Electrospun nanofibers of polyelectrolyte–surfactant complexes for antibacterial wound dressing application

Soft Matter ◽  
2019 ◽  
Vol 15 (48) ◽  
pp. 10020-10028 ◽  
Author(s):  
Qiaohua Qiu ◽  
Jiajun Wu ◽  
Zhenzhen Quan ◽  
Hongnan Zhang ◽  
Xiaohong Qin ◽  
...  
Keyword(s):  
Solid State ◽  
Wound Dressing ◽  
Electrospun Nanofibers

The polyelectrolyte–surfactant complexes (PESCs) novel antibacterial fibers were fabricated via electrospinning of PESCs in solid state without any additives.

scholarly journals Experimental Investigation of the Properties of Electrospun Nanofibers for Potential Medical Application

2015 ◽  
Vol 2015 ◽  
pp. 1-8 ◽  
Author(s):  
Anhui Wang ◽  
Chao Xu ◽  
Chuanwei Zhang ◽  
Yunna Gan ◽  
Bin Wang
Keyword(s):  
Wound Dressing ◽  
Transmission Rate ◽  
Electrospun Nanofibers ◽  
Medical Application ◽  
Superior Performance ◽  
Fluid Uptake ◽  
Ag Particles ◽  
Dressing Materials ◽  
Potential Use

Polymer based nanofibers using ethylene-co-vinyl alcohol (EVOH) were fabricated by electrospinning technology. The nanofibers were studied for potential use as dressing materials for skin wounds treatment. Properties closely related to the clinical requirements for wound dressing were investigated, including the fluid uptake ability (FUA), the water vapour transmission rate (WVTR), the bacteria control ability of nanofibers encapsulated with different antibacterial drugs, and Ag of various concentrations. Nanofibre degradation under different environmental conditions was also studied for the prospect of long term usage. The finding confirms the potential of EVOH nanofibers for wound dressing application, including the superior performance compared to cotton gauze and the strong germ killing capacity when Ag particles are present in the nanofibers.

scholarly journals Characterization, Antibacterial and Anti-Inflammatory Activities of Electrospun poly (vinyl alcohol) (PVA) Containing Aquilaria malaccencis Leaf Extract (ALEX) Nanofibers

2020 ◽  
Vol 9 (3) ◽  
pp. 541-548
Keyword(s):  
Vinyl Alcohol ◽  
Wound Dressing ◽  
Leaf Extract ◽  
Vibrio Vulnificus ◽  
Electrospun Nanofibers ◽  
Poly Vinyl Alcohol ◽  
Scanning Calorimetry ◽  
Swelling Degree ◽  
Anti Inflammatory ◽  
Nanofiber Mats

Plant-based electrospun nanofibers are widely fabricated as wound dressing in recent years primarily due to the presence of bioactive compounds which can facilitate the wound healing effects. In this study, poly(vinyl alcohol) (PVA) fibre mats containing Aquilaria malaccensis leaf extract (ALEX) [5, 10 and 15 %(w/w)] were fabricated by electrospinning method as potential wound dressing material. The nanofibers were uniform, beadless and randomly oriented with average diameters ranged between 195.27 – 281.20 nm. The presence of ALEX in the PVA nanofibers were evaluated by Attenuated total reflectance-Fourier transform infrared spectroscopy (ATR-FTIR) and differential scanning calorimetry (DSC). The mechanical properties, swelling degree and weight loss of nanofiber mats were also determined. ALEX was rapidly released from the ALEX-loaded PVA nanofibers in the first 12 hours and increased gradually afterwards. The released rate of ALEX was dependent on the ALEX content in the PVA nanofibers. This result is also contributed by the swelling degree and porosity of the nanofibers where the results were found to be between 241.66 – 305.86% and 64.53 – 30.81%, respectively. Meanwhile, the tensile stress and maximum elongation at break for all electrospun nanofiber mats were in the range of 8.56 – 2.68 MPa and 205.94 – 166.31%, respectively. The nanofiber mats inhibited growth of Escherichia coli, Vibrio vulnificus, Bacillus subtilis and Staphylococcus aureus with zone of inhibition of 7.5 - 15.0 mm for gram positive bacteria and 6.1 - 11.7 mm for gram negative bacteria. ALEX-loaded PVA nanofibers also showed potent anti-inflammatory activity against lipoxygenase with percentage of inhibition between 80.887 – 86.977%. Taken together, the results of this study suggest that ALEX-loaded PVA nanofibers have the desired properties of bioactive wound dressing.

Diltiazem-loaded electrospun nanofibers as a new wound dressing: fabrication, characterization, and experimental wound healing

2020 ◽  
pp. 1-14
Author(s):  
Ramin Seyedian ◽  
Elham Shabankareh Fard ◽  
Seyede Sahar Hashemi ◽  
Hossein Hasanzadeh ◽  
Majid Assadi ◽  
...  
Keyword(s):  
Wound Healing ◽  
Wound Dressing ◽  
Electrospun Nanofibers

Evaluation of poly ε-caprolactone electrospun nanofibers loaded with Hypericum perforatum extract as a wound dressing

2016 ◽  
Vol 43 (1) ◽  
pp. 297-320 ◽  
Author(s):  
Faegheh Pourhojat ◽  
Mahmoodreza Sohrabi ◽  
Shahab Shariati ◽  
Hamid Mahdavi ◽  
Leila Asadpour
Keyword(s):  
Wound Dressing ◽  
Hypericum Perforatum ◽  
Electrospun Nanofibers

Tetracycline hydrochloride-loaded electrospun nanofibers mats based on PVA and chitosan for wound dressing

2017 ◽  
Vol 77 ◽  
pp. 271-281 ◽  
Author(s):  
Alex Carvalho Alavarse ◽  
Fernanda Waitman de Oliveira Silva ◽  
Jandir Telleria Colque ◽  
Viviam Moura da Silva ◽  
Tatiane Prieto ◽  
...  
Keyword(s):  
Wound Dressing ◽  
Electrospun Nanofibers ◽  
Tetracycline Hydrochloride

scholarly journals Epidermal and fibroblast growth factors incorporated polyvinyl alcohol electrospun nanofibers as biological dressing scaffold

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Amnah Asiri ◽  
Syafiqah Saidin ◽  
Mohd Helmi Sani ◽  
Rania Hussien Al-Ashwal
Keyword(s):  
Cell Proliferation ◽  
Growth Factors ◽  
Growth Factor ◽  
Polyvinyl Alcohol ◽  
Wound Dressing ◽  
Electrospun Nanofibers ◽  
In Vivo Studies ◽  
Fibroblast Growth ◽  
Biological Dressing

AbstractIn this study, single, mix, multilayer Polyvinyl alcohol (PVA) electrospun nanofibers with epidermal growth factor (EGF) and fibroblast growth factor (FGF) were fabricated and characterized as a biological wound dressing scaffolds. The biological activities of the synthesized scaffolds have been verified by in vitro and in vivo studies. The chemical composition finding showed that the identified functional units within the produced nanofibers (O–H and N–H bonds) are attributed to both growth factors (GFs) in the PVA nanofiber membranes. Electrospun nanofibers' morphological features showed long protrusion and smooth morphology without beads and sprayed with an average range of 198–286 nm fiber diameter. The fiber diameters decrement and the improvement in wettability and surface roughness were recorded after GFs incorporated within the PVA Nanofibers, which indicated potential good adoption as biological dressing scaffolds due to the identified mechanical properties (Young’s modulus) in between 18 and 20 MPa. The MTT assay indicated that the growth factor release from the PVA nanofibers has stimulated cell proliferation and promoted cell viability. In the cell attachment study, the GFs incorporated PVA nanofibers stimulated cell proliferation and adhered better than the PVA control sample and presented no cytotoxic effect. The in vivo studies showed that compared to the control and single PVA-GFs nanofiber, the mix and multilayer scaffolds gave a much more wound reduction at day 7 with better wound repair at day 14–21, which indicated to enhancing tissue regeneration, thus, could be a projected as a suitable burn wound dressing scaffold.

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