scholarly journals Drug Delivery: Dimeric Drug Polymeric Micelles with Acid‐Active Tumor Targeting and FRET‐Traceable Drug Release (Adv. Mater. 3/2018)

2018 ◽  
Vol 30 (3) ◽  
pp. 1870020 ◽  
Author(s):  
Xing Guo ◽  
Lin Wang ◽  
Kayla Duval ◽  
Jing Fan ◽  
Shaobing Zhou ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Tumor Targeting ◽  
Polymeric Micelles

Tumor-targeting intracellular drug delivery based on dual acid/reduction-degradable nanoassemblies with ketal interface and disulfide core locations

2019 ◽  
Vol 10 (22) ◽  
pp. 2840-2853 ◽  
Author(s):  
Arman Moini Jazani ◽  
Newsha Arezi ◽  
Chaitra Shetty ◽  
Sung Hwa Hong ◽  
Haowen Li ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Block Copolymer ◽  
Drug Release ◽  
Tumor Targeting ◽  
Intracellular Drug Delivery ◽  
Acid Reduction

Dual acid/reduction-degradable block copolymer nanoassemblies both at core/corona interfaces and in micellar cores leading to synergistic and accelerated drug release for robust tumor-targeting intracellular drug delivery.

A multifunctional PEG–PLL drug conjugate forming redox-responsive nanoparticles for intracellular drug delivery

2015 ◽  
Vol 3 (38) ◽  
pp. 7594-7603 ◽  
Author(s):  
Zhuxian Zhou ◽  
Jianbin Tang ◽  
Qihang Sun ◽  
William J. Murdoch ◽  
Youqing Shen
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Tumor Targeting ◽  
High Stability ◽  
Cancer Targeting ◽  
Drug Conjugate ◽  
Intracellular Drug Delivery ◽  
Redox Responsive ◽  
Triggered Drug Release

Tumor-targeting camptothecin (CPT)-conjugated nanoparticles with high stability and GSH-triggered drug release were developed for cancer targeting drug delivery.

Biodegradable poly(ethylene glycol)–poly(ε-carprolactone) polymeric micelles with different tailored topological amphiphilies for doxorubicin (DOX) drug delivery

RSC Advances ◽  
2016 ◽  
Vol 6 (63) ◽  
pp. 58160-58172 ◽  
Author(s):  
Y. Chen ◽  
Y. X. Zhang ◽  
Z. F. Wu ◽  
X. Y. Peng ◽  
T. Su ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Ethylene Glycol ◽  
Self Assembly ◽  
Polymeric Micelles ◽  
The Self ◽  
Molar Ratio ◽  
Poly Ethylene Glycol ◽  
Biodegradable Poly ◽  
Poly Ethylene

The self-assembly and drug release of the three PEG–PCL copolymers with different topologies but identical molar ratio between PEG to PCL.

Fabrication of Mixed Polymeric Micelles Based on Stimuli-Responsive Amphiphilic Copolymers for Drug Delivery and Controlled Release

NANO ◽  
2020 ◽  
Vol 15 (03) ◽  
pp. 2050040 ◽  
Author(s):  
Jia Liu ◽  
Juan Li ◽  
Tingting Liu
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Block Copolymers ◽  
Drug Release ◽  
Ethylene Glycol ◽  
Polymeric Micelles ◽  
Poly Ethylene Glycol ◽  
Mixed Polymeric Micelles ◽  
Poly Ethylene ◽  
Glycol Methyl Ether

In this report, mixed polymeric micelles (MPMs) system self-assembled from two kinds of cholesterol-grafted amphiphilic block copolymers cholesterol modified poly ([Formula: see text]-amino esters)-grafted disulfide poly (ethylene glycol) methyl ether (PAE(-ss-mPEG)-[Formula: see text]-Chol) and poly([Formula: see text]-amino ester)-g-poly(ethylene glycol) methyl ether-cholesterol (PAE-[Formula: see text]-mPEG-Chol) were prepared for drug delivery and controlled release with pH and redox-responsibilities. The self-assembly of two block copolymers was evaluated by measurement of critical micelle concentration (CMC) values using fluorescence spectroscopy. The hydrodynamic diameter, polydispersity index (PDI) and zeta-potential of MPMs in aqueous were recorded by dynamic light scattering (DLS) at different conditions. Doxorubicin (DOX) was efficiently encapsulated in the micellar core by the hydrophobic interaction. The drug loading content (LC) and encapsulation efficacy (EE) of MPMs with different formulations were evaluated. The DOX was released due to the swelling and disassembly of MPMs induced by low pH and high glutathione (GSH) concentrations. The in vitro results demonstrated that drug release rate and cumulative release were obviously dependent on pH values and reducing agents. The results showed that the MPMs could be the potential anticancer drug delivery carriers with pH/redox-triggered drug release profile.

scholarly journals Spermine modified polymeric micelles with pH-sensitive drug release for targeted and enhanced antitumor therapy

RSC Advances ◽  
2019 ◽  
Vol 9 (20) ◽  
pp. 11026-11037 ◽  
Author(s):  
Yang Chen ◽  
Cejun Yang ◽  
Juan Mao ◽  
Haigang Li ◽  
Jinsong Ding ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Drug Release ◽  
Tumor Targeting ◽  
Polymeric Micelles ◽  
Ph Sensitive ◽  
Antitumor Therapy ◽  
Anti Cancer ◽  
Targeting Delivery

Tumor targeting delivery of SPM functionalized micelles via PTS binding and their endocytosis and pH-triggered endo/lysosome drug release for anti-cancer therapy.

Advances in polymeric micelles for drug delivery and tumor targeting

2010 ◽  
Vol 6 (6) ◽  
pp. 714-729 ◽  
Author(s):  
Uttam Kedar ◽  
Prasanna Phutane ◽  
Supriya Shidhaye ◽  
Vilasrao Kadam
Keyword(s):  
Drug Delivery ◽  
Tumor Targeting ◽  
Polymeric Micelles

scholarly journals A comprehensive review on polymeric micelles: a promising drug delivery carrier

2021 ◽  
Vol 10 (3) ◽  
pp. 102-107
Author(s):  
Ajay Kumar
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Drug Delivery Systems ◽  
Polymeric Micelles ◽  
Delivery Systems ◽  
Hydrophobic Drug ◽  
Drug Release Profile ◽  
Physiological Conditions ◽  
Drug Molecules ◽  
Drug Delivery Carrier

The main aim of drug delivery systems is to regulate the rate of drug release as per the patient's physiological conditions as well as the progression of the illness or as per the circadian rhythms. To achieve such objectives, the new drug delivery systems have been developed to provide the drug release profile, which is based on each patient's needs. Different researches have been done to create drug delivery carriers, focusing on targeting and delivering hydrophobic drug molecules. This review focuses on Polymeric Micelles as the promising drug delivery carrier due to its high stability, protective property against the harsh gastrointestinal environment.

scholarly journals Oseltamivir-conjugated polymeric micelles prepared by RAFT living radical polymerization as a new active tumor targeting drug delivery platform

2016 ◽  
Vol 4 (3) ◽  
pp. 511-521 ◽  
Author(s):  
Vitaliy Kapishon ◽  
Stephanie Allison ◽  
Ralph A. Whitney ◽  
Michael F. Cunningham ◽  
Myron R. Szewczuk ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Cells ◽  
Radical Polymerization ◽  
Tumor Targeting ◽  
Polymeric Micelles ◽  
Living Radical Polymerization ◽  
Delivery Platform

Synthetic steps and subsequent preparation of oseltamivir-conjugated micelles capable of targeting and triggering receptor-induced endocytosis in cancer cells.

Nanomized tumor-microenvironment-active NIR fluorescent prodrug for ensuring synchronous occurrences of drug release and fluorescence tracing

2019 ◽  
Vol 7 (9) ◽  
pp. 1503-1509 ◽  
Author(s):  
Qiang Li ◽  
Jun Cao ◽  
Qi Wang ◽  
Jie Zhang ◽  
Shiqin Zhu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Tumor Microenvironment ◽  
Drug Release ◽  
Real Time ◽  
Tumor Targeting ◽  
Activation Process ◽  
Novel Approach ◽  
Real Time Tracking ◽  
Targeting Ability

A nanomized NIR fluorescent prodrug was developed with improved bioavailability and tumor-targeting ability. Nanomized tumor-microenvironment-active NIR DCM-S-GEM/PEG prodrug provides a novel approach to realize long real-time tracking of drug delivery and activation process without systemic toxicity in vivo.

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