Bacterial acidity-triggered antimicrobial activity of self-assembling peptide nanofibers

2019 ◽  
Vol 7 (18) ◽  
pp. 2915-2919 ◽  
Author(s):  
Weike Chen ◽  
Shuxin Li ◽  
Paul Renick ◽  
Su Yang ◽  
Nikhil Pandy ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Ph Change ◽  
Self Assembling ◽  
Microenvironmental Ph ◽  
Peptide Nanofibers

A soluble, supramolecular peptide serves as an antimicrobial depot to release activated peptides in response to microenvironmental pH change around bacteria.

scholarly journals Investigating the In Vivo Antimicrobial Activity of a Self-Assembling Peptide Hydrogel Using a Galleria mellonella Infection Model

ACS Omega ◽  
2019 ◽  
Vol 4 (2) ◽  
pp. 2584-2589 ◽  
Author(s):  
Alice P. McCloskey ◽  
Merissa Lee ◽  
Julianne Megaw ◽  
Judith McEvoy ◽  
Sophie M. Coulter ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Galleria Mellonella ◽  
Infection Model ◽  
Self Assembling ◽  
Peptide Hydrogel

scholarly journals Self-assembling peptide nanofibers containing phenylalanine for the controlled release of 5-fluorouracil

2016 ◽  
Vol Volume 11 ◽  
pp. 5583-5594 ◽  
Author(s):  
N Ashwanikumar ◽  
Nisha Asok Kumar ◽  
Padma S Saneesh Babu ◽  
KC Sivakumar ◽  
Mithun Vadakkan ◽  
...  
Keyword(s):  
Controlled Release ◽  
Self Assembling ◽  
Peptide Nanofibers

scholarly journals Self-Assembling Peptide Nanofibers Coupled with Neuropeptide Substance P for Bone Tissue Engineering

2015 ◽  
Vol 21 (7-8) ◽  
pp. 1237-1246 ◽  
Author(s):  
Su Hee Kim ◽  
Woojune Hur ◽  
Ji Eun Kim ◽  
Hye Jeong Min ◽  
Sukwha Kim ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Substance P ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Self Assembling ◽  
Peptide Nanofibers

Harnessing self-assembling peptide nanofibers to prime robust tumor-specific CD8 T cell responses in mice

2022 ◽  
Vol 104 ◽  
pp. 108522
Author(s):  
Atefeh Mohseninia ◽  
Parva Dehghani ◽  
Afshar Bargahi ◽  
Mazda Rad-Malekshahi ◽  
Raha Rahimikian ◽  
...  
Keyword(s):  
T Cell ◽  
T Cell Responses ◽  
Cd8 T Cell ◽  
Cell Responses ◽  
Self Assembling ◽  
Peptide Nanofibers

Self-assembling peptide nanofibers promoting cell adhesion and differentiation

Biopolymers ◽  
2013 ◽  
Vol 100 (6) ◽  
pp. 731-737 ◽  
Author(s):  
Kazuto Fukunaga ◽  
Hiroshi Tsutsumi ◽  
Hisakazu Mihara
Keyword(s):  
Cell Adhesion ◽  
Self Assembling ◽  
Peptide Nanofibers

PRESENTATION OF BIOACTIVE EPITOPES WITH FREE N-TERMINI ON SELF-ASSEMBLING PEPTIDE NANOFIBERS

NANO ◽  
2011 ◽  
Vol 06 (01) ◽  
pp. 47-57 ◽  
Author(s):  
YANFEI LIU ◽  
XIAOJUN ZHAO
Keyword(s):  
Fluorescence Spectra ◽  
The Self ◽  
Self Assembling ◽  
Atomic Force ◽  
Peptide Nanofibers ◽  
N Terminus ◽  
Conformational Freedom ◽  
Β Sheets ◽  
Electrostatic Repulsions ◽  
Single Peptide

Branched self-assembling peptides bearing epitopes with free N-termini were designed. A lysine residue was used as branch point to present more than one epitopes in a single peptide. Atomic force microscope, circular dichroism and Fourier transform infrared spectroscopy data indicate that the N-terminus attached epitope sequences do not prevent the formation of the β-sheets and the self-assembling of these peptides into stable nanofibers in aqueous solutions. Rheology experiments show that these peptides could form self-supporting scaffolds once electrostatic repulsions were screened by electrolytes. Fluorescence spectra measurements upon binding of FITC-avidin to surfaces of nanofibers were performed to investigate the effect of charged aspartic acid residues in RGD epitopes at the lysine branching on packing and accessibility of the epitopes. Results show that the electrostatic interaction between hydrophilic side chains at branching and nanofiber surfaces may significantly affect the conformational freedom and accessibility of the epitopes at the periphery of the nanofibers. Cell entrapment experiments reveal that the attached RGD epitopes with free N-termini are biological active.

Self-assembling peptide nanofibers and skeletal myoblast transplantation in infarcted myocardium

2008 ◽  
Vol 87B (1) ◽  
pp. 222-228 ◽  
Author(s):  
Gilbert Dubois ◽  
Vincent F. M. Segers ◽  
Valérie Bellamy ◽  
Laurent Sabbah ◽  
Séverine Peyrard ◽  
...  
Keyword(s):  
Skeletal Myoblast ◽  
Infarcted Myocardium ◽  
Self Assembling ◽  
Peptide Nanofibers ◽  
Myoblast Transplantation

Self-Assembling Peptide Nanofibers for MMP Delivery and Cardiac Regeneration in Diabetes

2011 ◽  
Author(s):  
Jennifer R. Hurley ◽  
Abdul Q. Sheikh ◽  
Meredith Beckenhaupt ◽  
Cameron Ingram ◽  
Andrew Mutchler ◽  
...  
Keyword(s):  
Cardiac Fibrosis ◽  
Cardiac Fibroblasts ◽  
Cardiac Regeneration ◽  
The United States ◽  
Matrix Remodeling ◽  
Self Assembling ◽  
Peptide Nanofibers ◽  
Novel Target

Diabetes is a serious problem in the United States, afflicting 7.8% of the population with annual medical costs estimated at $116B in 2007 (1). Diabetic cardiomyopathy (DCM) is a cardiovascular complication of diabetes resulting in pathological alterations to the myocardium including circulatory defects, impaired heart muscle contraction, and progressive fibrosis. Cardiac fibrosis is associated with an imbalance between the deposition of the extracellular matrix (ECM) proteins by cardiac fibroblasts and the ECM proteolytic degradation via matrix metalloproteinases (MMPs). Recent studies have demonstrated that in the diabetic heart, expression and activity of MMP-2 are reduced, resulting in increased collagen accumulation and cardiac dysfunction (2). These observations suggest that a MMP-related mechanism may contribute to cardiac fibrosis, and that it may be attenuated through stimulation of native MMP-2 expression or delivery of exogenous MMP-2. Therefore, reduced MMP-2 activity in DCM may represent a novel target for therapeutic treatment (3). To achieve this, a special proteolytically-stable delivery scaffold would be needed, because native ECM is rapidly degraded by MMPs. The goal of this study is to determine if self-assembling peptide nanofibers can be used for long-term (several weeks) MMP delivery and enhancement of cardiac remodeling. This study tests the hypothesis that increased MMP-2 concentration (native or exogenous) in the nanofiber environment will promote matrix remodeling in diabetic cardiac fibroblasts in vitro.

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