scholarly journals Conjugation of a smart polymer to doxorubicin through a pH-responsive bond for targeted drug delivery and improving drug loading on graphene oxide

RSC Advances ◽  
2021 ◽  
Vol 11 (31) ◽  
pp. 18809-18817
Author(s):  
Ali Bina ◽  
Heidar Raissi ◽  
Hassan Hashemzadeh ◽  
Farzaneh Farzad
Keyword(s):  
Drug Delivery ◽  
Graphene Oxide ◽  
Anticancer Drug ◽  
Targeted Drug Delivery ◽  
Polymeric Nanoparticles ◽  
Drug Loading ◽  
Ph Responsive ◽  
Smart Polymer ◽  
Anticancer Drug Delivery ◽  
Targeted Drug

Polymeric nanoparticles have emerged as efficient carriers for anticancer drug delivery because they can improve the solubility of hydrophobic drugs and also can increase the bio-distribution of drugs throughout the bloodstream.

cRGDyK-modified camretastain A4-loaded graphene oxide nanosheets for targeted anticancer drug delivery

RSC Advances ◽  
2015 ◽  
Vol 5 (50) ◽  
pp. 40258-40268 ◽  
Author(s):  
Jing Wang ◽  
Qingqing Tian ◽  
Fang Ding ◽  
Yanyan Yu ◽  
Fanhong Wu
Keyword(s):  
Drug Delivery ◽  
Graphene Oxide ◽  
Anticancer Drug ◽  
Targeted Drug Delivery ◽  
Integrin Expression ◽  
Functionalized Graphene ◽  
Graphene Oxide Nanosheets ◽  
Functionalized Graphene Oxide ◽  
Anticancer Drug Delivery ◽  
Targeted Drug

Functionalized graphene oxide (CGO–cRGDyK/POLO) nanosheets were designed and developed for targeted drug delivery to integrin expression.

Multifunctional sharp pH-responsive nanoparticles for targeted drug delivery and effective breast cancer therapy

2019 ◽  
Vol 7 (4) ◽  
pp. 576-585 ◽  
Author(s):  
Yandan Yao ◽  
Phei Er Saw ◽  
Yan Nie ◽  
Ping-Pui Wong ◽  
Linjia Jiang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Drug Delivery ◽  
Cancer Therapy ◽  
Anticancer Drug ◽  
Targeted Drug Delivery ◽  
Ph Responsive ◽  
Breast Cancer Therapy ◽  
Anticancer Drug Delivery ◽  
Targeted Drug

A new multifunctional pH-responsive NP platform was developed for targeted anticancer drug delivery and effective breast cancer therapy.

Biocompatible magnetic tris(2-aminoethyl)amine functionalized nanocrystalline cellulose as a novel nanocarrier for anticancer drug delivery of methotrexate

2017 ◽  
Vol 41 (5) ◽  
pp. 2160-2168 ◽  
Author(s):  
Mahdi Rahimi ◽  
Salman Shojaei ◽  
Kazem D. Safa ◽  
Zarrin Ghasemi ◽  
Roya Salehi ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Anticancer Drug ◽  
Delivery System ◽  
Targeted Drug Delivery ◽  
Ph Responsive ◽  
Anticancer Drug Delivery ◽  
Amine Functionalized ◽  
Targeted Drug ◽  
Targeted Drug Delivery System

A smart, pH-responsive and biocompatible nanocarrier, aimed to achieve an efficient targeted drug delivery system, was facilely synthesized.

Synthesis of polymeric micelles with dual-functional sheddable PEG stealth for enhanced tumor-targeted drug delivery

2020 ◽  
Vol 11 (27) ◽  
pp. 4469-4476 ◽  
Author(s):  
Lu Sun ◽  
Hua Wei ◽  
Xianshuo Zhang ◽  
Chao Meng ◽  
Guiying Kang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Anticancer Drug ◽  
Targeted Drug Delivery ◽  
Polymeric Micelles ◽  
Anticancer Drug Delivery ◽  
Dual Functional ◽  
Targeted Drug

We reported the synthesis of polymeric micelles with a dual-functional sheddable mPEG stealth to realize simultaneously tumor-triggered targeting and intracellular micelle destabilization for enhanced anticancer drug delivery.

scholarly journals Hydrolysable core crosslinked particles for receptor-mediated pH-sensitive anticancer drug delivery

2015 ◽  
Vol 39 (11) ◽  
pp. 8840-8847 ◽  
Author(s):  
Xifeng Liu ◽  
A. Lee Miller II ◽  
Brian E. Waletzki ◽  
Tewodros K. Mamo ◽  
Michael J. Yaszemski ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Anticancer Drug ◽  
Targeted Drug Delivery ◽  
Ph Sensitive ◽  
Anticancer Drug Delivery ◽  
Targeted Drug

An extracellular stable micelle with a folate conjugated surface, a crosslinked core and pH-sensitive hydrolysable bonds was developed for cancer targeted drug delivery.

TEMPERATURE AND PH RESPONSIVE POLYMERIC NANOPARTICLES FOR TARGETED OXALIPLATIN DELIVERY

INDIAN DRUGS ◽  
2018 ◽  
Vol 55 (11) ◽  
pp. 74-77
Author(s):  
A. S Patil ◽  
◽  
A. P. Gadad
Keyword(s):  
Drug Delivery ◽  
Side Effects ◽  
Targeted Drug Delivery ◽  
Polymeric Nanoparticles ◽  
Ph Responsive ◽  
In Vitro Drug Release ◽  
Dual Responsive ◽  
Targeted Drug ◽  
Targeted Drug Delivery System

In the present study temperature and pH responsive co-polymer chitosan-g-poly(N-isopropylacrylamide) (CS-g-PNIPAAm) was synthesized, characterized and efficiently loaded with oxaliplatin. Nanoparticles were evaluated for their physicochemical properties. The drug loaded nanoparticles showed smooth and spherical morphology with loading efficiency and drug content of about 80.7% and 48.7%, respectively. The in vitro drug release was significantly higher at tumor extracellular pH and temperature when compared to physiological pH and temperature. In conclusion, the developed nanoparticulate system is an effective dual responsive targeted drug delivery system for oxaliplatin with low toxic side effects.

scholarly journals pH-responsive polymeric nanoparticles with tunable sizes for targeted drug delivery

RSC Advances ◽  
2020 ◽  
Vol 10 (9) ◽  
pp. 4860-4868 ◽  
Author(s):  
Mengle Kong ◽  
Xinwen Peng ◽  
Hao Cui ◽  
Peiwen Liu ◽  
Bo Pang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Targeted Drug Delivery ◽  
Polymeric Nanoparticles ◽  
Ph Responsive ◽  
Tumor Microenvironments ◽  
Dialdehyde Cellulose ◽  
Targeted Drug

Novel nanoparticles for efficient drug delivery were designed and constructed using polymeric 2,3-dialdehyde cellulose (DAC). The drug DOX was encapsulated into nanoparticles and underwent thoroughly controlled release in acidic tumor microenvironments.

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