Raman cell imaging with boron cluster molecules conjugated with biomolecules

Theoretically, within the diatomic model, there is studied the relative stability of most abundant boron clusters B11, B12, and B13 with planar structures in neutral, positively and negatively charge-states. According to the specific (pet atom) binding energy criterion, B12+ (6.49 eV) is found to be the most stable boron cluster, while B11– + B13+ (5.83 eV) neutral pair is expected to present the preferable ablation channel for boron-rich solids. Obtained results would be applicable in production of boron-clusters-based nanostructured coating materials with super-properties such as lightness, hardness, conductivity, chemically inertness, neutron-absorption, etc. making them especially effective for protection against cracking, wear, corrosion, neutron- and electromagnetic-radiations, etc.

Download Full-text

Relative stability of planar clusters B11, B12, and B13 in neutral- and charged-states

Characterization and Application of Nanomaterials ◽

10.24294/can.v0i0.761 ◽

2018 ◽

Cited By ~ 1

Author(s):

Levan Chkhartishvili

Keyword(s):

Binding Energy ◽

Relative Stability ◽

Energy Criterion ◽

Nanostructured Coating ◽

Neutron Absorption ◽

Coating Materials ◽

Boron Cluster ◽

Boron Clusters ◽

Planar Structures ◽

Electromagnetic Radiations

Theoretically, within the diatomic model, there is studied the relative stability of most abundant boron clusters B11, B12, and B13 with planar structures in neutral, positively and negatively charge-states. According to the specific (pet atom) binding energy criterion, B12+ (6.49 eV) is found to be the most stable boron cluster, while B11– + B13+ (5.83 eV) neutral pair is expected to present the preferable ablation channel for boron-rich solids. Obtained results would be applicable in production of boron-clusters-based nanostructured coating materials with super-properties such as lightness, hardness, conductivity, chemically inertness, neutron-absorption, etc. making them especially effective for protection against cracking, wear, corrosion, neutron- and electromagnetic-radiations, etc.

Download Full-text

Investigation of the Possibility of Application of Boron Clusters in Composite Materials with Metal Matrix

Advanced Materials Research ◽

10.4028/www.scientific.net/amr.59.96 ◽

2008 ◽

Vol 59 ◽

pp. 96-100 ◽

Cited By ~ 3

Author(s):

Vladimir A. Popov ◽

K.Y. Zhizhin ◽

N.T. Kuznetsov ◽

K.P. Staudhammer ◽

V.M. Retivov

Keyword(s):

Composite Materials ◽

Mechanical Alloying ◽

Metal Matrix ◽

Chemical Properties ◽

Matrix Composites ◽

Cluster Anions ◽

Boron Cluster ◽

Boron Clusters ◽

Physical Chemical ◽

Light Components

The main results of the investigation of boron-containing compounds that are planed to use as light components for creation of metal-matrix composites (MMC) are presented in the paper. A number of new general procedures have been developed, physical-chemical properties of boron cluster anions BnHn 2- (n = 10, 12) were investigated. Method of MMC fabrication is based on mechanical alloying and following compaction.

Download Full-text

Boron clusters as a platform for new materials: composites of nucleic acids and oligofunctionalized carboranes (C2B10H12) and their assembly into functional nanoparticles

Nanoscale ◽

10.1039/c9nr06550d ◽

2020 ◽

Vol 12 (1) ◽

pp. 103-114 ◽

Cited By ~ 4

Author(s):

Damian Kaniowski ◽

Katarzyna Ebenryter-Olbinska ◽

Katarzyna Kulik ◽

Slawomir Janczak ◽

Anna Maciaszek ◽

...

Keyword(s):

Gene Expression ◽

Nucleic Acids ◽

Gene Expression Regulation ◽

Therapeutic Potential ◽

Building Blocks ◽

New Materials ◽

Boron Cluster ◽

Boron Clusters ◽

Functional Nanoparticles ◽

Dual Action

The building blocks based on boron cluster spanning two short DNA adapters assemble into functional nanoparticles due to the formation of DNA helices. They offer dual-action therapeutic potential, e.g., in the BNCT and gene expression regulation.

Download Full-text

Nucleoside bearing boron clusters and their phosphoramidites – building blocks for modified oligonucleotide synthesis

New Journal of Chemistry ◽

10.1039/c4nj01096e ◽

2015 ◽

Vol 39 (2) ◽

pp. 1202-1221 ◽

Cited By ~ 17

Author(s):

Michał Matuszewski ◽

Agnieszka Kiliszek ◽

Wojciech Rypniewski ◽

Zbigniew J. Lesnikowski ◽

Agnieszka B. Olejniczak

Keyword(s):

Building Blocks ◽

Electrochemical Characteristics ◽

Oligonucleotide Synthesis ◽

X Ray ◽

Boron Cluster ◽

Boron Clusters ◽

Modified Oligonucleotide

Synthesis of four canonical nucleoside-closo-/nido-carborane conjugates, their phosphoramidites, their electrochemical characteristics and the first example of the X-ray structure of a nucleoside-boron cluster conjugate.

Download Full-text

Boron Units as Pharmacophores - New Applications and Opportunities of Boron Cluster Chemistry

Collection of Czechoslovak Chemical Communications ◽

10.1135/cccc20071646 ◽

2007 ◽

Vol 72 (12) ◽

pp. 1646-1658 ◽

Cited By ~ 77

Author(s):

Zbigniew J. Lesnikowski

Keyword(s):

Thermal Stability ◽

Drug Design ◽

Biologically Active ◽

Cluster Compounds ◽

Hydrophobic Core ◽

Cluster Chemistry ◽

Boron Cluster ◽

Boron Clusters ◽

Biological Environment ◽

New Applications

Carboranes (dicarba-closo-dodecaboranes) are a class of carbon-containing polyhedral boron-cluster compounds showing remarkable hydrophobic character, chemical and thermal stability, and resistance to catabolism in biological environment. These features allow application of boron clusters as new hydrophobic core structure in biologically active molecules that interact hydrophobically with proteins, thus facilitating new drug design. A review with 45 references.

Download Full-text

Aromatic cage-like B46: existence of the largest decagonal holes in stable atomic clusters

RSC Advances ◽

10.1039/c7ra02870a ◽

2017 ◽

Vol 7 (36) ◽

pp. 22243-22247 ◽

Cited By ~ 14

Author(s):

Truong Ba Tai ◽

Minh Tho Nguyen

Keyword(s):

Atomic Clusters ◽

Boron Cluster ◽

Boron Clusters ◽

New Family ◽

Aromatic Cage

The boron cluster B46has a cage-like structure containing two hexagonal, two heptagonal and two decagonal holes. This finding presents a new family of cage-like boron clusters containing large BNholes withN= 6–10.

Download Full-text

Imitation and modification of bioactive lead structures via integration of boron clusters

Pure and Applied Chemistry ◽

10.1351/pac-con-11-11-02 ◽

2012 ◽

Vol 84 (11) ◽

pp. 2289-2298 ◽

Cited By ~ 11

Author(s):

Sven Stadlbauer ◽

René Frank ◽

Matthias Scholz ◽

Solveig Boehnke ◽

Verena M. Ahrens ◽

...

Keyword(s):

Solid Phase ◽

Solid Phase Peptide Synthesis ◽

Water Soluble ◽

Carboxyl Group ◽

Boron Cluster ◽

Boron Clusters ◽

Cyclooxygenase 1 ◽

Modified Peptides ◽

Low Cytotoxicity

In medicinal chemistry, carbaboranes can be employed either as boron carriers for boron neutron capture therapy (BNCT) or as scaffolds for radiodiagnostic or therapeutic agents. We have developed a suitable synthesis employing the phosphoramidite method to connect meta-carbaboranyl bis-phosphonites with the 6'-OH group of isopropylidene-protected galactose, followed by oxidation or sulfurization to give the corresponding bis-phosphonates. Deprotection yielded water-soluble compounds. The corresponding disodium salts exhibit especially low cytotoxicity. Preliminary results on the in vivo toxicity and biodistribution of two compounds in mice indicated a lack of selectivity for the cotton rat lung (CRL) tumor chosen for the experiment. For the incorporation of carbaboranes into breast tumor-selective modified neuropeptide Y, [F7, P34]-NPY, a synthesis of a carbaborane-modified lysine derivative was developed. Linkage of the lysine to the boron cluster was achieved by using a propionic acid spacer. Incorporation of the amino acid derivatives into NPY and [F7, P34]-NPY by solid-phase peptide synthesis was successful. Preliminary studies showed that the receptor binding affinity and signal transduction of the boron-modified peptides were very well retained. Asborin, the carbaborane analogue of aspirin, is a rather weak inhibitor of cyclooxygenase-1 (COX-1) and COX-2, but a highly potent aldo/keto reductase 1A1 (AKR1A1) inhibitor. Modification either at the carboxyl group or at the chlorophenyl ring in indomethacin with ortho- and meta-carbaboranyl derivatives gave active derivatives only for the ortho-carbaborane directly attached to the carboxyl group, while the corresponding adamantyl and meta-carbaboranyl derivatives were inactive.

Download Full-text