Chitosan modified metal–organic frameworks as a promising carrier for oral drug delivery

AbstractNanoparticles as drug delivery systems can alter the drugs' hydrophilicity to affect drug uptake and efflux in tissues. They prevent drugs from non-specifically binding with bio-macromolecules and enhance drug accumulation at the lesion sites, improving therapy effects and reducing unnecessary side effects. Metal–organic frameworks (MOFs), the typical nanoparticles, a class of crystalline porous materials via self-assembled organic linkers and metal ions, exhibit excellent biodegradability, pore shape and sizes, and finely tunable chemical composition. MOFs have a rigid molecular structure, and tunable pore size can improve the encapsulation drug's stability under harsh conditions. Besides, the surface of MOFs can be modified with small-molecule ligands and biomolecule, and binding with the biomarkers which is overexpressed on the surface of cancer cells. MOFs formulations for therapeutic have been developed to effectively respond to the unique tumor microenvironment (TEM), such as high H2O2 levels, hypoxia, and high concentration glutathione (GSH). Thus, MOFs as a drug delivery system should avoid drugs leaking during blood circulation and releasing at the lesion sites via a controlling manner. In this article, we will summary environment responsive MOFs as drug delivery systems for tumor therapy under different stimuli.

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A REVIEW ON FAST DISSOLVING TABLET

Journal of Drug Delivery and Therapeutics ◽

10.22270/jddt.v8i5.1888 ◽

2018 ◽

Vol 8 (5) ◽

pp. 50-55 ◽

Cited By ~ 4

Author(s):

RD Rahane ◽

Punit R. Rachh

Keyword(s):

Drug Delivery ◽

Drug Delivery System ◽

Patient Compliance ◽

Delivery System ◽

New Technologies ◽

Oral Drug Delivery ◽

Oral Drug ◽

Preparation Methods ◽

Orally Disintegrating Tablets ◽

Increasing Demand

The convenience of administration and improved patient compliance are important in the design of oral drug delivery system which remains the preferred route of drug delivery inspite of various disadvantages. Fast disintegrating tablets (FDTs) have received ever-increasing demand during the last decade, and the field has become a rapidly growing area in the pharmaceutical industry. The popularity and usefulness of the formulation resulted in development of several FDT technologies. These techniques render the disintegration of tablet rapidly and dissolve in mouth in five seconds without chewing and the need of water which is advantageous mainly for pediatrics, geriatrics and patients having difficulty in swallowing tablets and capsules. Formulation of a convenient dosage form for administration, by considering swallowing difficulty and poor patient compliance, leads to development of orally disintegrating tablets. Conventional preparation methods are spray drying, freeze drying, direct compression, Molding, and sublimation while new technologies have been developed for the production of orodispersible tablets. Keywords: Fast Dissolving Tablet, drug delivery system, fast disintegrating, fast melting.

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Budesonide self-nanoemulsion formulation as an oral drug delivery system: preparation, characterization and cytotoxicity studies

Pressacademia ◽

10.17261/pressacademia.2017.569 ◽

2017 ◽

Vol 5 (1) ◽

pp. 41-46

Author(s):

Burcu Mesut ◽

Seyma Hande Tekarslan-Sahin ◽

Yıldız Ozsoy

Keyword(s):

Drug Delivery ◽

Drug Delivery System ◽

Delivery System ◽

Oral Drug Delivery ◽

Oral Drug ◽

Oral Drug Delivery System ◽

Cytotoxicity Studies

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β-lactoglobulin-pectin Nanoparticle-based Oral Drug Delivery System for Potential Treatment of Colon Cancer

Chemical Biology & Drug Design ◽

10.1111/cbdd.12748 ◽

2016 ◽

Vol 88 (2) ◽

pp. 209-216 ◽

Cited By ~ 39

Author(s):

Zhila Izadi ◽

Adeleh Divsalar ◽

Ali Akbar Saboury ◽

Lindsay Sawyer

Keyword(s):

Drug Delivery ◽

Colon Cancer ◽

Drug Delivery System ◽

Delivery System ◽

Oral Drug Delivery ◽

Oral Drug ◽

Potential Treatment ◽

Oral Drug Delivery System ◽

Β Lactoglobulin

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REVIEW ON GASTRORETENTIVE DRUG DELIVERY SYSTEM

Asian Journal of Pharmaceutical and Clinical Research ◽

10.22159/ajpcr.2020.v13i12.37264 ◽

2020 ◽

pp. 38-45

Author(s):

MANDAR J BHANDWALKAR ◽

PRASAD S DUBAL ◽

AKASH K.TUPE ◽

SUPRIYA N MANDRUPKAR

Keyword(s):

Drug Delivery ◽

Small Intestine ◽

Drug Delivery System ◽

Residence Time ◽

Delivery System ◽

Oral Drug Delivery ◽

Dosage Forms ◽

Oral Dosage ◽

Oral Drug ◽

Low Solubility

In recent years, gastroretentive drug delivery system (GRDDS) has gained researcher’s interest in the field of oral drug delivery. Various GRDDS approaches can be utilized to retain the dosage forms in the stomach and to release the drug slowly for an extended period of time. GRDDS can be used to prolong the residence time of delivery system in the stomach. This results in targeting of drug release at a specific site for the systemic or local effects. GRDDS can be used to overcome challenges associated with conventional oral dosage forms and to release the drug at a specific absorption site to improve bioavailability of particular drug substance. The challenges include fast gastric emptying of the dosage form which results in the poor bioavailability of the drug. Prolongation of the retention of drugs in stomach those having low solubility at high intestinal pH improves the solubility of drugs. GRDDS has proved to be effective in systemic actions as well as in local actions to treat gastric or duodenal ulcers. Local activity in the upper part of the small intestine can be obtained by improving the residence time of delivery system in the stomach. The system is useful for drugs which are unstable in the intestine or having a low solubility/permeability in the small intestine. Various GRDDS approaches include high density (sinking) systems, low-density (floating systems), mucoadhesive, expandable, unfoldable, superporous hydrogel systems, and magnetic systems.

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