Novel aza-BODIPY based small molecular NIR-II fluorophores for in vivo imaging

2019 ◽  
Vol 55 (73) ◽  
pp. 10920-10923 ◽  
Author(s):  
Lei Bai ◽  
Pengfei Sun ◽  
Yi Liu ◽  
Hang Zhang ◽  
Wenbo Hu ◽  
...  
Keyword(s):  
In Vivo Imaging ◽  
Photophysical Properties ◽  
Stokes Shift ◽  
Imaging Agents ◽  
Large Stokes Shift ◽  
New Class

A new class of small molecular NIR-II fluorophores based on aza-BODIPY with promising photophysical properties (large Stokes shift, superior photostability, good fluorescence brightness), show great potential as NIR-II in vivo imaging agents.

Stable Twisted Conformation Aza-BODIPY NIR-II Fluorescent Nanoparticles with Ultra-large Stokes Shift for Imaging-Guided Phototherapy

2022 ◽  
Author(s):  
Youliang Tian ◽  
Huiting Zhou ◽  
Quan Cheng ◽  
Huiping Dang ◽  
Hongyun Qian ◽  
...  
Keyword(s):  
Fluorescence Imaging ◽  
In Vivo Imaging ◽  
Near Infrared ◽  
Stokes Shift ◽  
Great Promise ◽  
Deep Penetration ◽  
Fluorescent Nanoparticles ◽  
Spatiotemporal Resolution ◽  
Large Stokes Shift

Fluorescence imaging in the second near-infrared window (NIR-II, 1000–1700 nm) holds great promise for in vivo imaging and imaging-guided phototherapy with deep penetration and high spatiotemporal resolution. It is very...

scholarly journals Orange Fluorescent Proteins: Filling the Spectral Gap

2014 ◽  
Vol 70 (a1) ◽  
pp. C1670-C1670
Author(s):  
Sergei Pletnev ◽  
Daria Shcherbakova ◽  
Oksana Subach ◽  
Vladimir Malashkevich ◽  
Steven Almo ◽  
...  
Keyword(s):  
In Vivo Imaging ◽  
Spectral Properties ◽  
Molecular Mechanisms ◽  
Fluorescent Protein ◽  
Fluorescent Proteins ◽  
Stokes Shift ◽  
Emission Wavelength ◽  
Microscopy Imaging ◽  
Large Stokes Shift

Fluorescent proteins (FPs) have become valuable tools for molecular biology, biochemistry, medicine, and cancer research. Starting from parent green fluorescent protein (GFP), most challenging task of the FPs studies was the development of FPs with longer excitation/emission wavelength. This pursuit was motivated by advantages of so-called red-shifted FPs, namely, lower background of cellular autofluorescence in microscopy, lower light scattering and reduced tissue absorbance of longer wavelengths for in vivo imaging. In addition to FPs with regular spectral properties, there are proteins of other types available, including FPs with a large Stokes shift and photoconvertible FPs. These special kinds of FPs have become useful in super-resolution microscopy, imaging of enzyme activities, protein-protein interactions, photolabeling, and in vivo imaging. According to their emission wavelength, red-shifted FPs could be divided in the following groups: 520-540 nm yellow FPs (YFPs), 540-570 nm orange FPs (OFPs), 570-620 nm red FPs (RFPs), and > 620 nm far-RFPs. Red shift of the excitation/emission bands of these FPs is predominantly achieved by extension of the conjugated system of the chromophore and its protonation/deprotonation. The variety of spectral properties of FPs (excitation and emission wavelength, quantum yield, brightness, photo- and pH- stability, photoconversion, large Stokes shift, etc) results from the different chromophore structures and its interactions with surrounding amino acid residues. In this work we focus on structural studies and molecular mechanisms of FPs with orange emission.

scholarly journals Nanobioimaging: Intrinsically Fluorescent, Stealth Polypyrazoline Nanoparticles with Large Stokes Shift for In Vivo Imaging (Small 36/2018)

Small ◽  
2018 ◽  
Vol 14 (36) ◽  
pp. 1870162
Author(s):  
Shivshankar R. Mane ◽  
I-Lun Hsiao ◽  
Masanari Takamiya ◽  
Dao Le ◽  
Uwe Straehle ◽  
...  
Keyword(s):  
In Vivo Imaging ◽  
Stokes Shift ◽  
Large Stokes Shift

scholarly journals Intrinsically Fluorescent, Stealth Polypyrazoline Nanoparticles with Large Stokes Shift for In Vivo Imaging

Small ◽  
2018 ◽  
Vol 14 (36) ◽  
pp. 1801571 ◽  
Author(s):  
Shivshankar R. Mane ◽  
I-Lun Hsiao ◽  
Masanari Takamiya ◽  
Dao Le ◽  
Uwe Straehle ◽  
...  
Keyword(s):  
In Vivo Imaging ◽  
Stokes Shift ◽  
Large Stokes Shift

scholarly journals Synthesis and properties of lysosome-specific photoactivatable probes for live-cell imaging

2015 ◽  
Vol 6 (8) ◽  
pp. 4508-4512 ◽  
Author(s):  
Mai N. Tran ◽  
Robert-André F. Rarig ◽  
David M. Chenoweth
Keyword(s):  
Live Cell Imaging ◽  
Cell Imaging ◽  
Stokes Shift ◽  
Live Cell ◽  
Large Stokes Shift ◽  
New Class

We describe the synthesis and application of a new class of large Stokes shift lysosome-specific photoactivatable probes for live-cell imaging.

A NIR fluorescence probe having significant fluorescence turn-on signal at 700 nm and large Stokes shift for rapid detection of HOCl in vivo

Talanta ◽  
2021 ◽  
Vol 223 ◽  
pp. 121768
Author(s):  
Haiyan Zhang ◽  
Xinyu Yin ◽  
Jiaxin Hong ◽  
Yingzhen Deng ◽  
Guoqiang Feng
Keyword(s):  
Rapid Detection ◽  
Fluorescence Probe ◽  
Stokes Shift ◽  
Large Stokes Shift ◽  
Turn On ◽  
Nir Fluorescence ◽  
Fluorescence Turn On

Theoretical Insight into the Origin of Large Stokes Shift and Photophysical Properties of Anilido-Pyridine Boron Difluoride Dyes

ChemPhysChem ◽  
2012 ◽  
Vol 13 (16) ◽  
pp. 3714-3722 ◽  
Author(s):  
Jun-Ling Jin ◽  
Hai-Bin Li ◽  
Yun Geng ◽  
Yong Wu ◽  
Yu-Ai Duan ◽  
...  
Keyword(s):  
Photophysical Properties ◽  
Stokes Shift ◽  
Large Stokes Shift ◽  
Boron Difluoride ◽  
Theoretical Insight ◽  
Insight Into
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