Autophagic stress; a new cellular response to nanoparticles. Could it be a new strategy for inhibition of liver cancer cell invasion and metastasis?

Nanoscale ◽  
2020 ◽  
Vol 12 (11) ◽  
pp. 6556-6561 ◽  
Author(s):  
Chalermchai Pilapong ◽  
Thipjutha Phatruengdet ◽  
Saowalak Krungchanuchat
Keyword(s):  
Liver Cancer ◽  
Cancer Cell ◽  
Cell Invasion ◽  
Cellular Response ◽  
Migration And Invasion ◽  
Cancer Cell Migration ◽  
Liver Cancer Cell ◽  
Cancer Cell Invasion ◽  
Invasion And Metastasis ◽  
New Strategy

The autophagic stress induced by Fe–TA NPs is capable of reducing liver cancer cell migration and invasion. This would be a new tactic to treat liver cancer.

scholarly journals Chinese herbal formula QHF inhibits liver cancer cell invasion and migration

2016 ◽  
Vol 11 (6) ◽  
pp. 2413-2419 ◽  
Author(s):  
TAO CHEN ◽  
QUAN WANG ◽  
YUNXIAO LI ◽  
HEFEI HUANG ◽  
WEI HU
Keyword(s):  
Liver Cancer ◽  
Cancer Cell ◽  
Cell Invasion ◽  
Herbal Formula ◽  
Liver Cancer Cell ◽  
Cancer Cell Invasion ◽  
Invasion And Migration ◽  
Chinese Herbal Formula ◽  
Chinese Herbal ◽  
And Migration

scholarly journals Effect on the liver cancer cell invasion ability by studying the associations between autophagy and TRAP1 expression

2018 ◽  
Author(s):  
Yi Sun ◽  
Hongling Zou ◽  
Liu Yang ◽  
Mengting Zhou ◽  
Xiaoling Shi ◽  
...  
Keyword(s):  
Liver Cancer ◽  
Cancer Cell ◽  
Cell Invasion ◽  
Liver Cancer Cell ◽  
Cancer Cell Invasion

scholarly journals α‑enolase is highly expressed in liver cancer and promotes cancer cell invasion and metastasis

2020 ◽  
Vol 20 (5) ◽  
pp. 1-1
Author(s):  
Lihong Zhang ◽  
Tao Lu ◽  
Ye Yang ◽  
Liangfeng Hu
Keyword(s):  
Liver Cancer ◽  
Cancer Cell ◽  
Cell Invasion ◽  
Cancer Cell Invasion ◽  
Invasion And Metastasis

scholarly journals Inhibition of human liver cancer cell growth by evodiamine involves apoptosis and deactivation of PI3K/AKT pathway

2020 ◽  
Vol 63 (1) ◽  
Author(s):  
Jia Jia ◽  
Xigang Kang ◽  
Yanfang Liu ◽  
Jianwei Zhang
Keyword(s):  
Liver Cancer ◽  
Cancer Cell ◽  
Human Liver ◽  
Akt Pathway ◽  
Migration And Invasion ◽  
Dependent Manner ◽  
Liver Cancer Cell ◽  
Human Liver Cancer Cell ◽  
Human Liver Cancer ◽  
Induction Of Apoptosis

Abstract Evodiamine is an active alkaloid member found in Traditional Chinese Herb (TCH) Evodia rutaecarpa. It has been reported to exhibit remarkable biological and medicinal activities including anticancer and anti-inflammatory. This study was designed to investigate the anticancer effects of evodiamine against human liver cancer and evaluate its effects on cell migration, cell invasion, cellular apoptosis and PI3K/AKT pathway. The results showed that evodiamine exhibits potent antiproliferative effects against two human liver cancer cell lines (HepG2 and PLHC-1) with an IC50 of 20 µM. Nonetheless, the cytotoxic effects of evodiamine were comparatively low against the normal cells as evident from the IC50 of 100 μM. The growth inhibitory effects of evodiamine were found to be due to the induction of apoptosis as revealed by the DAPI, AO/EB and annexin V/PI staining assays. The induction of apoptosis was also associated with upregulation of Bax and downregulation of Bcl-2 expression in a concentration dependent manner. The wound healing and transwell assay revealed that evodiamine caused a significant decline in the migration and invasion of the HepG2 and PLHC-1 cells. Investigation of the effects of evodiamine on the PI3K/AKT signalling revealed that evodiamine inhibited the phosphorylation of PI3K and AKT proteins. Taken together, the results showed that evodiamine inhibits the growth of human liver cancer via induction of apoptosis and deactivation of PI3K/AKT pathway. The results point towards the therapeutic potential of evodiamine in the treatment of liver cancer.

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