F,N-doped carbon dot as an efficient Type I photosensitizer for photodynamic therapy

2022 ◽  
Author(s):  
Xiaoyan Wu ◽  
Mingsheng Xu ◽  
Shuna Wang ◽  
Khurram Abbas ◽  
Xin Huang ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Type I ◽  
Type Ii ◽  
Carbon Dot ◽  
Efficient Type

Photodynamic therapy (PDT) is a promising and emerging method for the treatment of cancer, usually Type II PDT is used in the clinic, which is mainly consists of three key...

scholarly journals Type I and Type II mechanisms of antimicrobial photodynamic therapy: An in vitro study on gram-negative and gram-positive bacteria

2012 ◽  
Vol 44 (6) ◽  
pp. 490-499 ◽  
Author(s):  
Liyi Huang ◽  
Yi Xuan ◽  
Yuichiro Koide ◽  
Timur Zhiyentayev ◽  
Masamitsu Tanaka ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
In Vitro Study ◽  
Vitro Study ◽  
Type I ◽  
Antimicrobial Photodynamic Therapy ◽  
Type Ii ◽  
Gram Positive ◽  
Gram Negative ◽  
Gram Positive Bacteria

Dual Fenton Catalytic Nanoreactor for Integrative Type-I and Type-II Photodynamic Therapy Against Hypoxic Cancer Cells

2019 ◽  
Vol 2 (9) ◽  
pp. 3854-3860 ◽  
Author(s):  
Xiao Cui ◽  
Jinfeng Zhang ◽  
Yingpeng Wan ◽  
Fang Fang ◽  
Rui Chen ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Cancer Cells ◽  
Type I ◽  
Type Ii

A Highly‐Efficient Type I Photosensitizer with Robust Vascular‐Disruption Activity for Hypoxic‐and‐Metastatic Tumor Specific Photodynamic Therapy

Small ◽  
2020 ◽  
Vol 16 (23) ◽  
pp. 2001059 ◽  
Author(s):  
Dapeng Chen ◽  
Qing Yu ◽  
Xuan Huang ◽  
Hanming Dai ◽  
Tao Luo ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Metastatic Tumor ◽  
Type I ◽  
Highly Efficient ◽  
Vascular Disruption ◽  
Efficient Type

scholarly journals PHOTODYNAMIC THERAPY: NEW LIGHT IN MEDICINE WORLD

2010 ◽  
Vol 8 (2) ◽  
pp. 279-291 ◽  
Author(s):  
Venny Santosa ◽  
Leenawaty Limantara
Keyword(s):  
Reactive Oxygen Species ◽  
Photodynamic Therapy ◽  
Side Effects ◽  
Reactive Oxygen Species Generation ◽  
Reactive Oxygen ◽  
Type I ◽  
Oxygen Species ◽  
Type Ii ◽  
Light Spectrum ◽  
Medical Field

Photodynamic therapy (PDT) is a considerably new kind of photochemotherapeutic treatment in medical field. It combines the use of three components, which are a photosensitizer, light and oxygen. Photosensitizer is a compound activated by light. The application can be oral, topical or intravenous. It usually member of porphyrin group with ampiphilic characteristics. Photosensitizer can be of generation I, II or III, each generation step develops more specificity, selectivity and deeper tissue application. This review will discuss photosensitizer development consecutively, with its benefit and lackness. The light used is usually on red region, while the oxygen is involved in reactive oxygen species generation. Its mechanism action can go through either in type I or type II reaction. This kind of therapy is usually being used in oncology, especially in superficial and in-lining cancers, dermatology and ophthalmology field. This therapy can be safely given to patients with complication and has distinct advantages compare with other treatment such as chemotherapy and surgery. It also considerably has lesser side effects and risks. Broader application is being developed through various experiments and photosensitizer modification.   Keywords: light spectrum, photoactivation, photodynamic therapy, photosensitizer

Nanoscale Metal–Organic Frameworks Stabilize Bacteriochlorins for Type I and Type II Photodynamic Therapy

2020 ◽  
Vol 142 (16) ◽  
pp. 7334-7339 ◽  
Author(s):  
Taokun Luo ◽  
Kaiyuan Ni ◽  
August Culbert ◽  
Guangxu Lan ◽  
Zhe Li ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Metal Organic Frameworks ◽  
Type I ◽  
Type Ii ◽  
Metal Organic

Ground- and excited-state interactions of 2,7,12,17-tetraphenylporphycene with model target biomolecules for type-I photodynamic therapy

2009 ◽  
Vol 13 (01) ◽  
pp. 99-106 ◽  
Author(s):  
Noemí Rubio ◽  
Víctor Martínez-Junza ◽  
Jordi Estruga ◽  
José I. Borrell ◽  
Margarita Mora ◽  
...  
Keyword(s):  
Electron Transfer ◽  
Photodynamic Therapy ◽  
Excited State ◽  
Singlet Oxygen ◽  
Cell Lines ◽  
Mechanism Of Action ◽  
Photophysical Properties ◽  
Type I ◽  
Type Ii ◽  
Hydrophobic Compound

Biosubstrate-sensitizer binding is one of the factors that enhances the type-I mechanism over the type-II in the whole photodynamic process. 2,7,12,17-Tetraphenylporphycene (TPPo), a second-generation photosensitizer, is a hydrophobic compound with good photophysical properties for photodynamic therapy applications that has proved its ability for the photoinactivation of different cell lines. Nevertheless, little is known about its mechanism of action. This paper focuses on the study of the interaction/binding of TPPo with different model biomolecules that may favor the type-I mechanism in the overall photodynamic process, including nucleosides, proteins, and phospholipids. Compared with more hydrophilic photosensitizers, it is concluded that TPPo is more likely to undergo type-II (singlet oxygen) than type-I (electron transfer) photodynamic processes in biological environments.

Cationization to boost both type I and type II ROS generation for photodynamic therapy

Biomaterials ◽  
2021 ◽  
pp. 121255
Author(s):  
Yuewen Yu ◽  
Shuang Wu ◽  
Le Zhang ◽  
Shidang Xu ◽  
Chunhui Dai ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Ros Generation ◽  
Type I ◽  
Type Ii

Molten Salt Synthesis of Nitrogen Doped Carbon Nanoparticles for Enhanced Type-I Photodynamic Therapy

2021 ◽  
Author(s):  
Fu Wang ◽  
Zhi Su ◽  
Yanan Tian ◽  
Yuxin Huang ◽  
Xiaoyu Huang
Keyword(s):  
Photodynamic Therapy ◽  
Molten Salt ◽  
Carbon Nanoparticles ◽  
Tumor Hypoxia ◽  
Molten Salt Synthesis ◽  
Type I ◽  
Type Ii ◽  
Nitrogen Doped ◽  
Nitrogen Doped Carbon ◽  
Dependent Type

Photodynamic therapy has received widespread attention in antitumor application. However, the tumor hypoxia microenvironment seriously suppresses the treatment efficience, especially for these oxygen-dependent type-II systems. Herein, novel nitrogen-doped carbon nanoparticles...

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