Re-Evaluating the Spherical-Nucleic-Acid Technology

2018 ◽  
Author(s):  
Maria Czarnek ◽  
David Mason ◽  
Gal Haimovich ◽  
Víctor F. Puntes ◽  
Paolo Bergese ◽  
...  
Keyword(s):  
Nucleic Acid ◽  
Nucleic Acids ◽  
Spherical Nucleic Acid ◽  
Spherical Nucleic Acids ◽  
In Cells

We re-evaluate the evidence presented for the detection of mRNA in cells and tissues with Spherical Nucleic Acids.<br>

Re-Evaluating the Spherical-Nucleic-Acid Technology

2018 ◽  
Author(s):  
Maria Czarnek ◽  
David Mason ◽  
Gal Haimovich ◽  
Víctor F. Puntes ◽  
Paolo Bergese ◽  
...  
Keyword(s):  
Nucleic Acid ◽  
Nucleic Acids ◽  
Spherical Nucleic Acid ◽  
Spherical Nucleic Acids ◽  
In Cells

We re-evaluate the evidence presented for the detection of mRNA in cells and tissues with Spherical Nucleic Acids.<br>

Re-Evaluating the Spherical-Nucleic-Acid Technology

2018 ◽  
Author(s):  
Maria Czarnek ◽  
David Mason ◽  
Gal Haimovich ◽  
Víctor F. Puntes ◽  
Paolo Bergese ◽  
...  
Keyword(s):  
Nucleic Acid ◽  
Nucleic Acids ◽  
Spherical Nucleic Acid ◽  
Spherical Nucleic Acids ◽  
In Cells

We re-evaluate the evidence presented for the detection of mRNA in cells and tissues with Spherical Nucleic Acids.<br>

Re-Evaluating the Spherical-Nucleic-Acid Technology

2018 ◽  
Author(s):  
Maria Czarnek ◽  
David Mason ◽  
Gal Haimovich ◽  
Víctor F. Puntes ◽  
Paolo Bergese ◽  
...  
Keyword(s):  
Nucleic Acid ◽  
Nucleic Acids ◽  
Spherical Nucleic Acid ◽  
Spherical Nucleic Acids ◽  
In Cells

We re-evaluate the evidence presented for the detection of mRNA in cells and tissues with Spherical Nucleic Acids.<br>

Transdermal Delivery of Poly-Hyaluronic Acid-Based Spherical Nucleic Acids for Chemogene Therapy

Nanoscale ◽  
2022 ◽  
Author(s):  
Kai Jiang ◽  
Di Zhao ◽  
Rui Ye ◽  
Xinlong Liu ◽  
Chao Gao ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Nucleic Acid ◽  
Gene Delivery ◽  
Nucleic Acids ◽  
Delivery System ◽  
Transdermal Delivery ◽  
Gene Delivery System ◽  
Transdermal Administration ◽  
Spherical Nucleic Acid ◽  
Spherical Nucleic Acids

Spherical nucleic acid (SNA), as a good gene delivery system, has a good application prospect for transdermal administration in skin disorders treatment. However, most of traditional SNA core materials are...

DNA nanoclew templated spherical nucleic acids for siRNA delivery

2018 ◽  
Vol 54 (29) ◽  
pp. 3609-3612 ◽  
Author(s):  
Weimin Ruan ◽  
Meng Zheng ◽  
Yang An ◽  
Yuanyuan Liu ◽  
David B. Lovejoy ◽  
...  
Keyword(s):  
Nucleic Acid ◽  
Nucleic Acids ◽  
Sirna Delivery ◽  
Dna Nanostructure ◽  
Spherical Nucleic Acid ◽  
Spherical Nucleic Acids

A superior biocompatible spherical nucleic acid (SNA) conjugate was fabricated by grafting siRNA onto the surface of a core composed of a spherical DNA nanostructure that we have termed DNA nanoclew (DC).

Reversible assembly-disassembly of plasmonic spherical nucleic acid enabling temperature-self-controllable and biomarker-activatable photothermal effect

2021 ◽  
Author(s):  
Lixian Huang ◽  
Jinling Zhang ◽  
Lifang Pang ◽  
Shengqiang Hu ◽  
Liangliang Zhang ◽  
...  
Keyword(s):  
Nucleic Acid ◽  
Nucleic Acids ◽  
Melting Temperature ◽  
Self Assembly ◽  
The Self ◽  
Photothermal Effect ◽  
Spherical Nucleic Acid ◽  
Photothermal Heating ◽  
Spherical Nucleic Acids

Since the photothermal heating of plasmonic spherical nucleic acids (pSNAs) depended on the self-assembly level and melting temperature (Tm), temperature-self-controllable and biomarker-activatable photothermal effect in vivo was thus achieved using...

pH-Responsive spherical nucleic acid for intracellular lysosome imaging and an effective drug delivery system

2018 ◽  
Vol 54 (28) ◽  
pp. 3520-3523 ◽  
Author(s):  
Hui Li ◽  
Xiang Zhou ◽  
Dongbao Yao ◽  
Haojun Liang
Keyword(s):  
Drug Delivery ◽  
Nucleic Acid ◽  
Nucleic Acids ◽  
Drug Delivery System ◽  
Delivery System ◽  
Effective Drug ◽  
Ph Responsive ◽  
Spherical Nucleic Acid ◽  
System P ◽  
Spherical Nucleic Acids

This study presents a class of pH-responsive spherical nucleic acids that can exactly image intracellular lysosomes and be an effective drug delivery system.

How are nucleic acids released in cells from cationic lipid-nucleic acid complexes?

1997 ◽  
Vol 24 (2-3) ◽  
pp. 291 ◽  
Author(s):  
Francis C. Szoka ◽  
Yuhong Xu ◽  
Olivier Zelphati
Keyword(s):  
Nucleic Acid ◽  
Nucleic Acids ◽  
Cationic Lipid ◽  
In Cells

scholarly journals Design and enhanced gene silencing activity of spherical 2′-fluoroarabinose nucleic acids (FANA-SNAs)

2021 ◽  
Author(s):  
Hassan H. Fakih ◽  
Adam Katolik ◽  
Elise Malek-Adamian ◽  
Johans J. Fakhoury ◽  
Sepideh Kaviani ◽  
...  
Keyword(s):  
Nucleic Acid ◽  
Nucleic Acids ◽  
Gene Silencing ◽  
Nucleic Acid Therapeutics ◽  
Highly Efficient ◽  
Efficient Delivery ◽  
Spherical Nucleic Acids

Optimizing FANA modified spherical nucleic acids (FANA-SNAs) for highly efficient delivery of nucleic acid therapeutics.

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