Two decades of recent advances of Passerini reactions: synthetic and potential pharmaceutical applications

2022 ◽  
Author(s):  
Yasmin Wahby ◽  
Hamida Abdel-Hamid ◽  
Mohammed Salah Ayoup

This perspective describes the applications of Passerini reactions in the last two decades from 2000 to 2021 in pharmaceutical applications and synthesis of peptides, natural products, macrocycles, dendrimers, and versatile types of heterocycles.

RSC Advances ◽  
2020 ◽  
Vol 10 (70) ◽  
pp. 42644-42681
Author(s):  
Manar Ahmed Fouad ◽  
Hamida Abdel-Hamid ◽  
Mohammed Salah Ayoup

We highlight the recent advances of the Ugi reaction in the last two decades from 2000–2019, mainly in the synthesis of linear or cyclic peptides, heterocyclic compounds with versatile ring sizes, and natural products, as well as the enantioselective Ugi reactions.


ChemInform ◽  
2010 ◽  
Vol 30 (21) ◽  
pp. no-no
Author(s):  
K. C. Nicolaou ◽  
M. H. D. Postema ◽  
N. D. Miller

2010 ◽  
Vol 27 (12) ◽  
pp. 1781 ◽  
Author(s):  
Inder Pal Singh ◽  
Hardik S. Bodiwala

2018 ◽  
Vol 5 (6) ◽  
pp. 1049-1066 ◽  
Author(s):  
Yingbo Shi ◽  
Qiaoling Wang ◽  
Shuanhu Gao

This review focuses on selected applications of the intramolecular Mannich reaction as a key step in the total synthesis of natural products (2000–2017).


2022 ◽  
Author(s):  
Loleny Tavares ◽  
Slim SMAOUI ◽  
Cristian Pinilla ◽  
Hajer Ben Hlima ◽  
Helio Lopes Barros

Recently, studies on natural products have considerably increased due to their exceptional biological activities and health benefits. Subsequently, their pharmacological attributes have played an immense role in detecting natural and...


Molecules ◽  
2020 ◽  
Vol 25 (14) ◽  
pp. 3247 ◽  
Author(s):  
Carlos Santiago ◽  
Nuria Sotomayor ◽  
Esther Lete

Di(hetero)aryl ketones are important motifs present in natural products, pharmaceuticals or agrochemicals. In recent years, Pd(II)-catalyzed acylation of (hetero)arenes in the presence of an oxidant has emerged as a catalytic alternative to classical acylation methods, reducing the production of toxic metal waste. Different directing groups and acyl sources are being studied for this purpose, although further development is required to face mainly selectivity problems in order to be applied in the synthesis of more complex molecules. Selected recent developments and applications are covered in this review.


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