Discussion on the Governance Structure of "Transitional Communities" and Its Countermeasures Under Meta-Governance

With the continuous advancement of urban-rural integration, the scale of urban construction continues to expand, and a "transitional community" between the city and the countryside appears in response. The simple transformation of countryside from a traditional village form to a modern community is also accompanied by some contradictions and difficulties in structural transformation. In the discussion of "transitional community" governance, this paper analyzes the structure of transitional community under the premise of "meta-governance" theory, and proposes corresponding countermeasures to the problems of "transitional community" under the background of modern society.

F*: an interpretable transformation of the F-measure

The F-measure, also known as the F1-score, is widely used to assess the performance of classification algorithms. However, some researchers find it lacking in intuitive interpretation, questioning the appropriateness of combining two aspects of performance as conceptually distinct as precision and recall, and also questioning whether the harmonic mean is the best way to combine them. To ease this concern, we describe a simple transformation of the F-measure, which we call $$F^*$$ F ∗ (F-star), which has an immediate practical interpretation.

On the transformation of MinHash-based uncorrected distances into proper evolutionary distances for phylogenetic inference

Recently developed MinHash-based techniques were proven successful in quickly estimating the level of similarity between large nucleotide sequences. This article discusses their usage and limitations in practice to approximating uncorrected distances between genomes, and transforming these pairwise dissimilarities into proper evolutionary distances. It is notably shown that complex distance measures can be easily approximated using simple transformation formulae based on few parameters. MinHash-based techniques can therefore be very useful for implementing fast yet accurate alignment-free phylogenetic reconstruction procedures from large sets of genomes. This last point of view is assessed with a simulation study using a dedicated bioinformatics tool.

Why is There Lalangue Rather than Nothing? Love of Lugha and Lalangue

The chapter argues that the work on lugha in the late nineteenth-century was driven by the need to hold laghuw at bay. Lugha in its etymology carries the meaning of laghuw: incoherent speech, babble and error.6 In Bustānī’s nineteenth-century Arabic dictionary, it also has the meaning of annulment, erasure and deletion. To be in a state of laghuw is ‘to drink endlessly without being able to quench thirst’.7 In other words, lugha oscillates between pleasure and beyond pleasure, an identifiable object of desire that it constantly addresses and makes present through speech. This would mean that lalangue would represent an adequate translation of lugha – not language as a medium for communication, but the language of the unconscious, in which there is no simple transformation of words into images (or signifier into signified). The chapter analyzes Shidyaq’s linguisteriks through a Lacanian understanding of signification which departs from both socio-linguistics and structural linguistics. Lacan’s account of language as a divisive force implies that there is something that demands to be realised in speech, which appears as intentional, of course, but has a strange temporality and does not have the form of propositional statements. The chapter argues that Bustani’s encyclopedic work and Shidyaq’s literary puns are connected by a prolepsis that characterizes modernity and collapses the distance between science and literature.

Synthesis of Substituted imidazo [1, 5-a] pyrimidine-2-(1H)-one Core Structure

Background and Objective: The objective of our work was to establish a facile and scalable synthesis of imidazopyridone for further use in medicinal chemistry applications. An easy synthesis of a core scaffold will enable the medicinal chemistry community to use imidazopyridone as a privileged scaffold in new chemical entity (NCE) synthesis. Materials and Methods: The synthesis was achieved from commercially available and cheap raw materials like amino acetonitrile hydrochloride or commercially available guanidine. Results: Simple transformation starting from amino acetonitrile hydrochloride leads to the synthesis of a versatile imidazo [1, 5-a] pyrimidine-2-(1H)-one core structure. Using suitable functionalized starting materials, a set of NCEs were synthesized to demonstrate the application of the developed synthetic scheme. Similarly, guanidine was also used to synthesize a regioisomer of imidazopyridone in moderate to good yields. Conclusion: We demonstrate the synthesis of two different regio-isomers of imidazopyrimidinone using simple chemical transformations. Its application in synthesizing NCEs has also been exhibited in the present work.

Beyond the Tebbe Olefination: Direct Transformation of Esters into Ketones or Alkenes

A direct, effective, and operationally simple transformation of esters into ketones or alkenes by the exclusive action of Tebbe’s reagent has been developed. The transformation utilizes the dual character of Tebbe’s reagent as both a methylenation agent and a rearrangement catalyst in the reaction of a wide range of substituted vinyl ethers. The resulting transformation involves sequential methylenation and rearrangement reactions and it offers a high degree of selectivity toward the synthesis of ketones or alkenes. The scope and limitations of the developed methods have been also examined.

FLASHDeconv: Ultrafast, high-quality feature deconvolution for top-down proteomics

Feature deconvolution, the determination of intact proteoform masses, is crucial for top-down proteomics, but currently suffers from long runtimes and quality issues. We present FLASHDeconv, an algorithm based on a simple transformation of mass spectra, which turns deconvolution into the search for constant patterns thus greatly accelerating the process. We show higher deconvolution quality and two to three orders of magnitude faster execution speed than existing approaches.