Sox2 expression predicts poor survival of hepatocellular carcinoma patients and it promotes liver cancer cell invasion by activating Slug

2013 ◽  
Vol 30 (2) ◽  
Author(s):  
Chun Sun ◽  
Lu Sun ◽  
Yan Li ◽  
Xiaonan Kang ◽  
Shu Zhang ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Cancer ◽  
Cancer Cell ◽  
Cell Invasion ◽  
Liver Cancer Cell ◽  
Cancer Cell Invasion ◽  
Poor Survival ◽  
Sox2 Expression

Autophagic stress; a new cellular response to nanoparticles. Could it be a new strategy for inhibition of liver cancer cell invasion and metastasis?

Nanoscale ◽  
2020 ◽  
Vol 12 (11) ◽  
pp. 6556-6561 ◽  
Author(s):  
Chalermchai Pilapong ◽  
Thipjutha Phatruengdet ◽  
Saowalak Krungchanuchat
Keyword(s):  
Liver Cancer ◽  
Cancer Cell ◽  
Cell Invasion ◽  
Cellular Response ◽  
Migration And Invasion ◽  
Cancer Cell Migration ◽  
Liver Cancer Cell ◽  
Cancer Cell Invasion ◽  
Invasion And Metastasis ◽  
New Strategy

The autophagic stress induced by Fe–TA NPs is capable of reducing liver cancer cell migration and invasion. This would be a new tactic to treat liver cancer.

scholarly journals Chinese herbal formula QHF inhibits liver cancer cell invasion and migration

2016 ◽  
Vol 11 (6) ◽  
pp. 2413-2419 ◽  
Author(s):  
TAO CHEN ◽  
QUAN WANG ◽  
YUNXIAO LI ◽  
HEFEI HUANG ◽  
WEI HU
Keyword(s):  
Liver Cancer ◽  
Cancer Cell ◽  
Cell Invasion ◽  
Herbal Formula ◽  
Liver Cancer Cell ◽  
Cancer Cell Invasion ◽  
Invasion And Migration ◽  
Chinese Herbal Formula ◽  
Chinese Herbal ◽  
And Migration

scholarly journals Effect on the liver cancer cell invasion ability by studying the associations between autophagy and TRAP1 expression

2018 ◽  
Author(s):  
Yi Sun ◽  
Hongling Zou ◽  
Liu Yang ◽  
Mengting Zhou ◽  
Xiaoling Shi ◽  
...  
Keyword(s):  
Liver Cancer ◽  
Cancer Cell ◽  
Cell Invasion ◽  
Liver Cancer Cell ◽  
Cancer Cell Invasion

scholarly journals Anti-Proliferative Effects of an Extra-Virgin Olive Oil Extract Enriched in Ligstroside Aglycone and Oleocanthal on Human Liver Cancer Cell Lines

Cancers ◽  
2019 ◽  
Vol 11 (11) ◽  
pp. 1640 ◽  
Author(s):  
De Stefanis ◽  
Scimè ◽  
Accomazzo ◽  
Catti ◽  
Occhipinti ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Cancer ◽  
Olive Oil ◽  
Cell Lines ◽  
Cancer Cell ◽  
Virgin Olive Oil ◽  
Cancer Cell Lines ◽  
Liver Cancer Cell ◽  
Antioxidant Power ◽  
Polyphenolic Extract

Oleocanthal and ligstroside aglycone are olive oil-derived polyphenols. The former interferes with tumor growth with minor or no cytotoxicity on non-tumorigenic primary cell lines. The information about the bioactivity of ligstroside aglycone are scanty, with the exception of a known antioxidant power. Hepatocellular carcinoma is a malignant tumor with high mortality rates. Systemic chemotherapy is only marginally effective and is frequently complicated by toxicity. Previous observations have shown that hepatocellular carcinoma cell lines become more sensitive to taxol when it is combined with Tumor Necrosis Factor α (TNFα). The present work aimed to assess the effects of a polyphenolic extract containing both oleocanthal and ligstroside aglycone on proliferation and/or death in three liver cancer cell lines (HepG2, Huh7 and Hep3B). The possibility to enhance such effect by the addition of TNFα was also investigated. Both cell proliferation and death were enhanced by the exposure to the polyphenolic extract. Such effect was associated with induction of autophagy and could be potentiated by TNFα. The presence of ligstroside aglycone in the extract lowered the oleocanthal concentration required for cytotoxicity. These results show for the first time that the effects of a polyphenol extract can be potentiated by TNFα and that modulation of autophagy likely account for these effects.

scholarly journals Analysis of Liver Cancer Cell Lines Identifies Agents With Likely Efficacy Against Hepatocellular Carcinoma and Markers of Response

2019 ◽  
Vol 157 (3) ◽  
pp. 760-776 ◽  
Author(s):  
Stefano Caruso ◽  
Anna-Line Calatayud ◽  
Jill Pilet ◽  
Tiziana La Bella ◽  
Samia Rekik ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Cancer ◽  
Cell Lines ◽  
Cancer Cell ◽  
Cancer Cell Lines ◽  
Liver Cancer Cell

scholarly journals Cooperative Role of Thrombopoietin and Vascular Endothelial Growth Factor-A in the Progression of Liver Cirrhosis to Hepatocellular Carcinoma

2021 ◽  
Vol 22 (4) ◽  
pp. 1818
Author(s):  
Barbara Vizio ◽  
Ornella Bosco ◽  
Ezio David ◽  
Gian Paolo Caviglia ◽  
Maria Lorena Abate ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Vascular Endothelial Growth Factor ◽  
Liver Cirrhosis ◽  
Growth Factor ◽  
Liver Cancer ◽  
Cell Lines ◽  
Cancer Cell ◽  
Vascular Endothelial ◽  
Liver Cancer Cell ◽  
Endothelial Growth Factor

Primary thrombopoietic mediator thrombopoietin (THPO) is mainly produced by the liver; it may act as a growth factor for hepatic progenitors. Principal angiogenesis inducer vascular endothelial growth factor-A (VEGF-A) is critical for the complex vascular network within the liver architecture. As a cross-regulatory loop between THPO and VEGF-A has been demonstrated in the hematopoietic system, the two growth factors were hypothesized to cooperatively contribute to the progression from liver cirrhosis (LC) to hepatocellular carcinoma (HCC). The mRNA and protein expression levels of THPO, VEGF-A, and their receptors were examined, compared, and correlated in paired cancerous and LC tissues from 26 cirrhosis-related HCC patients, using qRT-PCR and immunohistochemistry. THPO and VEGF-A were alternatively silenced by small interfering RNA (siRNA) in human liver cancer cell lines Huh7 and HepG2. THPO and VEGF-A expressions significantly increased in tumor versus LC tissues. HCC and paired LC cells expressed similar levels of THPO receptor (R), whereas vascular endothelial growth factor receptor (VEGFR) -1 and VEGFR-2 levels were higher in HCC than in corresponding LC tissue samples. A significant linear correlation emerged between THPO and VEGF-A transcripts in HCC and, at the protein level, THPO and THPOR were significantly correlated with VEGF-A in tumor tissues. Both HCC and LC expressed similar levels of gene and protein hypoxia inducible factor (HIF)-1α. Positive cross-regulation occurred with the alternative administration of siRNAs targeting THPO and those targeting VEGF-A in hypoxic liver cancer cell lines. These results suggest THPO and VEGF-A might act as interdependently regulated autocrine and/or paracrine systems for cellular growth in HCC. This might be clinically interesting, since new classes of THPOR agonistic/antagonistic drugs may provide novel therapeutic options to correct the frequent hemostatic abnormality seen in HCC patients.

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