A Supramolecular Host for Phosphatidylglycerol (PG) Lipids with Antibacterial Activity

2022 ◽  
Author(s):  
Elliot S Williams ◽  
Hassan Gneid ◽  
Sarah Ruth Marshall ◽  
Mario J González ◽  
Jorgi A Mandelbaum ◽  
...  
Keyword(s):  
Signal Transduction ◽  
Antibacterial Activity ◽  
Energy Storage ◽  
Physiological Functions ◽  
Hydrophobic Barrier

Lipids fulfill a variety of important physiological functions, such as energy storage, providing a hydrophobic barrier, and signal transduction. Despite this plethora of biological roles, lipids are rarely considered a...

The emerging role of PtdIns5P: another signalling phosphoinositide takes its place

2012 ◽  
Vol 40 (1) ◽  
pp. 257-261 ◽  
Author(s):  
Deborah L. Grainger ◽  
Christodoulos Tavelis ◽  
Alexander J. Ryan ◽  
Katherine A. Hinchliffe
Keyword(s):  
Gene Expression ◽  
Signal Transduction ◽  
Membrane Trafficking ◽  
Binding Proteins ◽  
Regulation Of Gene Expression ◽  
Physiological Functions

Of the seven phosphoinositides, PtdIns5P remains the most enigmatic. However, recent research has begun to elucidate its physiological functions. It is now clear that PtdIns5P is found in several distinct subcellular locations, and the identification of a number of PtdIns5P-binding proteins points to its involvement in a variety of key processes, including signal transduction, membrane trafficking and regulation of gene expression. Although the mechanisms that control its turnover are not yet fully understood, the existence of multiple pathways for PtdIns5P regulation is consistent with this emerging versatility.

Ultrastructural aspects of olfactory signal transduction and its development

1994 ◽  
Vol 52 ◽  
pp. 142-143
Author(s):  
Bert Ph. M. Menco
Keyword(s):  
Signal Transduction ◽  
Olfactory Receptor ◽  
Receptor Cell ◽  
Freeze Substitution ◽  
Luminal Surface ◽  
Tissue Sections ◽  
Olfactory Receptor Cells ◽  
Receptor Cells ◽  
Olfactory Signal ◽  
Odor Molecule

Vertebrate olfactory receptor cells are specialized neurons that have numerous long tapering cilia. The distal parts of these cilia line the interface between the external odorous environment and the luminal surface of the olfactory epithelium. The length and number of these cilia results in a large surface area that presumably increases the chance that an odor molecule will meet a receptor cell. Advanced methods of cryoprepration and immuno-gold labeling were particularly useful to preserve the delicate ultrastructural and immunocytochemical features of olfactory cilia required for localization of molecules involved in olfactory signal-transduction. We subjected olfactory tissues to freeze-substitution in acetone (unfixed tissues) or methanol (fixed tissues) followed by low temperature embedding in Lowicryl K11M for that purpose. Tissue sections were immunoreacted with several antibodies against proteins that are presumably important in olfactory signal-transduction.

Progress and perspectives on halide lithium conductors for all-solid-state lithium batteries

2020 ◽  
Vol 13 (5) ◽  
pp. 1429-1461 ◽  
Author(s):  
Xiaona Li ◽  
Jianwen Liang ◽  
Xiaofei Yang ◽  
Keegan R. Adair ◽  
Changhong Wang ◽  
...  
Keyword(s):  
Energy Storage ◽  
Solid State ◽  
Lithium Batteries ◽  
Electrochemical Stability ◽  
Superionic Conductors ◽  
Fundamental Understanding ◽  
Potential Applications ◽  
Synthesis Routes

This review focuses on fundamental understanding, various synthesis routes, chemical/electrochemical stability of halide-based lithium superionic conductors, and their potential applications in energy storage as well as related challenges.

An aqueous hybrid electrolyte for low-temperature zinc-based energy storage devices

2020 ◽  
Vol 13 (10) ◽  
pp. 3527-3535 ◽  
Author(s):  
Nana Chang ◽  
Tianyu Li ◽  
Rui Li ◽  
Shengnan Wang ◽  
Yanbin Yin ◽  
...  
Keyword(s):  
Energy Storage ◽  
Low Temperature ◽  
Energy Storage Devices ◽  
Storage Devices

A frigostable aqueous hybrid electrolyte enabled by the solvation interaction of Zn2+–EG is proposed for low-temperature zinc-based energy storage devices.

Ultrahigh Energy Storage Performances of Polymer-based Nanocomposite via Interfaces Engneering

2020 ◽  
Author(s):  
Peng Wang ◽  
Zhongbin Pan ◽  
Weilin Wang ◽  
Jianxu Hu ◽  
Jinjun Liu ◽  
...  
Keyword(s):  
Dielectric Constant ◽  
Energy Storage ◽  
High Performance ◽  
Breakdown Strength ◽  
Composite Films ◽  
Power Electronic ◽  
Ultrahigh Energy

High-performance electrostatic capacitors are in urgent demand owing to the rapidly development of advanced power electronic applications. However, polymer-based composite films with both high breakdown strength (Eb) and dielectric constant...

Signal-regulated oxidation of proteins via MICAL

2020 ◽  
Vol 48 (2) ◽  
pp. 613-620
Author(s):  
Clara Ortegón Salas ◽  
Katharina Schneider ◽  
Christopher Horst Lillig ◽  
Manuela Gellert
Keyword(s):  
Signal Transduction ◽  
Hydrogen Peroxide ◽  
Cell Death ◽  
Redox Regulation ◽  
Signal Transduction Pathways ◽  
Cellular Functions ◽  
Intracellular Signals ◽  
Amino Acid Side Chains ◽  
Specific Receptors ◽  
Sulfur Containing

Processing of and responding to various signals is an essential cellular function that influences survival, homeostasis, development, and cell death. Extra- or intracellular signals are perceived via specific receptors and transduced in a particular signalling pathway that results in a precise response. Reversible post-translational redox modifications of cysteinyl and methionyl residues have been characterised in countless signal transduction pathways. Due to the low reactivity of most sulfur-containing amino acid side chains with hydrogen peroxide, for instance, and also to ensure specificity, redox signalling requires catalysis, just like phosphorylation signalling requires kinases and phosphatases. While reducing enzymes of both cysteinyl- and methionyl-derivates have been characterised in great detail before, the discovery and characterisation of MICAL proteins evinced the first examples of specific oxidases in signal transduction. This article provides an overview of the functions of MICAL proteins in the redox regulation of cellular functions.

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