Reversible assembly-disassembly of plasmonic spherical nucleic acid enabling temperature-self-controllable and biomarker-activatable photothermal effect

2021 ◽  
Author(s):  
Lixian Huang ◽  
Jinling Zhang ◽  
Lifang Pang ◽  
Shengqiang Hu ◽  
Liangliang Zhang ◽  
...  
Keyword(s):  
Nucleic Acid ◽  
Nucleic Acids ◽  
Melting Temperature ◽  
Self Assembly ◽  
The Self ◽  
Photothermal Effect ◽  
Spherical Nucleic Acid ◽  
Photothermal Heating ◽  
Spherical Nucleic Acids

Since the photothermal heating of plasmonic spherical nucleic acids (pSNAs) depended on the self-assembly level and melting temperature (Tm), temperature-self-controllable and biomarker-activatable photothermal effect in vivo was thus achieved using...

Transdermal Delivery of Poly-Hyaluronic Acid-Based Spherical Nucleic Acids for Chemogene Therapy

Nanoscale ◽  
2022 ◽  
Author(s):  
Kai Jiang ◽  
Di Zhao ◽  
Rui Ye ◽  
Xinlong Liu ◽  
Chao Gao ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Nucleic Acid ◽  
Gene Delivery ◽  
Nucleic Acids ◽  
Delivery System ◽  
Transdermal Delivery ◽  
Gene Delivery System ◽  
Transdermal Administration ◽  
Spherical Nucleic Acid ◽  
Spherical Nucleic Acids

Spherical nucleic acid (SNA), as a good gene delivery system, has a good application prospect for transdermal administration in skin disorders treatment. However, most of traditional SNA core materials are...

DNA nanoclew templated spherical nucleic acids for siRNA delivery

2018 ◽  
Vol 54 (29) ◽  
pp. 3609-3612 ◽  
Author(s):  
Weimin Ruan ◽  
Meng Zheng ◽  
Yang An ◽  
Yuanyuan Liu ◽  
David B. Lovejoy ◽  
...  
Keyword(s):  
Nucleic Acid ◽  
Nucleic Acids ◽  
Sirna Delivery ◽  
Dna Nanostructure ◽  
Spherical Nucleic Acid ◽  
Spherical Nucleic Acids

A superior biocompatible spherical nucleic acid (SNA) conjugate was fabricated by grafting siRNA onto the surface of a core composed of a spherical DNA nanostructure that we have termed DNA nanoclew (DC).

Re-Evaluating the Spherical-Nucleic-Acid Technology

2018 ◽  
Author(s):  
Maria Czarnek ◽  
David Mason ◽  
Gal Haimovich ◽  
Víctor F. Puntes ◽  
Paolo Bergese ◽  
...  
Keyword(s):  
Nucleic Acid ◽  
Nucleic Acids ◽  
Spherical Nucleic Acid ◽  
Spherical Nucleic Acids ◽  
In Cells

We re-evaluate the evidence presented for the detection of mRNA in cells and tissues with Spherical Nucleic Acids.<br>

Re-Evaluating the Spherical-Nucleic-Acid Technology

2018 ◽  
Author(s):  
Maria Czarnek ◽  
David Mason ◽  
Gal Haimovich ◽  
Víctor F. Puntes ◽  
Paolo Bergese ◽  
...  
Keyword(s):  
Nucleic Acid ◽  
Nucleic Acids ◽  
Spherical Nucleic Acid ◽  
Spherical Nucleic Acids ◽  
In Cells

We re-evaluate the evidence presented for the detection of mRNA in cells and tissues with Spherical Nucleic Acids.<br>

Re-Evaluating the Spherical-Nucleic-Acid Technology

2018 ◽  
Author(s):  
Maria Czarnek ◽  
David Mason ◽  
Gal Haimovich ◽  
Víctor F. Puntes ◽  
Paolo Bergese ◽  
...  
Keyword(s):  
Nucleic Acid ◽  
Nucleic Acids ◽  
Spherical Nucleic Acid ◽  
Spherical Nucleic Acids ◽  
In Cells

We re-evaluate the evidence presented for the detection of mRNA in cells and tissues with Spherical Nucleic Acids.<br>

Bioactive clusters promoting cell penetration and nucleic acid complexation for drug and gene delivery applications: from designed to self-assembled and responsive systems

2016 ◽  
Vol 52 (23) ◽  
pp. 4257-4273 ◽  
Author(s):  
Eline Bartolami ◽  
Camille Bouillon ◽  
Pascal Dumy ◽  
Sébastien Ulrich
Keyword(s):  
Nucleic Acid ◽  
Gene Delivery ◽  
Nucleic Acids ◽  
Self Assembly ◽  
The Self ◽  
Cell Penetration ◽  
Responsive Systems ◽  
Recent Developments ◽  
Self Assembled ◽  
Drug And Gene Delivery

Recent developments in the (self-)assembly of cationic clusters promoting nucleic acids complexation and cell penetration open the door to applications in drug and gene delivery.

pH-Responsive spherical nucleic acid for intracellular lysosome imaging and an effective drug delivery system

2018 ◽  
Vol 54 (28) ◽  
pp. 3520-3523 ◽  
Author(s):  
Hui Li ◽  
Xiang Zhou ◽  
Dongbao Yao ◽  
Haojun Liang
Keyword(s):  
Drug Delivery ◽  
Nucleic Acid ◽  
Nucleic Acids ◽  
Drug Delivery System ◽  
Delivery System ◽  
Effective Drug ◽  
Ph Responsive ◽  
Spherical Nucleic Acid ◽  
System P ◽  
Spherical Nucleic Acids

This study presents a class of pH-responsive spherical nucleic acids that can exactly image intracellular lysosomes and be an effective drug delivery system.

Re-Evaluating the Spherical-Nucleic-Acid Technology

2018 ◽  
Author(s):  
Maria Czarnek ◽  
David Mason ◽  
Gal Haimovich ◽  
Víctor F. Puntes ◽  
Paolo Bergese ◽  
...  
Keyword(s):  
Nucleic Acid ◽  
Nucleic Acids ◽  
Spherical Nucleic Acid ◽  
Spherical Nucleic Acids ◽  
In Cells

We re-evaluate the evidence presented for the detection of mRNA in cells and tissues with Spherical Nucleic Acids.<br>

IMMU-53. STING-ING GLIOBLASTOMA WITH SPHERICAL NUCLEIC ACIDS

2021 ◽  
Vol 23 (Supplement_6) ◽  
pp. vi104-vi105
Author(s):  
Akanksha Mahajan ◽  
Lisa Hurley ◽  
Serena Tommasini-Ghelfi ◽  
Corey Dussold ◽  
Alexander Stegh ◽  
...  
Keyword(s):  
Nucleic Acid ◽  
High Surface ◽  
Biological Properties ◽  
Innate Immune ◽  
Limiting Factors ◽  
Nucleic Acid Delivery ◽  
Sting Pathway ◽  
Spherical Nucleic Acids

Abstract The Stimulator of Interferon Genes (STING) pathway represents a major innate immune sensing mechanism for tumor-derived DNA. Modified cyclic dinucleotides (CDNs) that mimic the endogenous STING ligand cGAMP are currently being explored in patients with solid tumors that are amenable to intratumoral delivery. Inadequate bioavailability and insufficient lipophilicity are limiting factors for clinical CDN development, in particular when consideration is given to systemic administration approaches. We have shown that the formulation of oligonucleotides into Spherical Nucleic Acid (SNA) nanostructures, i.e.,the presentation of oligonucleotides at high density on the surface of nanoparticle cores, lead to biochemical and biological properties that are radically different from those of linear oligonucleotides. First-generation brain-penetrant siRNA-based SNAs (NCT03020017, recurrent GBM) have recently completed early clinical trials. Here, we report the development of a STING-agonistic immunotherapy by targeting cGAS, the sensor of cytosolic dsDNA upstream of STING, with SNAs presenting dsDNA at high surface density. The strategy of using SNAs exploits the ability of cGAS to raise STING responses by delivering dsDNA and inducing the catalytic production of endogenous CDNs. SNA nanostructures carrying a 45bp IFN-simulating dsDNA oligonucleotide, the most commonly used and widely characterized cGAS activator, potently activated the cGAS-STING pathway in vitro and in vivo. In a poorly immunogenic and highly aggressive syngeneic mouse glioma model, in which tumours were well-established, only one dose of intranasal treatment with STING-SNAs decelerated tumour growth, improved survival and importantly, was well-tolerated. Our use of SNAs addresses the challenges of nucleic acid delivery to intracranial tumor sites via intranasal route, exploits the binding of dsDNA molecules on the SNA surface to enhance the formation of a dimeric cGAS:DNA complex and establishes cGAS-agonistic SNAs as a novel class of immune-stimulatory modalities for triggering innate immune responses against tumor.

scholarly journals Defining the Design Parameters for in Vivo Enzyme Delivery Through Protein Spherical Nucleic Acids

2020 ◽  
Vol 6 (5) ◽  
pp. 815-822
Author(s):  
Caroline D. Kusmierz ◽  
Katherine E. Bujold ◽  
Cassandra E. Callmann ◽  
Chad A. Mirkin
Keyword(s):  
Nucleic Acids ◽  
Design Parameters ◽  
Spherical Nucleic Acids ◽  
Enzyme Delivery
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