scholarly journals The longer the worse: a combined proteomic and targeted study of the long-term versus short-term effects of silver nanoparticles on macrophages

2020 ◽  
Vol 7 (7) ◽  
pp. 2032-2046
Author(s):  
Bastien Dalzon ◽  
Catherine Aude-Garcia ◽  
Hélène Diemer ◽  
Joanna Bons ◽  
Caroline Marie-Desvergne ◽  
...  
Keyword(s):  
Silver Nanoparticles ◽  
Chronic Exposure ◽  
Acute Exposure ◽  
Short Term ◽  
Short Term Effects

At equal cumulated dose, a chronic exposure to silver nanoparticles produces more effects on macrophages than an acute exposure.

scholarly journals Acute and chronic exposure to air pollution in relation with incidence, prevalence, severity and mortality of COVID-19: a rapid systematic review

2021 ◽  
Vol 20 (1) ◽  
Author(s):  
Patrick D. M. C. Katoto ◽  
Amanda S. Brand ◽  
Buket Bakan ◽  
Paul Musa Obadia ◽  
Carsi Kuhangana ◽  
...  
Keyword(s):  
Air Pollution ◽  
Chronic Exposure ◽  
Ambient Air ◽  
Short Term ◽  
Incidence And Mortality ◽  
Acute And Chronic Exposure ◽  
Anthropogenic Pollutant ◽  
Incident Cases ◽  
Incidence Prevalence

Abstract Background Air pollution is one of the world’s leading mortality risk factors contributing to seven million deaths annually. COVID-19 pandemic has claimed about one million deaths in less than a year. However, it is unclear whether exposure to acute and chronic air pollution influences the COVID-19 epidemiologic curve. Methods We searched for relevant studies listed in six electronic databases between December 2019 and September 2020. We applied no language or publication status limits. Studies presented as original articles, studies that assessed risk, incidence, prevalence, or lethality of COVID-19 in relation with exposure to either short-term or long-term exposure to ambient air pollution were included. All patients regardless of age, sex and location diagnosed as having COVID-19 of any severity were taken into consideration. We synthesised results using harvest plots based on effect direction. Results Included studies were cross-sectional (n = 10), retrospective cohorts (n = 9), ecological (n = 6 of which two were time-series) and hypothesis (n = 1). Of these studies, 52 and 48% assessed the effect of short-term and long-term pollutant exposure, respectively and one evaluated both. Pollutants mostly studied were PM2.5 (64%), NO2 (50%), PM10 (43%) and O3 (29%) for acute effects and PM2.5 (85%), NO2 (39%) and O3 (23%) then PM10 (15%) for chronic effects. Most assessed COVID-19 outcomes were incidence and mortality rate. Acutely, pollutants independently associated with COVID-19 incidence and mortality were first PM2.5 then PM10, NO2 and O3 (only for incident cases). Chronically, similar relationships were found for PM2.5 and NO2. High overall risk of bias judgments (86 and 39% in short-term and long-term exposure studies, respectively) was predominantly due to a failure to adjust aggregated data for important confounders, and to a lesser extent because of a lack of comparative analysis. Conclusion The body of evidence indicates that both acute and chronic exposure to air pollution can affect COVID-19 epidemiology. The evidence is unclear for acute exposure due to a higher level of bias in existing studies as compared to moderate evidence with chronic exposure. Public health interventions that help minimize anthropogenic pollutant source and socio-economic injustice/disparities may reduce the planetary threat posed by both COVID-19 and air pollution pandemics.

scholarly journals Metabolic plasticity can amplify ecosystem responses to global warming

2021 ◽  
Author(s):  
Rebecca Kordas ◽  
Samraat Pawar ◽  
Guy Woodward ◽  
Eoin O'Gorman
Keyword(s):  
Global Warming ◽  
Body Size ◽  
Predictive Models ◽  
Chronic Exposure ◽  
Ecosystem Respiration ◽  
Short Term ◽  
Ecosystem Responses ◽  
Metabolic Plasticity ◽  
Ecosystem Level

Abstract Organisms have the capacity to alter their physiological response to warming through acclimation or adaptation, but empirical evidence for this metabolic plasticity across species within food webs is lacking, and a generalisable framework does not exist for modelling its ecosystem-level consequences. Here we show that the ability of organisms to raise their metabolic rate following chronic exposure to warming decreases with increasing body size. Chronic exposure to higher temperatures also increases the sensitivity of organisms to short-term warming, irrespective of their body size. A mathematical model parameterised with these findings shows that metabolic plasticity could account for an additional 60% of ecosystem energy flux with just +2 °C of warming. This could explain why ecosystem respiration continues to rise in long-term warming experiments and highlights the need to embed metabolic plasticity in predictive models of global warming impacts on ecosystems.

Short-term cell volume regulation in Mytilus californianus gill.

1994 ◽  
Vol 194 (1) ◽  
pp. 47-68
Author(s):  
A L Silva ◽  
S H Wright
Keyword(s):  
Cell Volume ◽  
Sea Water ◽  
Optical Measurement ◽  
Regulatory Volume Decrease ◽  
Cell Volume Regulation ◽  
Acute Exposure ◽  
Mytilus Californianus ◽  
K Channel ◽  
Short Term

Long-term acclimation of Mytilus californianus to 60% artificial sea water (585 mosmol l-1; ASW) led to a 30-40% decrease in the taurine (53.5-36.9 mumol g-1 wet mass) and betaine (44.8-26.2 mumol g-1 wet mass) content of gill tissue, compared with that of control animals held in 100% ASW (980 mosmol l-1). The K+ content of gills did not change following long-term acclimation to reduced salinity. In contrast, losses of all three solutes during a brief (60 min) exposure to 60% ASW were less than or equal to 15%. Nevertheless, the swelling of gill cells that occurred after acute exposure to 60% ASW was followed by a return towards the control volume. Direct optical measurement of single gill filaments confirmed that, during an acute exposure to reduced salinity, ciliated lateral cells increased in cell height (volume) and then underwent a regulatory volume decrease (RVD) with a half-time of approximately 10 min. This short-term RVD was completely inhibited by exposure to 1 mmol l-1 quinidine, a K+ channel blocker, but only when the drug was applied to the basolateral aspect of the gill epithelium. Application of 1 mumol l-1 valinomycin relieved the inhibition by quinidine of the gill RVD. However, addition of valinomycin did not accelerate the rate of RVD observed in the absence of quinidine. These results indicate that long-term acclimation of Mytilus californianus gill in dilute sea water involves primarily losses of taurine and betaine, whereas short-term regulation of cell volume may involve an electrically conductive loss of intracellular K+ and a counter ion.

Application of Skills to Procrastination (optional)

2017 ◽  
pp. 109-118
Author(s):  
Steven A. Safren ◽  
Susan E. Sprich ◽  
Carol A. Perlman ◽  
Michael W. Otto
Keyword(s):  
Problem Solving ◽  
Cognitive Restructuring ◽  
Case Vignette ◽  
Negative Consequences ◽  
Short Term ◽  
Pros And Cons ◽  
Short Term Effects

This chapter outlines an optional session for clients with ADHD that focuses on procrastination. It describes how the therapist can discuss the attractive aspects of procrastination and how the client can learn to identify the negative consequences of procrastination. An exercise is presented where the client goes over the pros and cons of procrastination using a specific example. The chapter includes a discussion of how previously taught skills of problem-solving, adaptive thinking, and cognitive restructuring can be applied to procrastination. A case vignette illustrates the process of identifying the long-term and short-term effects of procrastination.

Retirement and Mortality

1980 ◽  
Vol 8 (1) ◽  
pp. 39-41 ◽  
Author(s):  
Timo Niemi
Keyword(s):  
Old Age ◽  
Short Term ◽  
Stress Situation ◽  
Short Term Effects

The present study investigated the effects of retirement on the mortality of the retired. The basis of retirement for the present subjects was in all cases age, not sickness. The subjects were 1 176 men retired on old age pension. In the present study, retirement could not be shown to have any long-term or short-term effects on mortality pointing to retirement not being such a stress situation as to result in an increase in mortality.

scholarly journals Short- and Long-Term Effects of Nonconsciously Processed Ambient Scents in a Servicescape: Findings From Two Field Experiments

2019 ◽  
Vol 22 (4) ◽  
pp. 440-455 ◽  
Author(s):  
Anna Girard ◽  
Marcel Lichters ◽  
Marko Sarstedt ◽  
Dipayan Biswas
Keyword(s):  
Large Scale ◽  
Field Experiments ◽  
Field Studies ◽  
Long Term Effects ◽  
Short Term ◽  
Railway Company ◽  
Short And Long Term ◽  
Ambient Scents ◽  
Short Term Effects

Ambient scents are being increasingly used in different service environments. While there is emerging research on the effects of scents, almost nothing is known about the long-term effects of consumers’ repeated exposure to ambient scents in a service environment as prior studies on ambient scents have been lab or field studies examining short-term effects of scent exposure only. Addressing this limitation, we examine the short- and long-term effects of ambient scents. Specifically, we present a conceptual framework for the short- and long-term effects of nonconsciously processed ambient scent in olfactory-rich servicescapes. We empirically test this framework with the help of two large-scale field experiments, conducted in collaboration with a major German railway company, in which consumers were exposed to a pleasant, nonconsciously processed scent. The first experiment demonstrates ambient scent’s positive short-term effects on consumers’ service perceptions. The second experiment—a longitudinal study conducted over a 4-month period—examines scent’s long-term effects on consumers’ reactions and demonstrates that the effects persist even when the scent has been removed from the servicescape.

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