Ginger: A systematic review of clinical trials and recent advances encapsulation of their bioactive compounds

2022 ◽  
Author(s):  
Loleny Tavares ◽  
Slim SMAOUI ◽  
Cristian Pinilla ◽  
Hajer Ben Hlima ◽  
Helio Lopes Barros
Keyword(s):  
Systematic Review ◽  
Clinical Trials ◽  
Natural Products ◽  
Bioactive Compounds ◽  
Biological Activities ◽  
Health Benefits ◽  
Recent Advances

Recently, studies on natural products have considerably increased due to their exceptional biological activities and health benefits. Subsequently, their pharmacological attributes have played an immense role in detecting natural and...

scholarly journals Chemical Diversity and Biological Activity of Secondary Metabolites Isolated from Indonesian Marine Invertebrates

Molecules ◽  
2021 ◽  
Vol 26 (7) ◽  
pp. 1898
Author(s):  
Fauzia Izzati ◽  
Mega Ferdina Warsito ◽  
Asep Bayu ◽  
Anggia Prasetyoputri ◽  
Akhirta Atikana ◽  
...  
Keyword(s):  
Natural Products ◽  
Bioactive Compounds ◽  
Marine Natural Products ◽  
Biological Function ◽  
Marine Invertebrates ◽  
Biological Activities ◽  
Structural Diversity ◽  
Chemical Diversity ◽  
Soft Corals ◽  
High Chemical

Marine invertebrates have been reported to be an excellent resource of many novel bioactive compounds. Studies reported that Indonesia has remarkable yet underexplored marine natural products, with a high chemical diversity and a broad spectrum of biological activities. This review discusses recent updates on the exploration of marine natural products from Indonesian marine invertebrates (i.e., sponges, tunicates, and soft corals) throughout 2007–2020. This paper summarizes the structural diversity and biological function of the bioactive compounds isolated from Indonesian marine invertebrates as antimicrobial, antifungal, anticancer, and antiviral, while also presenting the opportunity for further investigation of novel compounds derived from Indonesian marine invertebrates.

Hemoglobin F (HbF) inducers; History, Structure and Efficacies

2021 ◽  
Vol 21 ◽  
Author(s):  
Zahra Hashemi ◽  
Mohammad Ali Ebrahimzadeh
Keyword(s):  
Clinical Trials ◽  
Natural Products ◽  
Biological Activities ◽  
Globin Gene ◽  
Beta Thalassemia ◽  
Gene Promoters ◽  
Hemoglobin F ◽  
Chemical Structures

Abstract: Inherited beta-thalassemia is a major disease caused by irregular production of hemoglobin through reducing beta-globin chains. It has been observed that increasing fetal hemoglobin (HbF) production improves symptoms in the patients. Therefore, an increase in the level of HbF has been an operative approach for treating patients with beta-thalassemia. This review represents compounds with biological activities and pharmacological properties that can promote the HBF level and therefore used in the β-thalassemia patients' therapy. Various natural products with different mechanisms of action can be helpful in this medication cure. Clinical trials were efficient in improving the signs of patients. Association of in vivo, and in vitro studies of HbF induction and γ-globin mRNA growth displays that in vitro experiments could be an indicator of the in vivo response. The current study shows that; (a) HbF inducers can be grouped in several classes based on their chemical structures and mechanism of actions; b) According to several clinical trials, well-known drugs such as hydroxyurea and decitabine are useful HbF inducers; (c) The cellular biosensor K562 carrying genes under the control of the human γ-globin and β-globin gene promoters were applied during the researches; d) New natural products and lead compounds were found based on various studies as HbF inducers.

scholarly journals Leonurine, a Potential Agent of Traditional Chinese Medicine: Recent Updates and Future Perspectives

2016 ◽  
Vol 11 (11) ◽  
pp. 1934578X1601101 ◽  
Author(s):  
Di Yang ◽  
Wanwan Jia ◽  
Yi Zhun Zhu
Keyword(s):  
Natural Products ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Therapeutic Potential ◽  
Biological Activities ◽  
Future Perspectives ◽  
Effective Agent ◽  
Recent Advances

Herba Leonuri, also named Chinese Motherwort, has been extensively investigated as an effective agent on the uterus system. Our group has been studying the natural products of Herba Leonuri for several years, and during this period, many biological activities of the drug were recognized. Leonurine (4-guanidino- N-butyl-syringate) is an alkaloid present in Herba Leonuri. Recently, growing evidence has highlighted the therapeutic potential of leonurine in multiple diseases, especially cardiovascular. In this review, we discuss the biological activities of leonurine, as well as recent advances involving this alkaloid.

scholarly journals The endemic plants – a valuable resource with vast potential in Bulgaria: A brief overview

2021 ◽  
Vol 13 (3) ◽  
pp. 219-233
Author(s):  
D.T. Petkova ◽  
D.Sp. Mihaylova
Keyword(s):  
Natural Products ◽  
Natural Product ◽  
Bioactive Compounds ◽  
Biological Activities ◽  
Endemic Plants ◽  
Valuable Resource ◽  
Plant Kingdom ◽  
Mountainous Regions ◽  
Biological Compounds ◽  
Prevention And Treatment

Abstract. The plant kingdom with its natural products, both terrestrial and marine, has been widely studied. Plant-based products have long been used for the prevention and treatment of various diseases. Many natural compounds are reported to have a number of interesting and significant biological activities, such as antioxidant, anti-inflammatory, antitumor, antibacterial, antiviral, antifungal, antiparasitic, analgesic, antidiabetic, antiatherogenic, antiproliferative, and cardioprotective and neuroprotective activities. In order to find a natural product, researchers often explore the possibilities given by nature. Special attention is paid to bioactive compounds synthesized by endemic plants as a specific resource of limited habitat. This review focuses on a brief overview of endemic plants in Bulgaria, most common in the mountainous regions of the country, with the aim to encourage the knowledge of these resources with vast potential for unique biological compounds and specific characteristics beneficial to humans for various purposes.

scholarly journals Metabolites from Marine Microorganisms, Micro, and Macroalgae: Immense Scope for Pharmacology

Marine Drugs ◽  
2019 ◽  
Vol 17 (8) ◽  
pp. 464 ◽  
Author(s):  
Barzkar ◽  
Tamadoni Jahromi ◽  
Poorsaheli ◽  
Vianello
Keyword(s):  
Clinical Trials ◽  
Natural Products ◽  
Drug Discovery ◽  
Biological Activities ◽  
Marine Organisms ◽  
Large Array ◽  
New Wave ◽  
Marine Microorganisms ◽  
Marine Metabolites ◽  
Advanced Stages

Marine organisms produce a large array of natural products with relevance in drug discovery. These compounds have biological activities such as antioxidant, antibacterial, antitumor, antivirus, anticoagulant, anti-inflammatory, antihypertensive, antidiabetic, and so forth. Consequently, several of the metabolites have made it to the advanced stages of clinical trials, and a few of them are commercially available. In this review, novel information on natural products isolated from marine microorganisms, microalgae, and macroalgae are presented. Given due research impetus, these marine metabolites might emerge as a new wave of promising drugs.

Recent Advances in the Synthesis of Thiadiazoles

Synlett ◽  
2019 ◽  
Vol 30 (18) ◽  
pp. 2041-2050
Author(s):  
Yan Xiao ◽  
Song Sun ◽  
Jin-Tao Yu ◽  
Jiang Cheng
Keyword(s):  
Natural Products ◽  
Broad Spectrum ◽  
Biological Activities ◽  
Pharmaceutical Compounds ◽  
Antifungal Drugs ◽  
The Past ◽  
Recent Advances

Thiadiazole moieties are present in many natural products and pharmaceutical compounds that possess a broad spectrum of biological activities, serving as antidepressant, anxiolytic, antimicrobial, antitubercular, antiinflammatory, antidiabetic, anticancer, antihypertensive, or antifungal drugs. Many excellent methods have been reported for accessing such frameworks. In this review, we summarize advances made within the past ten years in the synthesis of various types of thiadiazole.1 Introduction2 Synthesis of Thiadiazoles2.1 Synthesis of 1,2,3-Thiadiazoles2.1.1 Synthesis of 1,2,3-Thiadiazoles from Diazo/Azide Compounds2.1.2 Synthesis of 1,2,3-Thiadiazoles from Sulfonyl Hydrazines or N-Tosylhydrazones2.2 Synthesis of 1,2,4-Thiadiazoles2.2.1 Synthesis of 1,2,4-Thiadiazoles from Thioamides or their Derivatives2.2.2 Synthesis of 1,2,4-Thiadiazoles from Amidines or 2-Aminopyridines2.3 Synthesis of 1,3,4-Thiadiazoles2.4 Synthesis of 1,2,5-Thiadiazoles3 Conclusion

scholarly journals Marine Natural Products, Multitarget Therapy and Repurposed Agents in Alzheimer’s Disease

2020 ◽  
Vol 13 (9) ◽  
pp. 242
Author(s):  
Márcia Martins ◽  
Renata Silva ◽  
Madalena M. M. Pinto ◽  
Emília Sousa
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Clinical Trials ◽  
Natural Products ◽  
Marine Natural Products ◽  
Biological Activities ◽  
Drug Repurposing ◽  
Phase Iii ◽  
Pharmacological Agents ◽  
Chemical Structures

Alzheimer’s disease (AD) is a multifactorial disease characterized by the presence of amyloid plaques, neurofibrillary tangles, and nerve cell death that affects, mainly, older people. After decades of investigation, the search for an efficacious treatment for AD remains and several strategies can be and are being employed in this journey. In this review, four of the most promising strategies, alongside with its most promising agents under investigation or development are highlighted. Marine natural products (MNP) are a source of unique chemical structures with useful biological activities for AD treatment. One of the most promising compounds, a marine-derived acidic oligosaccharide (GV-971) just passed phase III clinical trials with a unique mechanism of action. Combination therapy and multitargeted-directed ligand therapy (MTDL) are also two important strategies, with several examples in clinical trials, based on the belief that the best approach for AD is a therapy capable of modulating multiple target pathways. Drug repurposing, a strategy that requires a smaller investment and is less time consuming, is emerging as a strong contender with a variety of pharmacological agents resurfacing in an attempt to identify a therapeutic candidate capable of modifying the course of this disease.

Recent advances for the synthesis of chiral sulfones with the sulfone moiety directly connected to the chiral center

2021 ◽  
Author(s):  
Chuanle Zhu ◽  
Yingying Cai ◽  
Huanfeng Jiang
Keyword(s):  
Natural Products ◽  
Bioactive Compounds ◽  
Building Blocks ◽  
Chiral Center ◽  
Recent Advances ◽  
Chiral Centers

Chiral sulfones, especially for those compounds with the sulfone groups directly connected to the chiral centers, are privileged building blocks in many natural products and bioactive compounds. Thus, the development...

scholarly journals Phytochemicals Derived from Catharanthus roseus and Their Health Benefits

Technologies ◽  
2020 ◽  
Vol 8 (4) ◽  
pp. 80
Author(s):  
Hong Ngoc Thuy Pham ◽  
Quan Van Vuong ◽  
Michael C. Bowyer ◽  
Christopher J. Scarlett
Keyword(s):  
Bioactive Compounds ◽  
Catharanthus Roseus ◽  
Anticancer Agents ◽  
Human Cancer ◽  
Biological Activities ◽  
Health Benefits ◽  
Traditional Use ◽  
Human Cancer Cell Lines ◽  
Promising Source

Catharanthus roseus (C. roseus) is an important medicinal plant distributed in many countries. It has attracted increasing attention due to it being shown to possess a range of phytochemicals with various biological activities such as antioxidant, antibacterial, antifungal, antidiabetic and anticancer properties. Remarkably, vinblastine and vincristine isolated from this plant were the first plant-derived anticancer agents deployed for clinical use. Recently, new isolated indole alkaloids from this plant including catharoseumine, 14′,15′-didehydrocyclovinblastine, 17-deacetoxycyclovinblastine and 17-deacetoxyvinamidine effectively inhibited human cancer cell lines in vitro. Moreover, vindoline, vindolidine, vindolicine and vindolinine isolated from C. roseus leaf exhibited in vitro antidiabetic property. These findings strongly indicate that this plant is still a promising source of bioactive compounds, which should be further investigated. This paper provides an overview of the traditional use and phytochemical profiles of C. roseus, and summarises updated techniques of the preparation of dried material, extraction and isolation of bioactive compounds from this plant. In addition, purported health benefits of the extracts and bioactive compounds derived from this plant were also addressed to support their potential as therapeutic agents.

scholarly journals Bioactive Compounds and Biological Activities of Sorghum Grains

Foods ◽  
2021 ◽  
Vol 10 (11) ◽  
pp. 2868
Author(s):  
Zhenhua Li ◽  
Xiaoyan Zhao ◽  
Xiaowei Zhang ◽  
Hongkai Liu
Keyword(s):  
Clinical Trials ◽  
Phenolic Compounds ◽  
Bioactive Compounds ◽  
Biological Activities ◽  
In Vivo Studies ◽  
Detection Technology ◽  
Sorghum Grains ◽  
Bound Phenolics

Sorghum is the fifth most commonly used cereal worldwide and is a rich source of many bioactive compounds. We summarized phenolic compounds and carotenoids, vitamin E, amines, and phytosterols in sorghum grains. Recently, with the development of detection technology, new bioactive compounds such as formononetin, glycitein, and ononin have been detected. In addition, multiple in vitro and in vivo studies have shown that sorghum grains have extensive bio-logical activities, such as antioxidative, anticancer, antidiabetic, antiinflammatory, and antiobesity properties. Finally, with the establishment of sorghum phenolic compounds database, the bound phenolics and their biological activities and the mechanisms of biological activities of sorghum bioactive compounds using clinical trials may be researched.

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