scholarly journals Experimental Investigation of the Properties of Electrospun Nanofibers for Potential Medical Application

2015 ◽  
Vol 2015 ◽  
pp. 1-8 ◽  
Author(s):  
Anhui Wang ◽  
Chao Xu ◽  
Chuanwei Zhang ◽  
Yunna Gan ◽  
Bin Wang
Keyword(s):  
Wound Dressing ◽  
Transmission Rate ◽  
Electrospun Nanofibers ◽  
Medical Application ◽  
Superior Performance ◽  
Fluid Uptake ◽  
Ag Particles ◽  
Dressing Materials ◽  
Potential Use

Polymer based nanofibers using ethylene-co-vinyl alcohol (EVOH) were fabricated by electrospinning technology. The nanofibers were studied for potential use as dressing materials for skin wounds treatment. Properties closely related to the clinical requirements for wound dressing were investigated, including the fluid uptake ability (FUA), the water vapour transmission rate (WVTR), the bacteria control ability of nanofibers encapsulated with different antibacterial drugs, and Ag of various concentrations. Nanofibre degradation under different environmental conditions was also studied for the prospect of long term usage. The finding confirms the potential of EVOH nanofibers for wound dressing application, including the superior performance compared to cotton gauze and the strong germ killing capacity when Ag particles are present in the nanofibers.

scholarly journals Radiation sterilization of Honey and Honey-Alginate Wound Dressing from Stingless Bee (Tetragonula biroi) Collected from Sta. Maria, Laguna, Philippines

2021 ◽  
Vol 11 (2) ◽  
pp. 217-223
Author(s):  
Davison Baldos ◽  
◽  
Joseph Puno ◽  
Levelyn Tolentino ◽  
Djowel Montefalcon ◽  
...  
Keyword(s):  
Electron Beam ◽  
Physicochemical Properties ◽  
Wound Dressing ◽  
Transmission Rate ◽  
Wound Care ◽  
Stingless Bee ◽  
Soluble Solids ◽  
Radiation Sterilization ◽  
Fluid Handling ◽  
Potential Use

This study was conducted to determine the effect of radiation sterilization on alginate wound dressing containing honey from the Philippine stingless bee, Tetragonula biroi. Our results show that a radiation dose of 30 kGy did not affect the antibacterial property of honey against Staphylococcus aureus. Electron-beam irradiation did not produce significant alterations in the physicochemical properties (pH, total soluble solids, and flavonoids); however, the total phenolics was significantly increased in honey with higher irradiation doses. Demonstrating that irradiation can be applied to honey with negligible physicochemical effects, honey was incorporated in alginate and exposed to a sterilization dose of 25 kGy using an electron beam facility. Irradiation did not affect the physicochemical properties (pH, moisture content, gel fraction, moisture vapor transmission rate (MVTR), and fluid handling capacity) of the honey alginate wound dressing (HAWD). The perspectives for the potential use of irradiated HAWD as a natural product-based substitute for commercial wound care products may be considered.

The potential use of gentamicin sulfate-loaded silk fibroin/gelatin blend scaffolds for wound dressing materials

2017 ◽  
Vol 75 (6) ◽  
pp. 2543-2558 ◽  
Author(s):  
Kitipong Kiti ◽  
Pathomporn Kudithalert ◽  
Teerawit Waratrujiwong ◽  
Orawan Suwantong
Keyword(s):  
Silk Fibroin ◽  
Wound Dressing ◽  
Gentamicin Sulfate ◽  
Dressing Materials ◽  
Potential Use ◽  
Wound Dressing Materials

Swelling Behaviour and Water Vapour Transmission Rates of Gellan Gum/Collagen Film Containing Gatifloxacin as Dressing Materials

2021 ◽  
Vol 1041 ◽  
pp. 75-79
Author(s):  
Aznatul Jannah Abu Bakar ◽  
Khairul Anuar Mat Amin
Keyword(s):  
Water Vapour ◽  
Wound Dressing ◽  
Transmission Rate ◽  
Gellan Gum ◽  
Casting Method ◽  
Swelling Behaviour ◽  
Collagen Film ◽  
Collagen Hydrogel ◽  
Water Vapour Transmission Rate ◽  
Dressing Materials

In an effort to produce ideal wound dressing, gellan gum/collagen hydrogel films containing different concentrations of gatifloxacin were prepared via evaporative casting method. The films were examined in terms of physical appearances, water uptake and water vapour transmission rate (WVTR). All the films showed good physical appearances. Swelling percentages of the films were decreased, whereas WVTR values were increased as the addition of gatifloxacin was increased. Swelling percentage of gellan gum/collagen film with the lowest percentage of gatifloxacin (GG/C-GAT01) has the highest swelling ratio (2057%). Meanwhile, the WVTR value of GG/C-GAT1 has the highest WVTR value among all films which is 1245 g m-2 day-1. The formulation of GG/C films with the addition of gatifloxacin with good water absorbance and acceptable WVTRs value offered promising materials to be applied as wound dressing materials.

scholarly journals Long-Term Antibacterial Film Nanocomposite Incorporated with Patchouli Essential Oil Prepared by Supercritical CO2 Cyclic Impregnation for Wound Dressing

Molecules ◽  
2021 ◽  
Vol 26 (16) ◽  
pp. 5005
Author(s):  
Jingfu Jia ◽  
Shulei Duan ◽  
Xue Zhou ◽  
Lifang Sun ◽  
Chengyuan Qin ◽  
...  
Keyword(s):  
Essential Oil ◽  
Supercritical Co2 ◽  
Wound Dressing ◽  
Mesoporous Silica Nanoparticles ◽  
Skin Wound ◽  
Mouse Fibroblast ◽  
Elongation At Break ◽  
Promising Strategy ◽  
Dressing Materials

Biocompatible skin wound dressing materials with long-term therapeutic windows and anti-infection properties have attracted great attention all over the world. The cooperation between essential oil and non-toxic or bio-based polymers was a promising strategy. However, the inherent volatility and chemical instability of most ingredients in essential oils make the sustained pharmacological activity of essential oil-based biomaterials a challenge. In this study, a kind of film nanocomposite loaded with patchouli essential oil (PEO-FNC) was fabricated. PEO-loaded mesoporous silica nanoparticles (PEO-MSNs) with drug load higher than 40 wt% were firstly prepared using supercritical CO2 cyclic impregnation (SCCI), and then combined with the film matrix consisting of polyvinyl alcohol and chitosan. The morphology of PEO-MSNs and PEO-FNC was observed by transmission and scanning electron microscope. The mechanical properties, including hygroscopicity, tensile strength and elongation at break (%), were tested. The release behavior of PEO from the film nanocomposite showed that PEO could keep releasing for more than five days. PEO-FNC exhibited good long-term (>48 h) antibacterial effect on Staphylococcus aureus and non-toxicity on mouse fibroblast (L929 cells), making it a promising wound dressing material.

Treatment and secondary prevention of venous thromboembolism in cancer patients

2012 ◽  
Vol 03 (03) ◽  
pp. 121-125
Author(s):  
I. Pabinger ◽  
C. Ay
Keyword(s):  
Clinical Trials ◽  
Venous Thromboembolism ◽  
Cancer Patients ◽  
Oral Anticoagulants ◽  
Factor Xa ◽  
New Oral Anticoagulants ◽  
Phase Iii ◽  
Patients With Cancer ◽  
Potential Use

SummaryCancer is a major and independent risk factor of venous thromboembolism (VTE). In clinical practice, a high number of VTE events occurs in patients with cancer, and treatment of cancerassociated VTE differs in several aspects from treatment of VTE in the general population. However, treatment in cancer patients remains a major challenge, as the risk of recurrence of VTE as well as the risk of major bleeding during anticoagulation is substantially higher in patients with cancer than in those without cancer. In several clinical trials, different anticoagulants and regimens have been investigated for treatment of acute VTE and secondary prophylaxis in cancer patients to prevent recurrence. Based on the results of these trials, anticoagulant therapy with low-molecular-weight heparins (LMWH) has become the treatment of choice in cancer patients with acute VTE in the initial period and for extended and long-term anticoagulation for 3-6 months. New oral anticoagulants directly inhibiting thrombin or factor Xa, have been developed in the past decade and studied in large phase III clinical trials. Results from currently completed trials are promising and indicate their potential use for treatment of VTE. However, the role of the new oral thrombin and factor Xa inhibitors for VTE treatment in cancer patients still has to be clarified in further studies specifically focusing on cancer-associated VTE. This brief review will summarize the current strategies of initial and long-term VTE treatment in patients with cancer and discuss the potential use of the new oral anticoagulants.

Investigation of Dialdehyde Corn Starch as Crosslinking Agent in Collagen-Based Wound Dressing Materials

2016 ◽  
Author(s):  
Cigdem Kilicarislan Ozkan ◽  
Hasan Ozgunay ◽  
Stefania Marin ◽  
Madalina Georgiana Albu Kaya
Keyword(s):  
Wound Dressing ◽  
Corn Starch ◽  
Crosslinking Agent ◽  
Dressing Materials ◽  
Wound Dressing Materials

G × E interaction studies in relation to heterosis and stability of grain yield in maize (Zea mays L.)

2020 ◽  
Vol 80 (03) ◽  
Author(s):  
K. Sumalini ◽  
T. Pradeep ◽  
D. Sravani
Keyword(s):  
Grain Yield ◽  
Zea Mays L ◽  
Yield Stability ◽  
Superior Performance ◽  
Dominant Effect ◽  
Stability Parameters ◽  
Hybrid Classes ◽  
Maize Inbreds ◽  
Comparative Stability ◽  
Potential Use

Interaction of homozygous inbreds and heterozygous single, three way and double crosses with environment had shown a differential response in achieving yield stability. Seven diverse maize inbreds, their 21 single crosses and 105 each of three way and double crosses obtained through diallel were evaluated for twelve characters across three diverse locations to estimate comparative stability of homozygous and heterozygous genotypes for grain yield. Contrasts in heterobeltiosis, combining ability and stability parameters in three environments and interaction effects were observed. Gain in heterobeltiosis (%) for grain yield was observed with decreased environmental quality in different hybrid classes suggesting that heterozygous hybrids are more stable due to individual buffering in single crosses and both individual and population buffering in case of three way and double crosses. Significant increase in SCA effects was observed in moderate environment at Hyderabad rather than at high yielding environment Palem. Significant G × E and Environment (linear) in all the crosses was observed for grain yield suggesting the effect of environment and its pre dominant effect on grain yield. Stability of hybrids was attributed to their superior performance over the parents in low yielding environment. Thus the potential use of selected heterozygous hybrids would allow under diverse environments is suggested to mitigate losses arising out of climate change.

Measuring Long Term Superior Performance: Or How to Compare Apples with Oranges

2008 ◽  
Author(s):  
George S. Yip ◽  
Timothy M. Devinney ◽  
Gerry Johnson
Keyword(s):  
Superior Performance

scholarly journals High-efficiency CO2 separation using hybrid LDH-polymer membranes

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Xiaozhi Xu ◽  
Jiajie Wang ◽  
Awu Zhou ◽  
Siyuan Dong ◽  
Kaiqiang Shi ◽  
...  
Keyword(s):  
Self Assembly ◽  
High Efficiency ◽  
Transmission Rate ◽  
Spray Coating ◽  
Separation Performance ◽  
Pdms Layer ◽  
Operational Testing ◽  
Enhanced Solubility ◽  
Double Hydroxide

AbstractMembrane-based gas separation exhibits many advantages over other conventional techniques; however, the construction of membranes with simultaneous high selectivity and permeability remains a major challenge. Herein, (LDH/FAS)n-PDMS hybrid membranes, containing two-dimensional sub-nanometre channels were fabricated via self-assembly of unilamellar layered double hydroxide (LDH) nanosheets and formamidine sulfinic acid (FAS), followed by spray-coating with a poly(dimethylsiloxane) (PDMS) layer. A CO2 transmission rate for (LDH/FAS)25-PDMS of 7748 GPU together with CO2 selectivity factors (SF) for SF(CO2/H2), SF(CO2/N2) and SF(CO2/CH4) mixtures as high as 43, 86 and 62 respectively are observed. The CO2 permselectivity outperforms most reported systems and is higher than the Robeson or Freeman upper bound limits. These (LDH/FAS)n-PDMS membranes are both thermally and mechanically robust maintaining their highly selective CO2 separation performance during long-term operational testing. We believe this highly-efficient CO2 separation performance is based on the synergy of enhanced solubility, diffusivity and chemical affinity for CO2 in the sub-nanometre channels.

Sign in / Sign up

Export Citation Format

Share Document