scholarly journals Highly efficient singlet oxygen generation, two-photon photodynamic therapy and melanoma ablation by rationally designed mitochondria-specific near-infrared AIEgens

2020 ◽  
Vol 11 (9) ◽  
pp. 2494-2503 ◽  
Author(s):  
Zheng Zheng ◽  
Haixiang Liu ◽  
Shaodong Zhai ◽  
Haoke Zhang ◽  
Guogang Shan ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Singlet Oxygen ◽  
Near Infrared ◽  
Molecular Engineering ◽  
Photon Absorption ◽  
Oxygen Generation ◽  
Two Photon Absorption ◽  
Two Photon ◽  
Singlet Oxygen Generation ◽  
Highly Efficient

Mitochondria-targeted photosensitizers with highly efficient singlet oxygen generation, bright near-infrared AIE and good two-photon absorption are obtained through ingenious molecular engineering for cancer cell-selective photodynamic therapy.

Diketopyrrolopyrrole-Porphyrin Conjugates with High Two-Photon Absorption and Singlet Oxygen Generation for Two-Photon Photodynamic Therapy

2014 ◽  
Vol 127 (1) ◽  
pp. 171-175 ◽  
Author(s):  
Julie Schmitt ◽  
Valérie Heitz ◽  
Angélique Sour ◽  
Frédéric Bolze ◽  
Hussein Ftouni ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Singlet Oxygen ◽  
Photon Absorption ◽  
Oxygen Generation ◽  
Two Photon Absorption ◽  
Two Photon ◽  
Singlet Oxygen Generation

Diketopyrrolopyrrole-Porphyrin Conjugates with High Two-Photon Absorption and Singlet Oxygen Generation for Two-Photon Photodynamic Therapy

2014 ◽  
Vol 54 (1) ◽  
pp. 169-173 ◽  
Author(s):  
Julie Schmitt ◽  
Valérie Heitz ◽  
Angélique Sour ◽  
Frédéric Bolze ◽  
Hussein Ftouni ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Singlet Oxygen ◽  
Photon Absorption ◽  
Oxygen Generation ◽  
Two Photon Absorption ◽  
Two Photon ◽  
Singlet Oxygen Generation

Singlet Oxygen Generation and Photocytotoxicity against Tumor Cell by Two-Photon Absorption

2007 ◽  
Vol 471 (1) ◽  
pp. 61-67 ◽  
Author(s):  
Kazuya Ogawa ◽  
Joanne T. Dy ◽  
Yoshiaki Kobuke ◽  
Shun-ichiro Ogura ◽  
Ichiro Okura
Keyword(s):  
Tumor Cell ◽  
Singlet Oxygen ◽  
Photon Absorption ◽  
Oxygen Generation ◽  
Two Photon Absorption ◽  
Two Photon ◽  
Singlet Oxygen Generation

Recent progress in efficient organic two-photon dyes for fluorescence imaging and photodynamic therapy

2020 ◽  
Vol 8 (19) ◽  
pp. 6342-6349 ◽  
Author(s):  
Liang Xu ◽  
Junzheng Zhang ◽  
Lingfeng Yin ◽  
Xueting Long ◽  
Wenying Zhang ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Fluorescence Imaging ◽  
Fluorescence Quantum Yield ◽  
Organic Dyes ◽  
Photon Absorption ◽  
Generation Efficiency ◽  
Oxygen Generation ◽  
Two Photon Absorption ◽  
Two Photon ◽  
Singlet Oxygen Generation

The enhancement of two-photon absorption cross-section, fluorescence quantum yield and singlet oxygen generation efficiency for organic dyes and their applications in two-photon excited fluorescence imaging and photodynamic therapy are summarized.

Cooperative porphyrin-quadrupolar based triad for combined two-photon induced fluorescence and singlet oxygen generation

2017 ◽  
Vol 21 (02) ◽  
pp. 77-87 ◽  
Author(s):  
Jean-Baptiste Verlhac ◽  
Guillaume Clermont ◽  
Mireille Blanchard-Desce
Keyword(s):  
Singlet Oxygen ◽  
Photon Absorption ◽  
Absorption Properties ◽  
Oxygen Generation ◽  
Two Photon Absorption ◽  
Design And Synthesis ◽  
Two Photon ◽  
Singlet Oxygen Generation ◽  
Potential Applications ◽  
Order Of Magnitude

The design and synthesis of a cooperative multichromophoric triad system which combines the large two-photon absorption properties of fluorene-cored bis-donor quadropolar dyes and the remarkable sensitizing properties of the porphyrin subunit (i.e. high intersystem crossing and ability to produce singlet oxygen by energy transfer to oxygen from its triplet excited state) is described. After irradiation the energy can be transferred from the quadrupolar chromophores to the porphyrin with an estimated 80% efficiency via a FRET process. Moreover both the two-photon absorption properties of the quadrupolar subunits and the sensitizing and fluorescence properties of the porphyrin are retained indicating that deleterious competing processes (such as photo-induced electron transfer) are prevented in such molecular architectures thanks to the implemented design. As a result, the two-photon absorption induced singlet oxygen generation efficiency of the triad in the NIR region is found to be enhanced by an order of magnitude as compared to the porphyin subunit. Potential applications of these porphyrin-based multichromophoric systems for photodynamic therapy based upon two-photon excitation in the NIR region might be possible since it overcomes the low two-photon absorption response of porphyrin while fully retaining their remarkable photosensitizing properties.

Enhancement of Two-Photon Absorption Cross-Section and Singlet-Oxygen Generation in Porphyrins upon β-Functionalization with Donor−Acceptor Substituents

2006 ◽  
Vol 8 (13) ◽  
pp. 2719-2722 ◽  
Author(s):  
Marika Morone ◽  
Luca Beverina ◽  
Alessandro Abbotto ◽  
Fabio Silvestri ◽  
Elisabetta Collini ◽  
...  
Keyword(s):  
Singlet Oxygen ◽  
Cross Section ◽  
Absorption Cross Section ◽  
Photon Absorption ◽  
Absorption Cross ◽  
Oxygen Generation ◽  
Two Photon Absorption ◽  
Two Photon ◽  
Singlet Oxygen Generation ◽  
Donor Acceptor

scholarly journals Heterometallic Ru–Pt metallacycle for two-photon photodynamic therapy

2018 ◽  
Vol 115 (22) ◽  
pp. 5664-5669 ◽  
Author(s):  
Zhixuan Zhou ◽  
Jiangping Liu ◽  
Thomas W. Rees ◽  
Heng Wang ◽  
Xiaopeng Li ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Singlet Oxygen ◽  
Near Infrared ◽  
Photon Absorption ◽  
In Vivo Studies ◽  
Target Tissue ◽  
Noninvasive Treatment ◽  
Two Photon Absorption ◽  
Two Photon

As an effective and noninvasive treatment of various diseases, photodynamic therapy (PTD) relies on the combination of light, a photosensitizer, and oxygen to generate cytotoxic reactive oxygen species that can damage malignant tissue. Much attention has been paid to covalent modifications of the photosensitizers to improve their photophysical properties and to optimize the pathway of the photosensitizers interacting with cells within the target tissue. Herein we report the design and synthesis of a supramolecular heterometallic Ru–Pt metallacycle via coordination-driven self-assembly. While inheriting the excellent photostability and two-photon absorption characteristics of the Ru(II) polypyridyl precursor, the metallacycle also exhibits red-shifted luminescence to the near-infrared region, a larger two-photon absorption cross-section, and higher singlet oxygen generation efficiency, making it an excellent candidate as a photosensitizer for PTD. Cellular studies reveal that the metallacycle selectively accumulates in mitochondria and nuclei upon internalization. As a result, singlet oxygen generated by photoexcitation of the metallacycle can efficiently trigger cell death via the simultaneous damage to mitochondrial function and intranuclear DNA. In vivo studies on tumor-bearing mice show that the metallacycle can efficiently inhibit tumor growth under a low light dose with minimal side effects. The supramolecular approach presented in this work provides a paradigm for the development of PDT agents with high efficacy.

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