Core–shell nanostructures: perspectives towards drug delivery applications

The potential of nanotechnology in the biomedical field has been crucial for contributing to the possibility of efficiently meeting present necessities with novel materials. Over the last few decades, nanostructures with a core/shell structure have attracted significant attention because of the possibility of changing their physical properties by varying their chemistry and geometry. These structures have become relevant in targeted therapy (drug delivery and treatments to complement chemotherapy and radiotherapy), imaging and in the stimulation of cellular functions. Thus in this paper the current development of core/shell nanostructures is reviewed, emphasizing the physical properties of those that have been proposed as potentially having biomedical applications, which are based in a magnetic behavior or in a mixture of magnetic and electric (multiferroic) phenomena.

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Facile and greener hydrothermal honey‐based synthesis of Fe 3 O 4 /Au core/shell nanoparticles for drug delivery applications

Journal of Cellular Biochemistry ◽

10.1002/jcb.27958 ◽

2018 ◽

Vol 120 (4) ◽

pp. 6624-6631 ◽

Cited By ~ 3

Author(s):

Elisa Rasouli ◽

Wan Jeffrey Basirun ◽

Mohd Rafie Johan ◽

Majid Rezayi ◽

Majid Darroudi ◽

...

Keyword(s):

Drug Delivery ◽

Core Shell ◽

Shell Nanoparticles ◽

Drug Delivery Applications ◽

Core Shell Nanoparticles

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Magnetite-Silica Core/Shell Nanostructures: From Surface Functionalization towards Biomedical Applications—A Review

Applied Sciences ◽

10.3390/app112211075 ◽

2021 ◽

Vol 11 (22) ◽

pp. 11075

Author(s):

Angela Spoială ◽

Cornelia-Ioana Ilie ◽

Luminița Narcisa Crăciun ◽

Denisa Ficai ◽

Anton Ficai ◽

...

Keyword(s):

Magnetite Nanoparticles ◽

Biomedical Applications ◽

Sol Gel ◽

Magnetic Nanomaterials ◽

Core Shell ◽

Synthesis Methods ◽

Shell Nanostructures ◽

Silica Core ◽

Magnetic Resonance Imaging Mri ◽

Co Precipitation

The interconnection of nanotechnology and medicine could lead to improved materials, offering a better quality of life and new opportunities for biomedical applications, moving from research to clinical applications. Magnetite nanoparticles are interesting magnetic nanomaterials because of the property-depending methods chosen for their synthesis. Magnetite nanoparticles can be coated with various materials, resulting in “core/shell” magnetic structures with tunable properties. To synthesize promising materials with promising implications for biomedical applications, the researchers functionalized magnetite nanoparticles with silica and, thanks to the presence of silanol groups, the functionality, biocompatibility, and hydrophilicity were improved. This review highlights the most important synthesis methods for silica-coated with magnetite nanoparticles. From the presented methods, the most used was the Stöber method; there are also other syntheses presented in the review, such as co-precipitation, sol-gel, thermal decomposition, and the hydrothermal method. The second part of the review presents the main applications of magnetite-silica core/shell nanostructures. Magnetite-silica core/shell nanostructures have promising biomedical applications in magnetic resonance imaging (MRI) as a contrast agent, hyperthermia, drug delivery systems, and selective cancer therapy but also in developing magnetic micro devices.

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TPAOH assisted size-tunable Gd2O3@mSi core–shell nanostructures for multifunctional biomedical applications

Chemical Communications ◽

10.1039/c7cc07975c ◽

2018 ◽

Vol 54 (7) ◽

pp. 747-750 ◽

Cited By ~ 11

Author(s):

E. Pavitra ◽

G. Seeta Rama Raju ◽

Ganji Purnachandra Nagaraju ◽

Goli Nagaraju ◽

Young-Kyu Han ◽

...

Keyword(s):

Biomedical Applications ◽

Cancer Imaging ◽

Core Shell ◽

Shell Nanostructures

The synthesized size-tunable Gd2O3@mSi core–shell nanostructures are nontoxic and highly suitable as targeting materials for cancer imaging and therapy.

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Nanoformulations of core–shell type hydroxyapatite-coated gum acacia with enhanced bioactivity and controlled drug delivery for biomedical applications

New Journal of Chemistry ◽

10.1039/d0nj00668h ◽

2020 ◽

Vol 44 (17) ◽

pp. 7175-7185 ◽

Cited By ~ 3

Author(s):

Varun Prasath Padmanabhan ◽

Subha Balakrishnan ◽

Ravichandran Kulandaivelu ◽

Sankara Narayanan T. S. N. ◽

Muthukrishnan Lakshmipathy ◽

...

Keyword(s):

Drug Delivery ◽

Antibacterial Activity ◽

Biomedical Applications ◽

Controlled Drug Delivery ◽

Core Shell ◽

Gum Acacia ◽

Shell Type

In this work, nanospherical hydroxyapatite (HAP) was prepared that has combined properties of controlled drug delivery, biocompatibility, and antibacterial activity to have applications in the biomedical sector.

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