Acetic acid mediated regioselective synthesis of 2,4,5-trisubstituted thiazoles by a domino multicomponent reaction

2019 ◽  
Vol 43 (22) ◽  
pp. 8644-8650 ◽  
Author(s):  
Mohit Saroha ◽  
Jitender M. Khurana
Keyword(s):  
Acetic Acid ◽  
Multicomponent Reaction ◽  
Regioselective Synthesis ◽  
Domino Reaction ◽  
Thiazole Derivatives ◽  
Active Methylene

Acetic acid mediated regioselective synthesis of novel 2,4,5-trisubstituted thiazole derivatives has been reported by a domino reaction of thiosemicarbazide and aldehydes/ketones/isatin, to generate thiosemicarbazones (in situ) followed by addition of arylglyoxal and active methylene/activated C–H acids/pyrazole/indole in ethanol at 80 °C.

scholarly journals Microwave-Assisted Synthesis of Tetrahydrocarbazole Linked 1,2-Diazoles in Aqueous-Brønsted Acid Catalytic System

2017 ◽  
Vol 2017 ◽  
pp. 1-17 ◽  
Author(s):  
Zubi Sadiq ◽  
Erum Akbar Hussain ◽  
Narjis Naz ◽  
Ambreen Ghani ◽  
Kausar Yasmeen ◽  
...  
Keyword(s):  
Acetic Acid ◽  
Catalytic System ◽  
Multicomponent Reaction ◽  
Conventional Heating ◽  
Microwave Assisted Synthesis ◽  
Spectroscopic Techniques ◽  
Unsaturated Ketones ◽  
Microwave Assisted ◽  
Michael Type Addition

A new series of tetrahydrocarbazole coupled 1,2-diazoles 4/5/6(a–o) in moderate to excellent yield was synthesized successfully via multicomponent reaction approach by adopting Michael type-addition of hydrazines on in situ generated α,β-unsaturated ketones via aldol type strategy under synthetic microwave radiations and conventional heating. Structural confirmations of all the prepared compounds were achieved by spectroscopic techniques. The best results were achieved when equal amounts of water-acetic acid were used in microwave conditions in 4 minutes.

ChemInform Abstract: A Three-Component Domino Reaction of 2-Tetralone, Hydroxylamine and Acetylene: A One-Pot, Highly Regioselective Synthesis of 4,5-Dihydrobenz[e]indoles.

ChemInform ◽  
2010 ◽  
Vol 41 (28) ◽  
pp. no-no
Author(s):  
Alexander M. Vasil'tsov ◽  
Andrei V. Ivanov ◽  
Al'bina I. Mikhaleva ◽  
Boris A. Trofimov
Keyword(s):  
Regioselective Synthesis ◽  
Domino Reaction ◽  
One Pot

Molecular diversity of the acid promoted domino reaction of 3-hydroxy-3-(indol-3-yl)indolin-2-ones and cyclic mercapto-substituted β-enamino esters

2021 ◽  
Author(s):  
Liu-Na Pan ◽  
Qing Wang ◽  
Jing Sun ◽  
Quan-Shun Sun ◽  
Chao-Guo Yan
Keyword(s):  
Acetic Acid ◽  
Molecular Diversity ◽  
Domino Reaction

The acetic acid promoted reaction of 3-hydroxy-3-(indol-3-yl)indolin-2-ones and mercapto-substituted β-enamino esters showed very interesting molecular diversity.

Development of novel sourdoughs with in situ formed exopolysaccharides from acetic acid bacteria

2015 ◽  
Vol 241 (2) ◽  
pp. 185-197 ◽  
Author(s):  
Maria Hermann ◽  
Hannes Petermeier ◽  
Rudi F. Vogel
Keyword(s):  
Acetic Acid ◽  
Acetic Acid Bacteria

Iodine-mediated C–N and C–S bond formation: regioselective synthesis of benzo[4,5]imidazo[2,1-b]thiazoles

2017 ◽  
Vol 41 (1) ◽  
pp. 75-80 ◽  
Author(s):  
Sethurajan Ambethkar ◽  
Muthalu Vellimalai ◽  
Vediappen Padmini ◽  
Nattamai Bhuvanesh
Keyword(s):  
Reaction Time ◽  
Intramolecular Cyclization ◽  
Simple Procedure ◽  
Bond Formation ◽  
Molecular Iodine ◽  
Regioselective Synthesis ◽  
Thiazole Derivatives ◽  
Short Reaction Time ◽  
Metal Free

The regioselective synthesis of benzo[4,5]imidazo[2,1-b]thiazole derivatives via amination (C–N) and intramolecular cyclization (C–S) reactions in the presence of molecular iodine has been reported. This method is base and metal free and features inexpensive catalysts, with a simple procedure and a short reaction time.

Instabilities in the System NMMO/Water/Cellulose (Lyocell Process) Caused by Polonowski Type Reactions

Holzforschung ◽  
2002 ◽  
Vol 56 (2) ◽  
pp. 199-208 ◽  
Author(s):  
Thomas Rosenau ◽  
Antje Potthast ◽  
Andreas Hofinger ◽  
Herbert Sixta ◽  
Paul Kosma
Keyword(s):  
Molecular Weight ◽  
Acetic Acid ◽  
Exchange Resin ◽  
Degradation Products ◽  
Ion Exchange Resin ◽  
Low Molecular Weight ◽  
Acid Component ◽  
Degradation Reactions ◽  
Polyglucuronic Acid

Summary Polonowski type degradation reactions are a major reason for the frequently observed instability of solutions of cellulose in N-methylmorpholine-N-oxide monohydrate (NMMO, 1). The degradation is induced by degradation products of cellulose and NMMO generated in situ in the Lyocell system. The presence of both an amine component, such as morpholine or N-methylmorpholine, and an acid component is required for the decomposition process to proceed. The latter might be a low-molecular-weight compound, such as formic acid, acetic acid or gluconic acid, or also a high-molecular-weight acid, such as polyglucuronic acid or ion exchange resin.

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