antimicrobial nanomaterials, with potentially low toxicity and low fabrication cost. Here, we describe the synthesis and characterisation of a range of surface modified Mg(OH)2NPs, including particle size distribution, crystallite size, zeta potential, isoelectric point, X-ray diffraction (XRD), dynamic light scattering (DLS), scanning electron microscopy (SEM), thermogravimetric analysis (TGA), energy dispersive X-ray analysis (EDX), Fourier transform infrared spectroscopy (FTIR), and transmission electron microscopy (TEM). We explored the antimicrobial activity of the modified Mg(OH)2NPs on the microalgae (C. reinhardtii), yeast (S. cerevisiae) and Escherichia coli (E. coli). The viability of these cells was evaluated for various concentrations and exposure times with Mg(OH)2NPs. It was discovered that the antimicrobial activity of the uncoated Mg(OH)2NPs on the viability of C. reinhardtii occurred at considerably lower particle concentrations than for S. cerevisiae and E. coli. Our results indicate that the antimicrobial activity of polyelectrolyte-coated Mg(OH)2NPs alternates with their surface charge. The anionic nanoparticles (Mg(OH)2NPs/PSS) have much lower antibacterial activity than the cationic ones (Mg(OH)2NPs/PSS/PAH and uncoated Mg(OH)2NPs). These findings could be explained by the lower adhesion of the Mg(OH)2NPs/PSS to the cell wall, because of electrostatic repulsion and the enhanced particle-cell adhesion due to electrostatic attraction in the case of cationic Mg(OH)2NPs. The results can be potentially applied to control the cytotoxicity and the antimicrobial activity of other inorganic nanoparticles.

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