scholarly journals A natural solution to photoprotection and isolation of the potent polyene antibiotic, marinomycin A

2019 ◽  
Vol 10 (32) ◽  
pp. 7549-7553 ◽  
Author(s):  
Christopher S. Bailey ◽  
Joseph S. Zarins-Tutt ◽  
Matthias Agbo ◽  
Hong Gao ◽  
Alberto Diego-Taboada ◽  
...  

Perfect partners for photoprotection: orally ingestible sporopollenin confers striking photoprotection to the powerful, polyene antibiotic, marinomycin A, as well as enabling its selective extraction.

Author(s):  
O. Yu. Kichigina

At production of stainless steel expensive alloying elements, containing nickel, are used. To decrease the steel cost, substitution of nickel during steel alloying process by its oxides is an actual task. Results of analysis of thermodynamic and experimental studies of nickel reducing from its oxide presented, as well as methods of nickel oxide obtaining at manganese bearing complex raw materials enrichment and practice of its application during steel alloying. Technology of comprehensive processing of complex manganese-containing raw materials considered, including leaching and selective extraction out of the solution valuable components: manganese, nickel, iron, cobalt and copper. Based on theoretical and experiment studies, a possibility of substitution of metal nickel by concentrates, obtained as a result of hydrometallurgical enrichment, was confirmed. Optimal technological parameters, ensuring high degree of nickel recovery out of the initial raw materials were determined. It was established, that for direct steel alloying it is reasonable to add into the charge pellets, consisting of nickel concentrate and coke fines, that enables to reach the through nickel recovery at a level of 90%. The proposed method of alloying steel by nickel gives a possibility to decrease considerably steel cost at the expense of application of nickel concentrate, obtained out of tails of hydrometallurgical enrichment of manganese-bearing raw materials, which is much cheaper comparing with the metal nickel.


Author(s):  
Wesley J. Wildman

Ground-of-being models regard ultimate reality as holy or sacred (unlike subordinate-deity models) and reject the idea that ultimate reality is an aware, agential being (unlike agential-being models). Ground-of-being models are radically anti-anthropomorphic, resisting the Intentionality Attribution, Narrative Comprehensibility, and Rational Practicality dimensions of anthropomorphism simultaneously. They are strongly amenable to the scientific study of religion and to apophatic metaphysical frameworks, within which ultimate reality surpasses the complete cognitive grasp of any possible creature. They offer a compelling and natural solution to the problem of religious diversity. They are and have always been relatively less popular than agential-being and subordinate-deity ultimacy models but it is not impossible to imagine a civilizational transformation after which ground-of-being models would become the dominant religious outlook. Variations, strengths, and weaknesses of the ground-of-being class of ultimacy models are discussed.


ACS Omega ◽  
2021 ◽  
Author(s):  
Paula Andrea Hernandez ◽  
Miaomiao Zhou ◽  
Igor Vassilev ◽  
Stefano Freguia ◽  
Yang Zhang ◽  
...  

Symmetry ◽  
2021 ◽  
Vol 13 (2) ◽  
pp. 358
Author(s):  
Roberto Casadio ◽  
Andrea Giusti

Bootstrapped Newtonian gravity was developed with the purpose of estimating the impact of quantum physics in the nonlinear regime of the gravitational interaction, akin to corpuscular models of black holes and inflation. In this work, we set the ground for extending the bootstrapped Newtonian picture to cosmological spaces. We further discuss how such models of quantum cosmology can lead to a natural solution to the cosmological constant problem.


2021 ◽  
Vol 11 (4) ◽  
pp. 1577
Author(s):  
Marco Mora-Granados ◽  
David González-Gómez ◽  
Jin Su Jeong ◽  
Alejandrina Gallego-Picó

Studies for monitoring the bioavailability of dietary flavonoid compounds generate great interest. Among them, low-molecular-weight phenolic acids, secondary metabolites present in colonic catabolism and urinary excretion, have been proposed as biomarkers of polyphenol intake. Using 4-hydroxyphenylacetic acid as a template, a molecularly imprinted polymer (MIP) was synthesized for selective extraction of these hydroxylated metabolites from human urine samples and posterior analysis in an HPLC-DAD-MS system. Polymers were characterized by Scanning electron microscopy (SEM), Attenuated total reflection-Fourier transform infrared spectroscopy (ATR-FTIR), Brunauer-Emmett-Teller (BET) method, and binding experiments. MIP presents specific recognition ability for template and analogues molecules. This capacity of recognition and the pH dependence of the binding strength was also studied. The method was validated over a concentration range of 0.25–40 mg/L, r2 > 0.995. In the optimized conditions, the recovery value was 94% with RSD 1.2%. The Limit of Detection (LOD) and Limit of Quantification (LOQ) were 1.22 and 3.69 mg/L, respectively. In our knowledge, it is the first time that this methodology is applied to analyze urinary catabolites of the polyphenol compound and to provide a specific method and simple analysis alternative. The selective extraction of these metabolites improves the application and results obtained by other less sensitive analysis methods than the validation method. It also facilitates the development of new screening methods.


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