scholarly journals Synthesis of acrylamide-based block-copolymer brushes under flow: monitoring real-time growth and surface restructuring upon drying

2020 ◽  
Vol 11 (18) ◽  
pp. 3209-3216 ◽  
Author(s):  
Joydeb Mandal ◽  
Andrea Arcifa ◽  
Nicholas D. Spencer
Keyword(s):  
Block Copolymer ◽  
Real Time ◽  
Quartz Crystal Microbalance ◽  
Continuous Flow ◽  
Quartz Crystal ◽  
Water Soluble ◽  
Surface Restructuring ◽  
Flow Monitoring ◽  
Copolymer Brushes

Block-copolymer brushes of water-soluble acrylamides have been synthesised by SI-ATRP under continuous flow and their growth monitored in situ by means of a quartz-crystal microbalance with dissipation (QCM-D).

scholarly journals In situ monitoring of SI-ATRP throughout multiple reinitiations under flow by means of a quartz crystal microbalance

RSC Advances ◽  
2018 ◽  
Vol 8 (36) ◽  
pp. 20048-20055 ◽  
Author(s):  
Joydeb Mandal ◽  
R. S. Varunprasaath ◽  
Wenqing Yan ◽  
Mohammad Divandari ◽  
Nicholas D. Spencer ◽  
...  
Keyword(s):  
Quartz Crystal Microbalance ◽  
Continuous Flow ◽  
Quartz Crystal ◽  
In Situ Monitoring ◽  
Atom Transfer ◽  
Hydroxyethyl Methacrylate ◽  
Radical Polymerisation

The polymerisation of 2-hydroxyethyl methacrylate (HEMA) by means of surface-initiated atom transfer radical polymerisation (SI-ATRP) has been studied in situ using a quartz crystal microbalance, with multiple reinitiations under continuous flow of the reaction mixture.

scholarly journals A Real-Time Method for Improving Stability of Monolithic Quartz Crystal Microbalance Operating under Harsh Environmental Conditions

Sensors ◽  
2021 ◽  
Vol 21 (12) ◽  
pp. 4166
Author(s):  
Román Fernández ◽  
María Calero ◽  
Yolanda Jiménez ◽  
Antonio Arnau
Keyword(s):  
Real Time ◽  
Quartz Crystal Microbalance ◽  
Quartz Crystal ◽  
Limit Of Detection ◽  
Quartz Substrate ◽  
Low Cost ◽  
Discrete Wavelet ◽  
Reagent Consumption ◽  
Measurement Cell ◽  
The Stability

Monolithic quartz crystal microbalance (MQCM) has recently emerged as a very promising technology suitable for biosensing applications. These devices consist of an array of miniaturized QCM sensors integrated within the same quartz substrate capable of detecting multiple target analytes simultaneously. Their relevant benefits include high throughput, low cost per sensor unit, low sample/reagent consumption and fast sensing response. Despite the great potential of MQCM, unwanted environmental factors (e.g., temperature, humidity, vibrations, or pressure) and perturbations intrinsic to the sensor setup (e.g., mechanical stress exerted by the measurement cell or electronic noise of the characterization system) can affect sensor stability, masking the signal of interest and degrading the limit of detection (LoD). Here, we present a method based on the discrete wavelet transform (DWT) to improve the stability of the resonance frequency and dissipation signals in real time. The method takes advantage of the similarity among the noise patterns of the resonators integrated in an MQCM device to mitigate disturbing factors that impact on sensor response. Performance of the method is validated by studying the adsorption of proteins (neutravidin and biotinylated albumin) under external controlled factors (temperature and pressure/flow rate) that simulate unwanted disturbances.

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